What is NAD?

Learn how NAD+ can extend your healthspan.

Beyond Aligning Life with Light: Supplements that Counter Circadian Decline

Seragon’s Aging Intervention Drug SRN-901 Achieves One of the Largest Extensions of Lifespan and Healthspan to Date

Innovative Computer Model Reveals Aging May Stem from Lost Cellular Purpose

Boosting NAD+ May Defy Aging by Enhancing Energy Flow, According to a New Theory

New Research: Magnesium, L-Theanine, NAD+ Combo Counters Stress Aging

The Latest Insight on Anti-Aging Therapeutics Targeting Cardiovascular Disease

How American Country Music Icon Willie Nelson Has Defied Age Limitations into His 90s

NMN & NR

Nicotinamide mononucleotide (NMN) increases blood levels of nicotinamide adenine dinucleotide (NAD+) to alleviate age-related disorders like metabolic disease and cardiovascular dysfunction.

Clinical Trials

New Study Shows NMN Substantially Increases NAD+ and Enhances Physical Performance

NMN increases blood NAD+, enhances walking distance over a six-minute period, and improves a self-assessed evaluation of health, especially at higher doses in healthy adults.

Harvard Study: NMN Cuts Weight, Cholesterol, and Blood Pressure in Overweight Adults

NMN supplementation significantly reduces body weight, cholesterol, and blood pressure when blood fills the heart (diastolic blood pressure) in overweight or obese adults.

Latest UPenn Study Reveals NMN and NR Have Similar Efficacy in a Kidney Disease Model

Supplementing with nicotinamide mononucleotide (NMN) or nicotinamide riboside (NR) confers comparable benefits against kidney disease in male mice.

This NAD+ precursor shields the heart from injury caused by a chemotherapeutic in rats, preventing the disruption of tissue organization and blood pumping abilities.

This NAD+ precursor shields the heart from injury caused by a chemotherapeutic in rats, preventing the disruption of tissue organization and blood pumping abilities.

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Aging & Longevity

Chinese scientists have genetically engineered stem cells capable of rejuvenating the health, including the cognition, of aged macaques.

Chinese scientists have genetically engineered stem cells capable of rejuvenating the health, including the cognition, of aged macaques.

A high but not low dose of nattokinase is associated with reducing artery plaque size by 36% in older adults.

A high but not low dose of nattokinase is associated with reducing artery plaque size by 36% in older adults.

Aging & Longevity

David Sinclair’s 2024 Anti-Aging Supplement Protocol

Longevity expert Dr. David Sinclair's 2024 anti-aging protocol includes NMN, fish oil, lipoic acid, resveratrol, metformin, spermidine, and more.

Aging & Longevity

Want to Get Fit? Look at What Sylvester Stallone Does at 78

Sylvester Stallone’s daily diet includes egg whites as well as broiled chicken and fish for plenty of protein, and his most current workouts focus on the chest, back, abs, and legs for optimal longevity.

Older adults with LDL cholesterol levels above 130 mg/dL live longer than older adults with LDL cholesterol levels below 130 mg/dL.

Older adults with LDL cholesterol levels above 130 mg/dL live longer than older adults with LDL cholesterol levels below 130 mg/dL.

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Latest News

Aging & Longevity

Three Compounds Show Promise for Male Longevity

Data from a rigorous longevity study show promise for three new compounds, adding to the repertoire of mouse lifespan-extending substances.

α-Lipoic Acid: Efficacy, Safety, and Dosage

α-lipoic acid is an antioxidant naturally produced by the body, which is also available as a supplement, and human trials indicate that it has neuroprotective and male fertility-enhancing effects.

Aging & Longevity

Chinese scientists have genetically engineered stem cells capable of rejuvenating the health, including the cognition, of aged macaques.

Chinese scientists have genetically engineered stem cells capable of rejuvenating the health, including the cognition, of aged macaques.

Aging & Longevity

Researchers Identify Key Cellular Changes Around Age 50 That Accelerate Aging

The Chinese Academy of Sciences' findings may explain why aging makes us sicker and suggest new ways to detect and reverse aging.

Human Trial Finds Nitrate-Enhanced Juice Lowers Blood Pressure

A new human trial yields data showing that nitrate-rich beetroot juice alters the oral microbe composition and lowers blood pressure in older participants.

Does NAD+ (nicotinamide adenine dinucleotide) really help with aging? A team of international scientists reviews the latest and ongoing clinical trials.

Does NAD+ (nicotinamide adenine dinucleotide) really help with aging? A team of international scientists reviews the latest and ongoing clinical trials.

Brain & Neurons

Cutting-edge technology has allowed scientists to examine young and old brains with single-cell resolution, gaining insights into how we can rejuvenate our brain cells to stay sharp.

Cutting-edge technology has allowed scientists to examine young and old brains with single-cell resolution, gaining insights into how we can rejuvenate our brain cells to stay sharp.

Brain & Neurons

Study shows that brief nicotinamide + EGCG treatment restores neuronal energy in 16–24 hours, restores autophagy, reduces amyloid-beta buildup, and boosts neuron survival by ~22% in aging/Alzheimer’s lab models.

Study shows that brief nicotinamide + EGCG treatment restores neuronal energy in 16–24 hours, restores autophagy, reduces amyloid-beta buildup, and boosts neuron survival by ~22% in aging/Alzheimer’s lab models.

Three types of beer, including IPA and stout, are shown to improve indicators of metabolic health in a mouse model for aging.

Three types of beer, including IPA and stout, are shown to improve indicators of metabolic health in a mouse model for aging.

Brain & Neurons

Harvard Study: A Low Dose of Lithium May Preserve Cognitive Resilience with Age

Researchers uncover significantly lower brain lithium levels in Alzheimer’s disease patients, and supplementing with a low-dose lithium salt restores memory in an Alzheimer’s disease mouse model.

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