This NAD+ precursor shields the heart from injury caused by a chemotherapeutic in rats, preventing the disruption of tissue organization and blood pumping abilities.

womanwithcancerduringchemotherapyrecoveringfromillnessinhospital

Woman,With,Cancer,During,Chemotherapy,Recovering,From,Illness,In,Hospital

Supplementing with NMN protects the heart against chemotherapy-induced heart complications that include disrupted tissue organization and blood pumping abilities.

Model: Naturally aged 24-month-old C57BL/6 mice 
Dose: 0.1 mg/kg/day of folic acid administered orally for 12 months

Supplementation with vitamin B9, also known as folic acid or folate, prevents cellular senescence and slows vascular aging in naturally aged mice.  

battle

Battle

Cardiovascular

Model: Male ApoE−/− mice fed a high-fat diet for 12 weeks to induce atherosclerosis.
Dosage: Methyl-β-cyclodextrin (Mß-CD) at 2.0 g/kg, subcutaneous injection, twice a week

 A new study shows cyclodextrin reduces artery plaques in mice by lowering cholesterol and blocking inflammatory cell death. 

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Untitled-design-13

The Latest Insight on Anti-Aging Therapeutics Targeting Cardiovascular Disease

According to French scientists, no organ system appears as vulnerable to aging as the cardiovascular system, and anti-aging therapeutics may help mitigate the effects of cardiovascular disease.

kroemer

Kroemer

(The principal investigator behind the review, aging researcher Guido Kroemer | Olympiad in Cardiovascular Medicine)

Anti-aging therapeutics may prevent and slow age-related cardiovascular dysfunction.

Participants: Healthy males (age range: 70-76)
Dosage: 1 mg per day of rapamycin for 8 weeks

Supplementing with rapamycin leads to improvements in cardiac and vascular function in older men, suggesting this longevity-associated drug may counteract cardiovascular aging. 

musi

Musi

Nicolas Musi, MD, professor of medicine and an author of the study (image: sanantoniomag.com). 

α-Lipoic Acid: Efficacy, Safety, and Dosage

α-lipoic acid is an antioxidant naturally produced by the body, which is also available as a supplement, and human trials indicate that it has neuroprotective and male fertility-enhancing effects.

alpha-lipoic-acid

alpha-lipoic acid

(α-lipoic acid’s molecular structure | Neuroneeds)

α-lipoic acid is a potent antioxidant, which human trials suggest has neuroprotective and male fertility-enhancing properties.

Metabolism

A Harvard-Trained Doctor’s Top 5 Anti-Aging Supplements

An aging research aficionado, Dr. Josh Helman, shares five supplements that can help fight the effects of aging: nitric oxide, NMN, honokiol, modified citrus pectin, and creatine.

josh-helman

Josh Helman

(Harvard-trained aging expert, Dr. Josh Helman | Jupiter Medical Center)

Harvard-trained aging expert Dr. Josh Helman unveils his top five supplements to fight against aging.

Aging &amp; Longevity

A high but not low dose of nattokinase is associated with reducing artery plaque size by 36% in older adults. 

ultrasound

Ultrasound

An ultrasound of the carotid artery with arrows pointing to plaques (image: avicennacardiology.com). 

Model: 8 adults with peripheral artery disease 
Dosage: 1,000 mg of NR daily for four weeks

New Study Suggests NR Modestly Improves Cognition in Age-Related Vascular Disease

Taking NR was associated with improved blood flow to a specific brain region following cognitive stimulation, as well as trends toward enhanced cognition in patients with age-related vascular disease.

andriy

Andriy

(The study’s principal investigator, Andriy Yabluchanskiy | LinkedIn)

Taking NR is associated with improved blood perfusion to a brain region involved in memory and daily task organization, as well as a trend toward enhanced cognition.

Brain &amp; Neurons

Discover proven anti-aging and longevity drugs that extend lifespan. Lifestyle, nutrition, sleep, exercise, and toxin avoidance, all in the best and most comprehensive guide.

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Explore the most effective longevity interventions—nutrition, fasting, sleep, exercise, and mouse-tested drugs that extend lifespan in real studies.

Longevity Prescription: Diet, Fasting, and Proven Anti-Aging Strategies

Model: 24-month-old male and female C57BL/6J mice
Dosage: 3 mg/kg/day, delivered continuously over 8 weeks

Diabetes Drug Elamipretide Reverses Muscle and Heart Aging: New Study Reveals

Scientists show that elamipretide restores muscle and heart function in aging mice but doesn’t affect epigenetic or transcriptomic age.


Rodent Study Shows NMN Protects the Heart from Chemotherapy Toxicity

New Study: Vitamin B9 Combats Cell Senescence to Slow Vascular Aging

Scientists Find a New Way to Stop Dangerous Artery Plaques From Growing

The Latest Insight on Anti-Aging Therapeutics Targeting Cardiovascular Disease

Longevity Drug Rapamycin Improves the Heart of Older Adults, New Study Shows

An Overview of α-Lipoic Acid: Efficacy, Safety, and Dosage

A Harvard-Trained Doctor’s Top 5 Anti-Aging Supplements

New Study Reveals: High-Dose Supplement Shrinks Arterial Plaque by 36%

New Study Suggests NR Modestly Improves Cognition in Human Subjects

Longevity Prescription

Diabetes Drug Elamipretide Reverses Muscle and Heart Aging: New Study Reveals