The interventions that may help fix or reset circadian rhythms, which decline with age. 

A representation of Kairos, not to be confused with Kronos (original image: misel-trogir.com).

Aging &amp; Longevity

Innovative Computer Model Reveals Aging May Stem from Lost Cellular Purpose

A new computer simulation suggests aging occurs when cells and tissues lose their developmental goals, offering a fresh perspective on rejuvenation strategies.

(The article’s principal investigator, Michael Levin | Tufts Now)

An innovative computer model simulates aging, suggesting that cells and tissues lose their developmental goals, leading to physiological deterioration.

NAD+ (nicotinamide adenine dinucleotide) may contribute to healthy cellular aging by enhancing biological energy flow, according to the newly formulated energy resistance principle.


Model: Male Sprague-Dawley rats 
Dosage: 400 mg/kg of magnesium L-theanine and 600 mg/kg of nicotinamide riboside administered orally for 40 days

Scientists find that treating rats with magnesium L-theanine and nicotinamide riboside (NR) counteracts stress-induced metabolic, gut, and liver aging. 

Study conducted by researchers from Firat University in Turkey (image: turkeyuniversity.org)

The Latest Insight on Anti-Aging Therapeutics Targeting Cardiovascular Disease

According to French scientists, no organ system appears as vulnerable to aging as the cardiovascular system, and anti-aging therapeutics may help mitigate the effects of cardiovascular disease.

(The principal investigator behind the review, aging researcher Guido Kroemer | Olympiad in Cardiovascular Medicine)

Anti-aging therapeutics may prevent and slow age-related cardiovascular dysfunction.

Cardiovascular

How American Country Music Icon Willie Nelson Has Defied Age Limitations into His 90s

Country music legend Willie Nelson practices martial arts to maintain physical function, keeps a positive outlook, and eats low amounts of food for astounding longevity.

(Willie Nelson [with American flag bandana] plays alongside Walon Jennings [left] and Johnny Cash [right] | YouTube)

Country music icon Willie Nelson does martial arts, stays positive, and keeps his calorie intake low for optimal aging into his 90s.

In remembrance of Jane Goodall: The science-backed lifestyle factors that likely contributed to her long life and sound mind.  

Jane Goodall, PhD (image: thenationalnews.com).

Participants: Healthy males (age range: 70-76)
Dosage: 1 mg/kg/day of rapamycin for 8 weeks

Supplementing with rapamycin leads to improvements in cardiac and vascular function in older men, suggesting this longevity-associated drug may counteract cardiovascular aging. 

Nicolas Musi, MD, professor of medicine and an author of the study (image: sanantoniomag.com). 

Model: Aged mice (18 months old) underwent exploratory laparotomy under isoflurane anesthesia to induce POCD.
Dosage: Berberine was given by oral gavage at 100 mg/kg per day for 14 days after surgery.

Ancient Plant Compound Shows Promise for Protecting the Aging Brain 

Study shows berberine, a natural plant compound, protects memory in aging mice after surgery by reducing brain inflammation, stress, and cell damage.


Brain &amp; Neurons

University of California (UC) Berkeley scientists moderately extend the lifespan of old mice by giving them oxytocin (sometimes called the "love hormone") and a compound that inhibits inflammation.  

Beyond Aligning Life with Light: Supplements that Counter Circadian Decline

Innovative Computer Model Reveals Aging May Stem from Lost Cellular Purpose

Boosting NAD+ May Defy Aging by Enhancing Energy Flow, According to a New Theory

New Research: Magnesium, L-Theanine, NAD+ Combo Counters Stress Aging

The Latest Insight on Anti-Aging Therapeutics Targeting Cardiovascular Disease

How American Country Music Icon Willie Nelson Has Defied Age Limitations into His 90s

Remembering Jane Goodall: The Simple Habits That Kept Her Mind Sharp for 91 Years

Longevity Drug Rapamycin Improves the Heart of Older Adults, New Study Shows

Ancient Plant Compound Shows Promise for Protecting the Aging Brain

New UC Berkeley Study: “Love Hormone” and Anti-Inflammatory Combo Extend Life