What is NAD?

Learn how NAD+ can extend your healthspan.

Latest Research: Two FDA-Approved Drugs Additively Extend Lifespan

Seragon’s Aging Intervention Drug SRN-901 Achieves One of the Largest Extensions of Lifespan and Healthspan to Date

NAD+ Precursor NR Improves Heart Health in People with Accelerated Aging, New Study Shows

Latest Human Trial from the Buck Institute Shows Plasma Exchange Lowers Biological Age

Do Humans Age More Like Lab or Wild Mice?

Longevity Secrets in Your Genome: Hidden mTOR Variants Identified

New Study Suggests NR Modestly Improves Cognition in Age-Related Vascular Disease

NMN & NR

Nicotinamide mononucleotide (NMN) increases blood levels of nicotinamide adenine dinucleotide (NAD+) to alleviate age-related disorders like metabolic disease and cardiovascular dysfunction.

Clinical Trials

New Study Shows NMN Substantially Increases NAD+ and Enhances Physical Performance

NMN increases blood NAD+, enhances walking distance over a six-minute period, and improves a self-assessed evaluation of health, especially at higher doses in healthy adults.

Harvard Study: NMN Cuts Weight, Cholesterol, and Blood Pressure in Overweight Adults

NMN supplementation significantly reduces body weight, cholesterol, and blood pressure when blood fills the heart (diastolic blood pressure) in overweight or obese adults.

Latest UPenn Study Reveals NMN and NR Have Similar Efficacy in a Kidney Disease Model

Supplementing with nicotinamide mononucleotide (NMN) or nicotinamide riboside (NR) confers comparable benefits against kidney disease in male mice.

This NAD+ precursor shields the heart from injury caused by a chemotherapeutic in rats, preventing the disruption of tissue organization and blood pumping abilities.

This NAD+ precursor shields the heart from injury caused by a chemotherapeutic in rats, preventing the disruption of tissue organization and blood pumping abilities.

Most Popular

Aging & Longevity

94-Year-Old Clint Eastwood’s Longevity Secrets

A series of realizations and personal experiences — like his father’s death from cardiovascular disease — have propelled Clint Eastwood to take care of his health for graceful aging.

Aging & Longevity

David Sinclair’s 2024 Anti-Aging Supplement Protocol

Longevity expert Dr. David Sinclair's 2024 anti-aging protocol includes NMN, fish oil, lipoic acid, resveratrol, metformin, spermidine, and more.

Clinical trials show that urolithin A enhances muscle strength and reduces inflammation.

Clinical trials show that urolithin A enhances muscle strength and reduces inflammation.

Brain & Neurons

Methylene blue — the first man-made medicine — may slow brain aging and improve cognition by targeting our mitochondria.

Methylene blue — the first man-made medicine — may slow brain aging and improve cognition by targeting our mitochondria.

The potential pitfalls of boosting NAD+ levels with NR, NMN, niacin, and nicotinamide are discussed.

The potential pitfalls of boosting NAD+ levels with NR, NMN, niacin, and nicotinamide are discussed.

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Latest News

Aging & Longevity

Ranked fourth on the Rejuvenation Olympics leaderboard, 30-year-old Siim Land lists the supplements he takes to stay young.

Ranked fourth on the Rejuvenation Olympics leaderboard, 30-year-old Siim Land lists the supplements he takes to stay young.

Brain & Neurons

New Study Finds Midlife May Be a Critical Window to Prevent Brain Aging

A new study suggests that supplementing with ketones—molecules the body can use for energy when lacking sugars—prevents cognitive aging when administered in people’s 40s and 50s.

Diabetes & Obesity

Scientists find that NR (nicotinamide riboside) supplementation preserves brown fat tissue in mice, reducing their body weight and maintaining the health of their mitochondria.

Scientists find that NR (nicotinamide riboside) supplementation preserves brown fat tissue in mice, reducing their body weight and maintaining the health of their mitochondria.

NAD+ Supercharges Immune System Recovery in Older Mice

Researchers from the University of California, Berkeley, found that young mice need NAD+ breakdown, while old mice need NAD+ boosting.

Aging & Longevity

Drug Approved Against Tapeworms May Counteract Aging, Suggests New Study

New research suggests niclosamide, approved for human use against tapeworms, alleviates frailty and suppresses the protein complex mTOR, which regulates cell growth, in aged mice.

Brain & Neurons

The NAD+-consuming enzyme CD38 is elevated in individuals predisposed to Alzheimer’s, and blocking it improves the metabolic health and cognition of mice that model Alzheimer’s.

The NAD+-consuming enzyme CD38 is elevated in individuals predisposed to Alzheimer’s, and blocking it improves the metabolic health and cognition of mice that model Alzheimer’s.

Pioneering expert in NAD+ metabolism, Shin-Ichiro Imai, MD, PhD, explains the critical role of NAD+ in preventing chronic kidney disease, the ninth leading cause of death worldwide.

Pioneering expert in NAD+ metabolism, Shin-Ichiro Imai, MD, PhD, explains the critical role of NAD+ in preventing chronic kidney disease, the ninth leading cause of death worldwide.

Aging & Longevity

After accounting for previously unaddressed issues, researchers find that human lifespan is over 50% heritable, challenging previous estimates of 25%.

After accounting for previously unaddressed issues, researchers find that human lifespan is over 50% heritable, challenging previous estimates of 25%.

Aging & Longevity

Seragon’s RESTORIN and the Evolution of Aging Interventions Containing NAD+ Precursors

Aging interventions that include NAD+ precursors have evolved, adding components targeting various hallmarks of aging, from inflammation to cell waste elimination.

Removing an NAD+ transporter called SLC25A51 from insulin-secreting cells mitigates diabetes and reduces senescent cells — cells that contribute to the pathology of age-related diseases.

Removing an NAD+ transporter called SLC25A51 from insulin-secreting cells mitigates diabetes and reduces senescent cells — cells that contribute to the pathology of age-related diseases.

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