Scientists maintain the function of fat-derived stem cells by boosting NAD+ with nicotinamide riboside (NR), which could combat age-related liver and muscle ailments.



A woman next to a nicotinamide riboside (NR) molecule. 

Model: Male C57BL/6 mice
Dosage: 400 mg/kg/day by oral gavage for 21 days starting at eight weeks after ionizing radiation exposure

NAD+ Precursor NR Counteracts Damaging Anticancer Radiation Therapy: New Study

Researchers show nicotinamide riboside (NR) restores exercise capacity, increases white and red blood cells, and alleviates stem cell senescence in prematurely aged mice exposed to radiation for treating cancer.

(An aged mouse undergoing ionizing radiation cancer therapy | NAD.com)

NR restores physical function, increases blood cell counts, and reduces bone marrow stem cell senescence in mice exposed to ionizing radiation.

Harnessing Hope: NAD Precursor NR Counters Damaging Effects of Anticancer Radiation Therapy, Reveals New Study

Model: Adults between 55 and 70 years of age for measuring how different NMN dosages affect blood NAD+ concentrations
Dosage: 500 mg or 1,000 mg per day of oral NMN for 30 days

New NAD+ Blood Test Kit Available

Researchers unveil an easy-to-use and cost-effective blood nicotinamide adenine dinucleotide (NAD+) concentration reading device that they apply to confirm falling NAD+ in aged humans and NMN's restorative effects on NAD+ levels.

(Pricking one’s finger to collect a blood sample for an NAD+ concentration reading)

Discover the groundbreaking finger-prick blood test that confirms the decline of NAD+ levels in aging humans. Explore the latest insights and findings at NAD.com to understand the science behind aging and NAD+ decline.

New NAD⁺ Blood Test Kit Available

NAD+ Precursors: Unlocking the Fountain of Youth by Maximizing NAD+ Levels

Nicotinamide adenine dinucleotide (NAD+) levels decline with age, which has been linked to age-related conditions, yet NAD+-boosting precursors replenish this essential molecule.

Maximizing NAD+ levels with the precursors tryptophan, nicotinic acid, nicotinamide, NMN, or NR can alleviate age-associated diseases like cardiovascular ailments and neurodegenerative conditions.

Aging &amp; Longevity

Model: Human chronic kidney disease patients with an average age of 60
Dosage: 1,000 mg per day of NR by pill for six weeks; 1,200 mg per day of CoQ10 by pill for six weeks

NR and CoQ10 Improve Kidney Function: Latest Study

A kidney disease patient study reveals nicotinamide riboside (NR) increases intermediate molecules of metabolism, and NR and coenzyme Q10 (CoQ10) both reduce harmful fats.

(University of California, Davis | theaggie.org)

NR significantly increases mitochondrial metabolism molecular intermediates, while both NR and CoQ10 improve lipid metabolism profiles, both suggesting metabolic improvements.

Clinical Trials

Model: hESC-derived neurons
Dosage: Nicotinamide (NAM) (Sigma-Aldrich), 1 mM Nicotinamide riboside (NR) (ChromaDex), 1 mM Nicotinamide mononucleotide (NMN) (NMN Bio)

 Latest MIT Study Shows NMN and NR Are Potential Targets for Neurodegenerative Diseases

A new study from MIT and the University of Birmingham in the UK shows that the NAD+ precursors nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) can save neurons with dysfunctional cell recycling (autophagy) that looks like neurodegenerative and lysosomal storage diseases.


Model: Arthritis patient whole blood and peripheral blood mononuclear cells
Dosage: 1 mM NR, nicotinamide, or NMN

NAD+ Deficiency in Arthritis Patients Reversed by NMN and NR: Latest Study Findings

Spanish researchers characterize NAD+ boosting compounds’ efficacy against falling NAD+ in rheumatoid arthritis patients’ immune cells, with nicotinamide riboside (NR) and nicotinamide producing promising effects.

(The study’s principal investigator, José Manuel Villalba | ABC)

Whole blood NAD+ levels predict disease severity in rheumatoid arthritis patients, and NR or nicotinamide supplementation increases NAD+ levels in arthritis patient immune cells.

Model: Mouse
Dosage: Nicotinamide Riboside (400 mg/kg/day)

Study Reveals NR Slows Liver Cancer Progression in Mice

Nicotinamide riboside (NR) could slow the spread of cancer in mice with tumors and help them keep their weight up in the late stages of the disease.


Model: C57BL/6J 8-week male mice
Dosage: 400 mg/kg of NR by oral gavage daily for 10 days

Study Shows that NR Helps Prevent Alcohol-Induced Gut Injury

Mice given nicotinamide riboside (NR) – an NAD+ precursor – were prevented from getting alcohol-induced intestinal injury, despite excessive alcohol consumption, with beneficial effects on mitochondrial function (the cell’s main energy producer) and possible implications for inflammation and age-related intestinal injuries. 


Model: C57BL/6J male mice
Dosage: 500 mg/kg/day of NMN and 435 mg/kg/day of NR intraperitoneally injected for four consecutive days beginning two hours before cisplatin-induced kidney injury

Latest UPenn Study Reveals NMN and NR Have Similar Efficacy in a Kidney Disease Model

Supplementing with nicotinamide mononucleotide (NMN) or nicotinamide riboside (NR) confers comparable benefits against kidney disease in male mice.

(The study’s principal investigator, Dr. Katalin Susztak, MD, PhD | Emory Daily Pulse)

NMN and NR have similar effects in reducing molecular markers for kidney dysfunction in a mouse model for kidney disease.

When More Fat is Good: Study Shows NAD⁺ Precursor NR Rejuvenates Fat Stem Cells

NAD⁺ Precursor NR Counteracts Damaging Anticancer Radiation Therapy: New Study