Niacin (vitamin B3) triggers immune cells to attack human brain tumor initiating cells.

brain-tumor

Brain Tumor

Niacin, also called vitamin B3, stimulates immune cells to attack cells that initiate human brain tumors.

Combating Brain Cancer Using Common Vitamins

Model: NOD/SCID mice
Dosage: 3.4 mg/kg/day of neopetroside-B injected for three consecutive days

NAD+ Boosting Neopetroside-B Protects the Heart and Suppresses Cancer

Researchers show treatment with the nicotinamide adenine dinucleotide (NAD+) precursor neopetroside-B increases heart cell survival, prevents chemotherapy-induced heart scarring, and reduces tumor volume in mice.

neopetroside-b-1

Neopetroside B (1)

(The molecular structure of the NAD+ precursor neopetroside-B)

Discover groundbreaking findings from a Korean study on Neopetroside-B's remarkable role in safeguarding the heart during chemotherapy while also exhibiting cancer-suppressing properties. Learn how NAD augmentation holds promise for enhanced cancer treatments.

NAD Boosting Neopetroside-B: Protecting the Heart during Chemotherapy & Suppressing Cancer – Korean Study

Cancer

Vitamin D reduces human colorectal cancer cell growth by activating the NAD+ dependent enzyme sirtuin-1. 

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University of Rey Juan Carlos in Spain (photo: Eduardo Parra / Europa Press). 

Explore groundbreaking research from Spain revealing how Vitamin D activates NAD-dependent molecules to combat cancer. Discover the implications of this study and its potential in cancer treatment at NAD.com.

Vitamin D Activates NAD-Dependent Molecule to Combat Cancer: Research from Spain | NAD

Model: Human neuroblastoma (SK-N-BE(2)c), breast cancer (MDA-MB-468), and small-cell lung cancer (H82) cells; ES1e/SCID mice
Dosage: 500 nM of AOH1996 for 18 hours of cell treatment; 40 mg/kg of AOH1996 twice daily administered orally for mice

City of Hope Study Shows New Drug Kills Multiple Solid Tumors

Researchers demonstrate that an investigational small molecule selectively disrupts DNA repair and replication in cancer cells to suppress tumor growth in mice.

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MALKAS (1)

(The study’s principal investigator, Linda H. Malkas, PhD | Radiome.gr)

Discover the groundbreaking findings of the latest cancer study, unveiling a new chemotherapeutic agent's efficacy in targeting and killing various solid tumors. Explore the promising implications of this research at NAD.com.

Latest Cancer Study Reveals Breakthrough: New Chemotherapeutic Agent Targets Multiple Solid Tumors | NAD

Model: Male Wistar rats
Dosage: 1&#215;109 CFU of probiotics daily and 15 to 30 mg/kg of pterostilbene daily

Promising New Study: Probiotics Significantly Reduce Colon Cancer Risk

Probiotics reduce precancerous lesions and cancer-associated cellular proteins in the colon of carcinogen-exposed rats.

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CEARA (1)

(Federal University of Ceará | grancursosonline.com.br)

Supplementing with probiotics decreases the prevalence of tube-like glands called aberrant crypt foci in the colon that give rise to colorectal cancer, and adding pterostilbene increases antioxidant activity.

Model: Female BALB/c mouse model for colon cancer (C26-F)
Dosage (oral): 150 mg/kg/day of niacin

The NAD+ precursor niacin counters muscle mass and strength loss in a mouse model for colon cancer. 

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Corresponding scientist Dr. Eija Pirinen | University of Oulu 

Model: 18-month-old CD45.2 mice
Dosage: 4 ug Netrin-1 via injection; 5 injections total; once every 35 days

Researchers Rejuvenate Aged Mouse Blood Stem Cells

Infusing blood with a molecule critical for development, Netrin-1, improves the bone marrow niche in older people and restores the function of older blood stem cells, which has the potential to help people live longer.


Basic Research

Model: Terminally-ill humans with treatment-resistant cancer
Dosage: 20, 40, or 60 mg/m2 of ATX-101 injected weekly via infusion for six weeks

Breakthrough New Drug Can Stop Multiple Cancer Types: Australian Study

High percentages of terminally ill and treatment-resistant cancer patients show stopped tumor growth following ATX-101 treatment.

otterlei-2

Otterlei

(One of ATX-101’s key developers, Marit Otterlei)

A new drug stops tumor growth in 70% of patients with treatment-resistant cancer types that render them terminally ill by targeting a protein that helps cancer cells survive stress.

Model: C57BL/6N or BALB/c mice 
Dosage: 2 mg/kg of spermidine by intraperitoneal injection

Kyoto University researchers find spermidine inhibits tumor growth in mice by improving the mitochondrial function of anticancer immune cells.

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(The study’s principal investigator, Dr. Tasuku Honjo | Japan Times)

Nicotinamide Riboside (NR) – an NAD+ precursor – which has been shown to positively affect age-related changes, was found to affect secondary cancer growth (metastases) using a newly developed biosensor.


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Elena Goun

Senior Author, Dr. Elena Goun | E. Budnikova, Nature Methods 

NAD+ Boosting Agent Suppresses Brain Tumor Growth

Mitchell Cancer Institute (MCI) researchers find that elevated NAD+ levels help prevent the growth of chemotherapy-resistant brain tumor cells. 

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Sobol-research_200217_144010_1

Senior author, Dr. Robert W. Sobol | University of Southern Alabama Health 

100% of Rectal Cancer Patients Cured by Immunotherapy

Twelve patients obtained remission for advanced rectal cancer with 6 months of immunotherapy, featuring dostarlimab (PD-1 antibody), in a Sloan Kettering and Yale collaborative Phase 2 clinical study.

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Investigators Dr. Luis Diaz and Dr. Andrea Cercek (lab coats) and four successfully treated patients | Memorial Sloan Kettering Cancer Center

Ptf1a-CreER (C57Bl6), Pdx1-Cre (C57Bl6), LSL-Kras+/G12D Mice
ABT-737: 25 mg/kg
Sulindac: 0.6 mg/ml

New Study Shows Senolytics Can Halt Cancer Development 

Israeli researchers show that the senolytic drug ABT-737 halts the development of precancerous lesions in the pancreas by eliminating senescent cells - cells that are in a permanent state of cell-cycle arrest. 


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Pancreas,Cancer,Anatomy,Diagram,And,Pancreatic,Malignant,Tumor,Concept,As

Model: adults 70 years and older
Dosage (3-year duration): 2000 IU Vitamin D3, 1 gram omega-3s (500 mg DHA and EPA), 
and 30 minutes of strength exercises three times a week.

Vitamin D₃ Plus Omega-3 Linked to 60% Lower Cancer Risk

Swiss scientists find an association between reduced risk for cancer and combined vitamin D, omega-3 fatty acids, and exercise in older adults. 


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Zurich,,Switzerland,-,June,3,,2015:,Entrance,To,The,University

By delivering mRNA in lipid nanoparticles to generate engineered immune cells in mice, researchers show proof of concept for a technology to reduce fibrosis and restore heart function. 


t-cell

Researchers provide proof of concept for a technique to minimize fibrosis and restore cardiac function by delivering mRNA in lipid nanoparticles to produce modified immune cells in mice.

Cardiovascular

Does NAD cause cancer? Research from ​​ShanghaiTech indicates the potential for targeting NAD+ metabolism to treat cancer more effectively.


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3d,Illustration,Of,T,Cells,Attacking,A,Cancer,Cell,(car-t

Boosting NAD+ levels with nicotinamide supplementation in concert with CAR T immunotherapy effectively eliminates tumors in mice.

NAD Boosting Supplement Showcases Benefits for Anti-Tumor Immunotherapy

T lymphocytes that infiltrate and suppress tumors progressively lose their ability to function, but nicotinamide riboside (NR) supplementation enhances T cell mitochondrial fitness to sustain the antitumor response.

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Mitochondria, a membrane-enclosed cellular organelles, which produce energy Mitochondria , Cell energy and Cellular respiration Mitochondrial disease Mitochondrial DNA

Supplementation of NR may enhance fitness of mitochondria to progressively suppress tumors.

Activating Immune Cells with a Common Vitamin to Fight Off Deadly Brain Cancer

NAD⁺ Boosting Molecule Protects the Heart Against Chemotherapy and Suppresses Cancer: Korean Study

Vitamin D Stops Cancer Growth by Activating NAD⁺ and Sirtuin-1: Research from Spain

City of Hope Study Shows New Drug Kills Multiple Solid Tumors

Promising New Study: Probiotics Significantly Reduce Colon Cancer Risk

Restoring NAD⁺ via Niacin Curtails Muscle Loss from Cancer: Italian & Finnish Scientists

Researchers Rejuvenate Aged Mouse Blood Stem Cells

Breakthrough New Drug Can Stop Multiple Cancer Types: Australian Study

Japanese Study Suggests Spermidine Enhances Immunity Against Cancer

New Study Suggests NR May Be Bad for Cancer Patients

MCI Scientists Find NAD⁺ Boosting Agent Suppresses Brain Tumor Growth

100% Rectal Cancer Remission through PD-1 Immunotherapy

The Senolytic ABT-737 Halts Pancreatic Cancer Development in Mice

Swiss Study Shows Vitamin D₃ Plus Omega-3 Linked to 60% Lower Cancer Risk

UPenn Researchers Engineer Immune Cells that Restore Heart Function

Study Shows NAD⁺-Boosting Supplement Enhances Anti-Tumor Immunotherapy

NR Can Enhance T Cell Antitumor Immunity Through Mitochondrial Function Restoration