Model: C57BL/6 Ercc1 +/- mice
Dosage: 11% oxygen chamber

Breaking News: Harvard Study Shows Lower Oxygen Levels Drive Longer Lifespan 

Researchers show that oxygen restriction (hypoxia) increases median lifespan by approximately 50% and improves motor coordination in mice modeling accelerated aging. 


Aging &amp; Longevity

Model: Male C57BL/6 J 
Dosage: 5 mM spermidine in drinking water

Spermidine Boosts Blood Flow and Promotes Cardiovascular Health

Supplementing aged and young mice with spermidine increases muscle blood vessel growth and blood flow, implying improved cardiovascular health and exercise performance. 


Corresponding investigator Koji Ikeda, M.D., Ph.D. | Research Gate 

Cardiovascular

Model: 18-month-old CD45.2 mice
Dosage: 4 ug Netrin-1 via injection; 5 injections total; once every 35 days

Researchers Rejuvenate Aged Mouse Blood Stem Cells

Infusing blood with a molecule critical for development, Netrin-1, improves the bone marrow niche in older people and restores the function of older blood stem cells, which has the potential to help people live longer.


Basic Research

Model: Zebrafish, tert -/-
Dosage: Telomerase activation

Study Shows Telomerase Activation in Gut Has Limited Anti-Aging Effects on Healthy Fish

Fish lacking an enzyme critical for maintaining telomere length, telomerase, had severe aging and a shortened lifespan, whereas persistent activation of telomerase in the gut of healthy zebrafish had only small improvements in their healthspan.


Iranian scientists find that liver cell death and fat accumulation are synergistically diminished by metformin and resveratrol in human cells by activating the longevity-mediating SIRT1 enzyme. 


Abstract depiction of researchers at Shahid Beheshti University of Medical Sciences (rendered by Midjourney). 

Metabolism

By 2024, SirTLab aims to begin human testing of therapies that activate SIRT6, an enzyme shown to extend the lifespan of mice. 


Depiction of SIRT6 enzyme bound to the senolytic quercetin (blue & red balls) and ADP-ribose (green & red balls) | Wikipedia

Industry

Cell Reprogramming: True Age Reversal Technology

A gene manipulation technique called cellular programming extends the lifespan of mice and reverses signs of aging in multiple studies, leading to large financial investments in this new technology.  


A stem cell visualized under the microscope with fluorescence. (shutterstock.com | DrimaFilm)

Unlocking the Fountain of Youth: Maximizing NAD+ Levels with Precursors

Nicotinamide adenine dinucleotide (NAD+) levels decline with age, which has been linked to age-related conditions, yet NAD+-boosting precursors can replenish this essential molecule.

Maximizing NAD+ levels with the precursors tryptophan, nicotinic acid, nicotinamide, NMN, or NR can alleviate age-associated diseases like cardiovascular ailments and neurodegenerative conditions.

Revitalizing Aging: Clearing Troublesome Senescent Cells with Senolytics for Optimal Health

Senolytics selectively eliminate senescent cells — non-proliferative cells that release inflammatory molecules to surrounding tissue triggering otherwise healthy cells to enter senescence.

Senolytics, including dasatinib and quercetin along with fisetin, selectively eliminate aged, non-proliferative cells (senescent cells) to revitalize organ health and alleviate age-associated diseases.

Model: Male C57BL/6 mice injected with D-galactose to accelerate aging 
Dose: 100 mg/kg aminoguanidine or 40 mg/kg resveratrol injections

Resveratrol — a naturally occurring anti-aging compound — preserves kidney structure, prevents dysfunction, and quenches harmful senescent cells in age-accelerated mice. 

Abstract depiction of scientist holding a microscope slide with kidney sample (generated by Midjourney).

Breaking News: Harvard Study Shows Lower Oxygen Levels Drive Longer Lifespan

Latest Study Shows Spermidine Significantly Boosts Blood Flow & Promotes Cardiovascular Health

Researchers Rejuvenate Aged Mouse Blood Stem Cells

Study Shows Telomerase Activation in Gut Has Limited Anti-Aging Effects on Healthy Fish

Study Reveals Synergistic Power of Metformin and Resveratrol in Combating Liver Deterioration

Biotech Startup SirTLab Prepares for Groundbreaking Human Trials of SIRT6-Boosting Therapy

The Emergence of Cellular Reprogramming: True Age Reversal Technology

Unlocking the Fountain of Youth: Maximizing NAD+ Levels with Precursors for Age-Defying Disease Prevention

Revitalizing Aging: Clearing Troublesome Senescent Cells with Senolytics for Optimal Health

Taiwanese Study Reveals Resveratrol’s Remarkable Role in Kidney Health and Senescent Cell Reduction