Niacin (vitamin B3) triggers immune cells to attack human brain tumor initiating cells.

brain-tumor

Brain Tumor

Niacin, also called vitamin B3, stimulates immune cells to attack cells that initiate human brain tumors.

Combating Brain Cancer Using Common Vitamins

Model: C57BL/6N or BALB/c mice 
Dosage: 2 mg/kg of spermidine by intraperitoneal injection

Kyoto University researchers find spermidine inhibits tumor growth in mice by improving the mitochondrial function of anticancer immune cells.

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(The study’s principal investigator, Dr. Tasuku Honjo | Japan Times)

Nicotinamide Riboside (NR) – an NAD+ precursor – which has been shown to positively affect age-related changes, was found to affect secondary cancer growth (metastases) using a newly developed biosensor.


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Elena Goun

Senior Author, Dr. Elena Goun | E. Budnikova, Nature Methods 

NAD+ Boosting Agent Suppresses Brain Tumor Growth

Mitchell Cancer Institute (MCI) researchers find that elevated NAD+ levels help prevent the growth of chemotherapy-resistant brain tumor cells. 

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Sobol-research_200217_144010_1

Senior author, Dr. Robert W. Sobol | University of Southern Alabama Health 

100% of Rectal Cancer Patients Cured by Immunotherapy

Twelve patients obtained remission for advanced rectal cancer with 6 months of immunotherapy, featuring dostarlimab (PD-1 antibody), in a Sloan Kettering and Yale collaborative Phase 2 clinical study.

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Investigators Dr. Luis Diaz and Dr. Andrea Cercek (lab coats) and four successfully treated patients | Memorial Sloan Kettering Cancer Center

Ptf1a-CreER (C57Bl6), Pdx1-Cre (C57Bl6), LSL-Kras+/G12D Mice
ABT-737: 25 mg/kg
Sulindac: 0.6 mg/ml

New Study Shows Senolytics Can Halt Cancer Development 

Israeli researchers show that the senolytic drug ABT-737 halts the development of precancerous lesions in the pancreas by eliminating senescent cells - cells that are in a permanent state of cell-cycle arrest. 


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Pancreas,Cancer,Anatomy,Diagram,And,Pancreatic,Malignant,Tumor,Concept,As

Cancer

Model: adults 70 years and older
Dosage (3-year duration): 2000 IU Vitamin D3, 1 gram omega-3s (500 mg DHA and EPA), 
and 30 minutes of strength exercises three times a week.

Vitamin D₃ Plus Omega-3 Linked to 60% Lower Cancer Risk

Swiss scientists find an association between reduced risk for cancer and combined vitamin D, omega-3 fatty acids, and exercise in older adults. 


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Zurich,,Switzerland,-,June,3,,2015:,Entrance,To,The,University

By delivering mRNA in lipid nanoparticles to generate engineered immune cells in mice, researchers show proof of concept for a technology to reduce fibrosis and restore heart function. 


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Researchers provide proof of concept for a technique to minimize fibrosis and restore cardiac function by delivering mRNA in lipid nanoparticles to produce modified immune cells in mice.

Cardiovascular

Does NAD cause cancer? Research from ​​ShanghaiTech indicates the potential for targeting NAD+ metabolism to treat cancer more effectively.


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3d,Illustration,Of,T,Cells,Attacking,A,Cancer,Cell,(car-t

Boosting NAD+ levels with nicotinamide supplementation in concert with CAR T immunotherapy effectively eliminates tumors in mice.

NAD Boosting Supplement Showcases Benefits for Anti-Tumor Immunotherapy

T lymphocytes that infiltrate and suppress tumors progressively lose their ability to function, but nicotinamide riboside (NR) supplementation enhances T cell mitochondrial fitness to sustain the antitumor response.

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Mitochondria, a membrane-enclosed cellular organelles, which produce energy Mitochondria , Cell energy and Cellular respiration Mitochondrial disease Mitochondrial DNA

Supplementation of NR may enhance fitness of mitochondria to progressively suppress tumors.

Activating Immune Cells with a Common Vitamin to Fight Off Deadly Brain Cancer

Japanese Study Suggests Spermidine Enhances Immunity Against Cancer

New Study Suggests NR May Be Bad for Cancer Patients

MCI Scientists Find NAD+ Boosting Agent Suppresses Brain Tumor Growth

100% Rectal Cancer Remission through PD-1 Immunotherapy

The Senolytic ABT-737 Halts Pancreatic Cancer Development in Mice

Swiss Study Shows Vitamin D₃ Plus Omega-3 Linked to 60% Lower Cancer Risk

UPenn Researchers Engineer Immune Cells that Restore Heart Function

Study Shows NAD+-Boosting Supplement Enhances Anti-Tumor Immunotherapy

NR Can Enhance T Cell Antitumor Immunity Through Mitochondrial Function Restoration