Making CAR-T Cells Young Again: Restoring NAD+ to Rejuvenate Immunotherapy in Aging

A combined treatment of NMN with 78c (a small molecule that inhibits an NAD+-degrading enzyme) enhances the effects of the anti-cancer CAR-T cell therapy in aged mice and human cells.

(A CAR-T cell [red] attacking a cancer cell [blue] | Crown Bioscience Blog)

Cancer

Model: Cybrids composed of Rho0 cells with human platelet mitochondrial DNA from participants between 7 days old and 99 years old 
Dosage: 5 mM of n-Acetyl-L-Cysteine and 3 mM of nicotinamide riboside, with medium changed every three days until the cell population reached between 1 and 10 million

New Study: Combining NR with NAC May Slow Telomere Shortening

New research suggests that nicotinamide riboside (NR) combined with N-acetyl cysteine (NAC) prevents telomere shortening linked to genetic sequences within the cell’s powerhouse (mitochondria) in human cells.

(Telomeres [highlighted in gold] at the ends of a chromosome | NAD.com)

A new study suggests the NAD+ precursor NR combined with the antioxidant NAC may counteract telomere shortening, a hallmark of aging.

Aging &amp; Longevity

Model: 8 adults with peripheral artery disease 
Dosage: 1,000 mg of NR daily for four weeks

New Study Suggests NR Modestly Improves Cognition in Age-Related Vascular Disease

Taking NR was associated with improved blood flow to a specific brain region following cognitive stimulation, as well as trends toward enhanced cognition in patients with age-related vascular disease.

(The study’s principal investigator, Andriy Yabluchanskiy | LinkedIn)

Taking NR is associated with improved blood perfusion to a brain region involved in memory and daily task organization, as well as a trend toward enhanced cognition.

Brain &amp; Neurons

Model: 40 aged patients with COPD with an average age of 71.9 
Dosage: One gram of NR taken twice daily for a total of two grams per day for six weeks

Fresh Insights: NR’s Effects on Inflammation in Age-Related Lung Disease

Taking nicotinamide riboside (NR) is tied to a 52.6% reduction of an inflammatory protein in the sputum—mucus coughed up from the respiratory tract—of patients with chronic obstructive pulmonary disease (COPD).

(Principal investigator Dr. Morten Scheibye-Knudsen, Associate Professor from the University of Copenhagen | Videnskab DK)

NR (nicotinamide riboside) improves the walking performance of individuals with cardiovascular disease, but adding resveratrol does not improve performance further. 



Nicotinamide riboside improves the physical performance of cardiovascular diseases patients. 

NAD+ Precursors, Aging, and Longevity: Dr. Peter Attia’s Thoughts

Dr. Peter Attia shares his thoughts on NAD+ precursors, their potential impact on aging and longevity, and the importance of further research in this field.

Model: C57BL/6J mice and Abca1/g1-m/-m mice of both sexes and bone marrow-derived macrophages from C57BL/6J and Abca1/g1-m/-m mice
Dosage: 300 mg/kg of NMN by daily intraperitoneal injection for two weeks, 5 mg/kg of dasatinib and 50 mg/kg of quercetin by oral gavage for five consecutive days every two weeks for three months, and a 500 μM concentration of NMN for bone marrow-derived macrophages in laboratory dishes

Revitalizing Immune Cells & Eye Function: NMN Study Unveils Remarkable Findings

A new study suggests that NMN reverses an age-associated dysfunctional cellular state — senescence — in immune cells and restores eye function in an age-related eye disease mouse model.

(An anatomical view of an eye with age-related macular degeneration | NAD.com)

NMN reverses an age-related dysfunctional state in immune cells — senescence — and improves eye function in an age-related eye disease mouse model.

Based primarily on discussions with guests on his popular podcast, the supplements Joe Rogan has taken include NMN, resveratrol, vitamin D, fish oil, and more.  



Joe Rogan (Image: Joe Rogan’s X account) 

The supplements that Joe Rogan has taken, according various social media posts and conversations he's had with guest on his podcast. 

65-year-old Dr. Drew Pinsky, who has been taking NR for about 10 years, said, “If I had access to only one supplement, NR would be that supplement.” 

Dr. Drew says if he could take only one supplment, it would be NR. 

David Sinclair’s 2024 Anti-Aging Supplement Protocol

Longevity expert Dr. David Sinclair's 2024 anti-aging protocol includes NMN, fish oil, lipoic acid, resveratrol, metformin, spermidine, and more.

Making CAR-T Cells Young Again: Restoring NAD+ to Rejuvenate Immunotherapy in Aging

New Study: Combining NR with NAC May Slow Telomere Shortening

New Study Suggests NR Modestly Improves Cognition in Human Subjects

Fresh Insights: NR’s Effects on Inflammation in Age-Related Lung Disease

NAD+ Precursor NR Improves Physical Performance but not Resveratrol: New Clinical Study

NAD+ Precursors, Aging, and Longevity: Dr. Peter Attia’s Thoughts

Revitalizing Immune Cells & Eye Function: NMN Study Unveils Remarkable Findings

Podcaster Joe Rogan’s Top 2024 Supplements Beyond NAD+ Precursor NMN

Dr. Drew Says NR is the Best NAD+ Precursor

David Sinclair’s 2024 Anti-Aging Supplement Protocol