Seragon’s RESTORIN and the Evolution of Aging Interventions Containing NAD+ Precursors

Aging interventions that include NAD+ precursors have evolved, adding components targeting various hallmarks of aging, from inflammation to cell waste elimination.

Some aging intervention products with NAD+ precursors, like Seragon’s Restorin, have evolved to include additional components targeting multiple hallmarks of aging.

Aging &amp; Longevity

Removing an NAD+ transporter called SLC25A51 from insulin-secreting cells mitigates diabetes and reduces senescent cells — cells that contribute to the pathology of age-related diseases.  


Principal investigator Nora Kory, PhD, from Harvard University (image: harvard.edu). 

Model: 24-month-old male and female C57BL/6J mice
Dosage: 3 mg/kg/day, delivered continuously over 8 weeks

Diabetes Drug Elamipretide Reverses Muscle and Heart Aging: New Study Reveals

Scientists show that elamipretide restores muscle and heart function in aging mice but doesn’t affect epigenetic or transcriptomic age.


Cardiovascular

Model: Naturally aged C57BL/6J mice

Can Intermittent Fasting Slow Down Gut Aging? New Research Suggests So

A new study provides data suggesting compromised intestinal function with age and that fasting for short periods promotes intestinal regeneration and function in aged mice.

(A dysfunctional intestinal barrier that leaks harmful substances and bacteria into circulation develops with age | The Amino Company)

Alternate-day fasting, a form of intermittent fasting, reverses age-related intestinal barrier leakage in old mice.

Participants: healthy adults between the ages of 50 and 81
Dosage: 5 mg/week or 10 mg/week of rapamycin

One of the most potent anti-aging compounds rapamycin — an FDA-approved drug that inhibits mTOR — increases the lean body mass of older women while reducing their pain. 


Senior investigator Sajad Zalzala, MD (image: cnbc.com)

Clinical Trials

Cognitive deficits were reduced by 52% in Alzheimer’s disease patients receiving transcranial magnetic stimulation (TMS) — a technique that stimulates the brain’s electrical activity. 


Lead researcher Giocomo Koch, MD, PhD, uses a TMS device on an individual wearing an electroencephalogram (EEG) cap (image: domussantarita.it). 

Brain &amp; Neurons

The most comprehensive brain model reveals that combining NAD+ (nicotinamide adenine dinucleotide) supplementation with diet and exercise powerfully modulates brain aging. 


Model: Type 2 diabetic rats induced by high-fat diet and low-dose streptozotocin (STZ) Dosage: 0.2 mg/kg liraglutide administered daily for 8 weeks

Weight Loss Drug Protects Against Diabetic Sarcopenia: New Study Finds

Researchers show that liraglutide protects muscle from diabetes-induced atrophy by reversing cellular aging and activating the YAP/TAZ signaling pathway.

Diabetes &amp; Obesity

Longevity Fanatic Bryan Johnson’s Daily Aging Intervention Routine for 2025

Aging guru Bryan Johnson shares his latest daily longevity protocol, which he uses to optimize measurements of his body’s aging.

(A futuristic image of Bryan Johnson | YouTube)

Venture capitalist and aging guru Bryan Johnson reveals his latest longevity-focused daily routine for 2025, focusing on sleep, exercise, and eating well.

The longevity gene klotho prolongs the lifespan of mice while preventing muscle, bone, and brain aging. 

Miguel Chillón, PhD, and Laura Rodriguez-Estevez, researchers from Universitat Autònoma de Barcelona in Spain, who conducted the study (image: uab.cat) 

Seragon’s RESTORIN and the Evolution of Aging Interventions Containing NAD+ Precursors

Harvard Scientists Unravel the Role of NAD+ Transporter in Mitigating Age-Related Diabetes

Diabetes Drug Elamipretide Reverses Muscle and Heart Aging: New Study Reveals

Can Intermittent Fasting Slow Down Gut Aging? New Research Suggests So

Anti-Aging Supplement Rapamycin Increases Muscle and Reduces Pain: New Results

Jumpstarting the Brain Reduces Alzheimer’s Progression by 52% in New Phase II Trial.

Most Comprehensive Study Places NAD+ at Forefront of Countering Brain Aging

Weight Loss Drug Protects Against Diabetic Sarcopenia: New Study Finds

Longevity Fanatic Bryan Johnson’s Daily Aging Intervention Routine for 2025

One-Time Anti-Aging Gene Therapy Treatment Prolongs Life by 20%, New Study Shows