A natural supplement, quercetin, targets age-promoting senescent cells, reduces inflammation, and counteracts blood vessel aging in men with heart disease. 

university

University

Study conducted at the University of Montreal in Quebec, Canada (image: ledevoir.com) 

Clinical Trials

Participants: Healthy middle-aged adults (average age: 55)
Dosage: 100 mg/day of Monarda didyma L. extract, preferably at lunchtime with plenty of water, for 12 weeks

An extract made from Monarda didyma L. reduces the biological age of older adults while improving their quality of life. 

monarda_didyma

Monarda_Didyma

A flower from the Monarda didyma L. plant (image: nativeplanttrust.org) 

Participants: healthy adults between the ages of 50 and 81
Dosage: 5 mg/week or 10 mg/week of rapamycin

One of the most potent anti-aging compounds rapamycin — an FDA-approved drug that inhibits mTOR — increases the lean body mass of older women while reducing their pain. 


sajad

Sajad

Senior investigator Sajad Zalzala, MD (image: cnbc.com)

Model: Humans aged 50 to 90 years with mild cognitive impairment or mild dementia due to Alzheimer’s disease
Dosage: 10 mg/kg lecanemab once every two weeks via intravenous (vein) injection
&nbsp;

Breakthrough Alzheimer's Treatment Achieves Historic FDA Stamp of Approval

In June of 2023, The FDA granted the drug lecanemab (leqembi) traditional approval for the treatment of Alzheimer’s. 

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Washington,,D.c.,,Usa-,January,13,,2020:,Fda,Sign,Outside,Their

Brain &amp; Neurons

Model: Human chronic kidney disease patients with an average age of 60
Dosage: 1,000 mg per day of NR by pill for six weeks; 1,200 mg per day of CoQ10 by pill for six weeks

NR and CoQ10 Improve Kidney Function: Latest Study

A kidney disease patient study reveals nicotinamide riboside (NR) increases intermediate molecules of metabolism, and NR and coenzyme Q10 (CoQ10) both reduce harmful fats.

davis

DAVIS

(University of California, Davis | theaggie.org)

NR significantly increases mitochondrial metabolism molecular intermediates, while both NR and CoQ10 improve lipid metabolism profiles, both suggesting metabolic improvements.

Model: Human (middle age)
Dose: Calorie restriction (25%)

Clinical Study Shows Calorie Restriction Slows Pace of Aging in Healthy Adults

A first-of-its-kind clinical study from Columbia University's Mailman School of Public Health found that two years of calorie restriction slowed the human aging process.

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New,York,,Usa,-,July,13,,2016:,Life,In,Columbia

Model: Humans aged 40 to 65 years
Dosage: 300 mg, 600 mg, or 900 mg of NMN per day for 60 days

New Study Shows NMN Substantially Increases NAD+ and Enhances Physical Performance

NMN increases blood NAD+, enhances walking distance over a six-minute period, and improves a self-assessed evaluation of health, especially at higher doses in healthy adults.

nmn-graphics-charts-figure-1-1200x651

NMN triggers higher blood NAD+ levels, along with improved muscle function and overall health and wellbeing.

Model: Adults with non-alcoholic fatty liver disease
Dosage: 250 mg nicotinamide riboside and 50 mg pterostilbene per day or 500 mg nicotinamide riboside and 100 mg pterostilbene per day

NAD+ Booster Combo Reduces Inflammation in Liver Disease

MIT professor Leonard Guarente leads a study showing nicotinamide riboside (NR) and pterostilbene reduce inflammatory markers in adults with non-alcoholic fatty liver disease (NAFLD).

guarente

Leonard Guarente PhD

(Senior author and founder of Elysium Health Leonard Guarente, PhD | Ageist)

A NR and pterostilbene combination supplement reduces the abundance of blood markers for liver inflammation and a toxic fat that contributes to liver disease.

Model: female E4FAD mice 
Diet: Day 1 = 55% fat, 36% carbohydrate, and 9% protein. Day 2-5 = 43.3% fat, 47.4% carbohydrate, and 9.3% protein.

Fasting-Mimicking Diet Reduces Alzheimer’s Pathology

Feeding Alzheimer’s model mice a diet low in protein but high in fats reduces brain inflammation, restores new neuron production, and improves cognition. 


volter

Volter

Senior author, Dr. Volter D. Longo | USC Pressroom 

Model: Human older adult
Dosage: 1000 mL of plasma each week for 10 weeks

Young Blood Improves Kidney Function and Reverses Biological Age

Older adults receiving plasma from umbilical cord blood exhibit improved kidney function and decreased morbidity and mortality risk based on age-related DNA changes.


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Doctor,In,Blue,Gloves,Keep,In,Hands,Test,Tube,With

Tube of plasma (yellow) separated from blood | Lilja Malanjak (shutterstock.com)

Old Adults: (70-80 years old) ; Young Adults: (20-30 years old)
GlyNAC: capsules containing glycine (1.33 mmol/kg/day) and N-acetylcysteine (0.81 mmol/kg/day) once a week for 24 weeks

Signs of Aging Significantly Reversed with Antioxidant Cocktail 

Clinical trial results show that glycine and N-acetylcysteine (GlyNAC) improves cognition, boosts physical performance, and mitigates insulin resistance in older adults. 


kumar3

KUMAR3

Corresponding author, Dr. Rajagopal V. Sekhar | Baylor College of Medicine 

Clinical trial results show that glycine and N-acetylcysteine (GlyNAC) improves cognition, boosts physical performance, and mitigates insulin resistance in older adults. 

A Natural Senolytic Supplement Curbs Heart Aging in New Clinical Trial

Flower Extract Slows Cellular Aging & Improves Life Quality, New Study Shows

Anti-Aging Drug Rapamycin Increases Muscle and Reduces Pain: New Results

Breakthrough Alzheimer’s Treatment Achieves Historic FDA Stamp of Approval

NR and CoQ10 Improve Kidney Function: Latest Study

Clinical Study Shows Calorie Restriction Slows Pace of Aging in Healthy Adults

New Human Study Shows NMN Substantially Increases NAD⁺ and Enhances Physical Performance

Elysium Scientists Combine NAD⁺ Booster with Sirtuin Activator to Reduce Inflammation in Liver Disease

USC Scientists Reveal that Fasting-Mimicking Diet Reduces Brain Pathology and Cognitive Decline in Alzheimer’s

UCLA Scientists Show Young Blood Improves Kidney Function and Reverses Biological Age

Baylor College Scientists Reverse Signs of Aging with Antioxidant Cocktail in Older Adults