What is NAD?

A naturally occurring compound, α-lipoic acid, helped elderly mice think like younger mice by restoring energy balance and calming brain inflammation, according to Second Hospital of Hebei Medical University researchers.

In older adults, the combination of nicotinamide, palmitoylethanolamide (PEA), oleoylethanolamide (OEA), and spermidine counters cardiovascular and metabolic aging.

Stanford neuroscientist Andrew Huberman’s updated supplement list includes the NAD+ precursor NMN, along with other compounds for sleep and cognitive performance.

Harvard researchers find that aged mice lacking gut bacteria exhibit a brain more like that of young mice.

In mice, cordycepin—a molecule found in cordyceps mushrooms—prolongs lifespan and improves memory, strength, cardiac function, hormone levels, and metabolism.

A new aging model posits that aging imprints signatures across molecular, tissue, and organ system levels, and these signatures may also transmit across generations.

Ginseng supplementation boosts NAD+ (nicotinamide adenine dinucleotide) and lengthens telomeres in middle-aged adults, suggesting an amelioration of aging.

Buck Institute scientists find that blocking the CD38 enzyme, which elevates NAD+ (nicotinamide adenine dinucleotide), counteracts age-related cognitive and physical decline in mice.

Delivering a gene therapy targeting ensembles of neurons that store memories restores learning and memory capabilities in mouse models of aging and Alzheimer’s disease.

NR (nicotinamide riboside) raises blood NAD+ (nicotinamide adenine dinucleotide) levels more than NMN (nicotinamide mononucleotide) in healthy adults.