Senolytics Restore Bone Healing Capacity in Older Age

Study Identifies New Age-Reversing Drug Cocktail 

Turmeric Metabolite Improves Age-Related Memory Deficits

New Study Shows Senolytics Can Halt Cancer Development 

Vitamin D₃ Plus Omega-3 Linked to 60% Lower Cancer Risk

UPenn Researchers Engineer Immune Cells that Restore Heart Function

Washington University Study: NMN Restores NAD+ in an Age-Modulating Brain Region

NAD+- and Metabolism-Boosting Formula Aids Neurodegenerative Diseases: British Study

NAD+ Booster Lowers Neurodegenerative Markers 

University of Arizona Study Shows Moderate Calorie-Restricted Diet Improves Metabolism and Physical Function

Immucillin H Enhances NR's NAD+ Boosting Effect

Ketogenic Diet Restores Alzheimer’s Memory Deficits and Neurodegeneration

Senolytics Promote Cardiac Regeneration in Heart Attack Model 

Cardiac Dysfunction in Diabetes Reduced by NAD+ Booster 

Functional Human Heart Tissue Recreated from Animal Scaffolding

 NAD+ Nanoparticles Increase Survival from Sepsis by Over Fourfold 

Researchers Find Blocking Gut Metabolite   Prevents Cognitive Decline

Study from Sweden Suggests Nerve Stimulation Device Could Slow Aging

Researchers discuss data challenging the proposal that NR supplementation improves the function of the cell’s powerhouse, the mitochondria, in humans.

capsule

Moore and Mucinski provide commentary on the Dollerup et al. (2020) study that did not support NR boosting NAD+ levels or improving mitochondrial function in human skeletal muscle.

A New Perspective on NR Supplementation

In the second podcast based on his book LifeSpan, Dr. Sinclair talks about the science behind how fasting and eating certain foods promote longevity.

NAD+ IV therapy is a method for receiving the potential therapeutic benefits of NAD+, but there is little to no clinical evidence demonstrating its effects on aging. 

NAD Drip Therapy | How Does it Work | Why is it Popular?

Supplementing with the NAD+ precursor NR (nicotinamide riboside) enhances exercise performance and reduces oxidative stress in older but not younger men. 


According to a study, increasing NAD+ levels with NR decreases oxidative stress and improves exercise performance in older men, but not in younger men.

Model: Female C57BL/6 mice
Dosage: Fasting every-other-day

Scientists find that intermittent fasting – fasting every other day – increases mouse litter size and raises NAD+ in aged mouse eggs (oocytes).

From left to right: young, aged, and aged + intermittent fasting mouse egg cells stained with a green marker for cell death.

Model: C57BL/6J 8-week male mice
Dosage: 400 mg/kg of NR by oral gavage daily for 10 days

Study Shows that NR Helps Prevent Alcohol-Induced Gut Injury

Mice given nicotinamide riboside (NR) – an NAD+ precursor – were prevented from getting alcohol-induced intestinal injury, despite excessive alcohol consumption, with beneficial effects on mitochondrial function (the cell’s main energy producer) and possible implications for inflammation and age-related intestinal injuries. 


Model: Mice with obstructed nephropathy
Dosage: NAD+ (i.p.) 100 μg/mouse/day

NAD+ Decline Identified as a Therapeutic Target for Kidney Injury

Beijing researchers show that pediatric patients with a leading cause of kidney injury have dysregulated levels of NAD+ and that mice with obstructed kidneys treated with NAD+ have reduced kidney damage.


Model: C57BL/6 mice
Dosage: Mice received 1 × 1011 vg dose of AAV1.tMCK.NT-3, via intramuscular (IM) injection into the gastrocnemius muscle

New Hospital Study Shows Gene Therapy Reverses Muscle Aging

Researchers show that targeting a growth factor gene in muscle preserves muscle integrity and physical fitness in mice with sarcopenia - the age-related loss of muscle mass and strength. 


Model: C57BL/6J male mice
Dosage: 500 mg/kg/day of NMN and 435 mg/kg/day of NR intraperitoneally injected for four consecutive days beginning two hours before cisplatin-induced kidney injury

Latest UPenn Study Reveals NMN and NR Have Similar Efficacy in a Kidney Disease Model

Supplementing with nicotinamide mononucleotide (NMN) or nicotinamide riboside (NR) confers comparable benefits against kidney disease in male mice.

(The study’s principal investigator, Dr. Katalin Susztak, MD, PhD | Emory Daily Pulse)

NMN and NR have similar effects in reducing molecular markers for kidney dysfunction in a mouse model for kidney disease.

Backed by the largest-ever individual investment towards a longevity startup from OpenAI CEO Sam Altman, Retro Biosciences will begin to tackle aging via cellular reprogramming, autophagy, and plasma-inspired therapeutics.   

Investor and OpenAI CEO Sam Altman | MIT Technology Review  

Scientists Identify Hallmarks of Aging that Can Be Reversed 

Twelve underlying drivers of aging can potentially be slowed, prevented, or reversed to improve health and extend lifespan. 

Investigators Dr. Guido Kroemer (left) and Dr. Carlos Lopez-Otin (right) | El Comercio 

Model: Mice
Dosage: low-dose nicotine administration in drinking water (2 μg/mL)

Study Shows Low-Dose Nicotine Can Protect the Brain from Aging

By bringing NAD+ levels back into balance, nicotine increased the number of brain cells generated and fought off cognitive decline in aging mice.

Model: Male Wistar rats (16-18 months old)
Dosage: Apremilast 5 mg/kg/day via I.P. injection for 3 consecutive days per week for 8 weeks
              Cilostazol 7.5 mg/kg/day via I.P. injection for 8 weeks

Anti-Inflammatory Drug Protects Against Alzheimer's, New Study Finds

Researchers find that the psoriasis drug apremilast (Apre) attenuates multiple features of Alzheimer’s disease in diabetic rats with learning deficits. 


What is NMN?

Nicotinamide mononucleotide (NMN) increases blood levels of nicotinamide adenine dinucleotide (NAD+) to alleviate age-related disorders like metabolic disease and cardiovascular dysfunction.

(Nicotinamide mononucleotide [NMN] molecular structure)

Nicotinamide mononucleotide (NMN) is a precursor of the essential molecule for cell energy metabolism, DNA repair, and cell stress responses -- nicotinamide adenine dinucleotide (NAD+).

Scientists use stem cell therapy to improve heart function and reduce the risk of stroke and heart attack in heart failure patients.

Lead investigator, Emerson C. Perin, M.D., Ph.D. | The Texas Heart Institute 

Model: Sedentary men approximately 26 years of age 
Dosage: Steady-state exercise- 10 minutes of cycling at 60% VO2peak, or high-intensity interval exercise- 20 seconds of cycling at 120% VO2peak with 20-second rest in between up to 15 times

Senescent cell marker p16 is reduced in the thigh muscle of sedentary men 24 hours following high-intensity interval cycling but not steady-state cycling. 

Principle Investigator, Dr. Chia-Hua Kuo | Linkedin

Model: Human (middle age)
Dose: Calorie restriction (25%)

Clinical Study Shows Calorie Restriction Slows Pace of Aging in Healthy Adults

A first-of-its-kind clinical study from Columbia University's Mailman School of Public Health found that two years of calorie restriction slowed the human aging process.

Study Shows that NR Helps Prevent Alcohol-Induced Gut Injury

NAD+ Decline Identified as a Therapeutic Target for Kidney Injury

New Hospital Study Shows Gene Therapy Reverses Muscle Aging

Latest UPenn Study Reveals NMN and NR Have Similar Efficacy in a Kidney Disease Model

ChatGPT Founder Backed Bio Startup Aims to Reverse Aging

Scientists Identify Hallmarks of Aging that Can Be Reversed

Study Shows Low-Dose Nicotine Can Protect the Brain from Aging

Anti-Inflammatory Drug Protects Against Alzheimer's, New Study Finds

What is NMN?

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Stem Cell Therapy Improves Heart Function and Reduces Risk of Stroke and Heart Attack: Largest Human Trial of its Kind

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