In a human clinical trial, Yale scientists find that caloric restriction prevents thymus shrinkage and changes the inflammatory profile of fat tissue. 

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<ul>
<li style="font-weight: 400;" aria-level="1">Cultured human lung fibroblasts with five types of senescence: Etoposide,  P16INK4a over-expression, KRAS, replicative, and UV</li>
<li style="font-weight: 400;" aria-level="1">Irradiated or naturally aged (24 months old) mice were treated with mock- or mNKG2D-CAR T; irradiation-accelerated mouse model of aging, wild-type C57BL/6 mice (8 to 10 weeks old)</li>
<li style="font-weight: 400;" aria-level="1">Three rhesus macaques and two cynomolgus macaques</li>
</ul>

Engineered Immune Cells Can Hunt Down and Eliminate Aging Cells

A study demonstrates that engineered immune cells can serve as potent and selective medicine for cells at the center of aging and age-associated diseases. 


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A study demonstrates that engineered immune cells can serve as potent and selective medicine for cells at the center of aging and age-associated diseases. 

Participants: Overweight women aged 64 ± 18
Dosage: 20 g of olive oil (mostly monounsaturated fat) in place of margarine in the morning

Certain Fats for Breakfast Reduce Inflammation

Older women who ate olive oil or margarine with breakfast had fewer circulating inflammatory molecules than those who ate butter, suggesting which fat is better for cardiovascular aging. 


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Immunity

An immune system enzyme called CD38 is associated with low NAD+ levels, shortened reproductive lifespan, and fertility problems in female mice.  


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Models:
<ul>
<li style="font-weight: 400;" aria-level="1">Cultured human lung fibroblasts with five types of senescence: Etoposide,  P16INK4a over-expression, KRAS, replicative, and UV</li>
<li style="font-weight: 400;" aria-level="1">Irradiated or naturally aged (24 months old) mice were treated with mock- or mNKG2D-CAR T; irradiation-accelerated mouse model of aging, wild-type C57BL/6 mice (8 to 10 weeks old)</li>
<li style="font-weight: 400;" aria-level="1">Three rhesus macaques and two cynomolgus macaques</li>
</ul>
Dosage: NKG2D-CAR T cells

Scientists Engineer Immune Cells that Can Hunt Down and Eliminate Aging Cells

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Model: HSCs derived from the bone marrow of anonymous old adults (58–77 years old); Old mice (81–84 weeks old).
Dosage: Old mice were fed with a control (black) or urolithin A (UA) supplemented (red) diet (50 mg kg/day) for 16 weeks.

Urolithin A Can Revitalize Blood Stem Cells in People and Mice, Study Finds 

This mitochondrial modulator helps old human blood stem cells grow and copy themselves more efficiently, and it also helps blood stem cells make blood and immune systems for old mice. 


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UA pom pic

Model: Male C57BL/6 mice exposed to lipopolysaccharide (LPS) to induce septic shock
Dosage: 40 mg NAD+ (probably injected, but not clear from the publication)

NAD+ reduces inflammation and increases the survival of mice subjected to an overactive immune response known as sepsis. 


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Lead investigator Dr. Jasper Iske | LinkedIn

Discover groundbreaking insights from Harvard scientists as they unveil the incredible role of NAD+ in modulating the immune system. Explore how this powerful mechanism acts as a shield, protecting the body against inflammatory threats. Dive into the science at NAD.com/news.

Unlocking Immune Power: Harvard Scientists Reveal How NAD+ Modulates the Immune System to Guard Against Inflammatory Assault

Hiroshima and Nagasaki bombing survivors exhibit accelerated immune system aging, including reduced immune cells and higher levels of reactive oxygen species (ROS) — molecules that harm cells in excess. 


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Explore a groundbreaking Japanese study that uncovers a profound connection between atomic bomb radiation and the hastened aging of the immune system. Delve into the enduring repercussions of nuclear warfare, shedding light on the lasting impact of historical events on human health.

Japanese Study Reveals: Atomic Bomb Radiation Linked to Accelerated Immune System Aging – Unveiling Nuclear War's Lingering Effects

A study published in Nature by the University of Minnesota shows that the same lineage of mouse immune cells can continually divide over multiple lifespans.

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JDimmunmain

T cells demonstrate remarkable replication ability and longevity, surpassing their host's lifespan, with implications for cell-based therapies and aging research.

Model: D-gal artificially-aged mice
Dosage: 25 mg/kg intraperitoneal injections of C3G twice a week for 4 weeks

Plant Pigment Reduces Age-Related Inflammation and Boosts NAD+ 

The pigment cyanidin-3-O-glucoside (C3G) reduces inflammatory markers and boosts NAD+ in a mouse model for aging while reducing senescence in a cell model for aging. 

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(Elderberries contain abundant cyanidin-3-O-glucoside | Jaye Thompson)

Model: female C57BL/6 mice
Dose: 350 mg/kg per day of metformin in drinking water

Metformin Protects Against Reproductive Aging

Ovarian fibrosis (scarring) – a hallmark of ovarian aging – is prevented when mice are given metformin, a common anti-diabetes medication.


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Senior author, Dr. Barbara C. Vanderhyden | University of Ottawa 

Female KunMing Mice (2 months old, weight 20~25 g)
Metformin: 100 or 300 mg/kg/day for 6 weeks

Metformin Reverses Age-Related Immune System Decline 

Researchers from Zhengzhou University utilize metformin to attenuate the degeneration of the thymus - an immune organ that plays a vital role in the development and function of immune fighting cells (T cells). 


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Bracknell,,England,-,January,14,,2014:,A,Box,Of,Metformin

Metformin, a diabetes drug, shows promise in preserving thymus function and structure in aging mice by enhancing mitochondrial function and reducing senescent cells.

BALB/c (female, 8-12 weeks) mice
Free NAD+ (20 mg/kg)
NAD+-LP-CaP (20 mg/kg)

 NAD+ Nanoparticles Increase Survival from Sepsis by Over Fourfold 

University of Wisconsin researchers utilize nano-sized fat particles (lipid nanoparticles) loaded with NAD+ to increase survival, rescue immune cells, and preserve energy production. 


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Madison,,Wi,-,October,29,,2021:,University,Of,Wisconsin,Logo

NAD+ loaded lipid nanoparticles significantly increase survival in septic mice, prevent immune cell death, and restore energy levels in critical organs, showing promise for sepsis treatment.

Model: Aged male C57Bl/6 mice
Dosage/Administration: 1 microgram/kilogram intravenous injection S100p1-G

Scientists find a metabolite secreted by gut bacteria in aged mice that can be blocked to prevent cognitive deficits.

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Xiang Zhang PhD

Co-Author, Dr. Xiang Zhang | University of Louisville

Swedish scientists find that electrical stimulation of the vagus nerve resolves (stops/ends) inflammation by increasing specialized fatty acids derived from omega-3s in mice.  


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Bacteria from a Young Gut Reverse Age-Related Inflammation

Fecal matter transplants from young mice could positively affect inflammation in the eyes, brains, and intestines of aged mice by affecting gut microbiota composition.

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Gut bacteria from young mice has been shown to reverse age-related inflammation in mice.

Killer Immune Cells Supress the Root of Aging 

Chinese scientists find that immune cell treatment diminishes senescence — considered the root of aging — in human tissue, an effect enhanced by elevating the neurotransmitter dopamine in aged mice. 


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Potent NAD+ Booster Promotes Inflammation

Study shows that the NAD+ precursor NRH (dihydronicotinamide riboside) is more potent than other NAD+ precursors but activates genes associated with inflammation. 


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The Mayo Clinic has discovered that NRH, but not other NAD+ precursors, increases NAD+ levels in immune cells, causing inflammation.

Absence of Transporter Protein Increases Lifespan and Improves Memory

Belgian scientists find that genetically deleting xCT – an amino acid transporter that brings cystine into and takes glutamate out of cells – in mice increases lifespan and improves memory.

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Why does NAD+ Drop During Aging?

The chronic inflammation induced by senescent cells depletes NAD+, leading to the organ dysfunction characteristic of aging and age-related disease.  

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A new study shows that fisetin, a senolytic compound, reduces depression-like behavior in mice with brain inflammation.

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A senolytic medication that destroys growth-arrested brain cells is being used by Japanese researchers to treat depression in lupus patients.

Researchers suggest that supplementation with nutritional and pharmacological interventions like NR and NAM can combat coronavirus infection.

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A study indicates that supplementing with nutritional interventions like NR and NAM can mitigate the coronavirus infection.

Enhancing NAD+ levels May Boost Innate Immunity to Coronaviruses | NMN

Others

Researchers propose that increasing NAD+ levels improves immune function in COVID-19 infection.

flying-purple-virus-molecules-microscopic-detail-on-abstract-bright-cold-background

Flying purple virus molecules microscopic detail on abstract bright cold background.

Researchers propose that the NAD+ molecule plays a key role in the immune response to viral infections, which include COVID-19.

NAD+ Levels May Modulate Immune Response to COVID-19

Niacin (vitamin B3) triggers immune cells to attack human brain tumor initiating cells.

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Brain Tumor

Niacin, also called vitamin B3, stimulates immune cells to attack cells that initiate human brain tumors.

Caloric Restriction Decreases Inflammation in Humans

Engineered Immune Cells Can Hunt Down and Eliminate Aging Cells

Olive Oil and Margarine Beat Butter in Breakfast Battle for Reducing Inflammation: Spanish Study

Buck Institute Study Shows Low NAD+ Drives Reproductive Aging and Hinders Fertility

Scientists Engineer Immune Cells that Can Hunt Down and Eliminate Aging Cells

Urolithin A Can Revitalize Blood Stem Cells in People and Mice, Study Finds

Harvard Scientists Find NAD⁺ Protects Against Life-Threatening Inflammation

Japanese Study Links Radiation with Accelerated Immune Aging: Nuclear Power’s Lasting Impact

Immune Cells Can Avoid Aging to Produce Progeny 30,000x the Earth’s Volume

Researchers find Plant Pigment that Reduces Age-Related Inflammation and Boosts NAD⁺

Anti-Diabetes Drug Metformin Protects Against Reproductive Aging in Latest Study

New Study Shows Metformin Reverses Age-Related Thymus Degeneration by Boosting Mitochondrial Function

New Study Shows NAD⁺ Nanoparticles Increase Survival from Sepsis by Over Fourfold in Mice

Researchers Find Blocking Gut Metabolite Prevents Cognitive Decline

Study from Sweden Suggests Nerve Stimulation Device Could Slow Aging

Study Shows Gut Bacteria from Young Mice Reverses Age-Related Inflammation

Dopamine Enhances Immune Cell Response Against Senescent Cells

Mayo Clinic Finds Potent NAD⁺ Booster Promotes Inflammatory Response

Study Shows that Deleting the Protein-Building Block Transporter xCT Increases Lifespan and Improves Memory in Mice

What Drives Aging?

Japanese Researchers Show Fisetin Alleviates Depression

Increasing NAD⁺ levels May Bolster Innate Immunity to Coronaviruses

Researchers Propose that Cellular NAD+ Levels Play Key Roles in the Immune Response to COVID-19

Activating Immune Cells with a Common Vitamin to Fight Off Deadly Brain Cancer