In a human clinical trial, Yale scientists find that caloric restriction prevents thymus shrinkage and changes the inflammatory profile of fat tissue. 

heart

A vaccine targeting an enzyme that breaks down NAD+, called CD38, counteracts signs of aging in mice. 


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Medical disposable syringe for vaccine injection and glass vial.

Immunity

A description of inflammaging and related anti-aging strategies. 


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Claudio

Dr. Claudio Franceschi, the man who coined the term inflammaging (image: u-bordeaux.fr)

Discover proven anti-aging and longevity drugs that extend lifespan. Lifestyle, nutrition, sleep, exercise, and toxin avoidance, all in the best and most comprehensive guide.

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Explore the most effective longevity interventions—nutrition, fasting, sleep, exercise, and mouse-tested drugs that extend lifespan in real studies.

Longevity Prescription: Diet, Fasting, and Proven Anti-Aging Strategies

Aging &amp; Longevity

NAD+ Supercharges Immune System Recovery in Older Mice

Researchers from the University of California, Berkeley, found that young mice need NAD+ breakdown, while old mice need NAD+ boosting.

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Berkeley

Model: C57BL/6J mice and Abca1/g1-m/-m mice of both sexes and bone marrow-derived macrophages from C57BL/6J and Abca1/g1-m/-m mice
Dosage: 300 mg/kg of NMN by daily intraperitoneal injection for two weeks, 5 mg/kg of dasatinib and 50 mg/kg of quercetin by oral gavage for five consecutive days every two weeks for three months, and a 500 μM concentration of NMN for bone marrow-derived macrophages in laboratory dishes

Revitalizing Immune Cells & Eye Function: NMN Study Unveils Remarkable Findings

A new study suggests that NMN reverses an age-associated dysfunctional cellular state — senescence — in immune cells and restores eye function in an age-related eye disease mouse model.

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AMD_EYE

(An anatomical view of an eye with age-related macular degeneration | NAD.com)

NMN reverses an age-related dysfunctional state in immune cells — senescence — and improves eye function in an age-related eye disease mouse model.

<ul>
<li style="font-weight: 400;" aria-level="1">Cultured human lung fibroblasts with five types of senescence: Etoposide,  P16INK4a over-expression, KRAS, replicative, and UV</li>
<li style="font-weight: 400;" aria-level="1">Irradiated or naturally aged (24 months old) mice were treated with mock- or mNKG2D-CAR T; irradiation-accelerated mouse model of aging, wild-type C57BL/6 mice (8 to 10 weeks old)</li>
<li style="font-weight: 400;" aria-level="1">Three rhesus macaques and two cynomolgus macaques</li>
</ul>

Engineered Immune Cells Can Hunt Down and Eliminate Aging Cells

A study demonstrates that engineered immune cells can serve as potent and selective medicine for cells at the center of aging and age-associated diseases. 


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A study demonstrates that engineered immune cells can serve as potent and selective medicine for cells at the center of aging and age-associated diseases. 

Participants: Overweight women aged 64 ± 18
Dosage: 20 g of olive oil (mostly monounsaturated fat) in place of margarine in the morning

Certain Fats for Breakfast Reduce Inflammation

Older women who ate olive oil or margarine with breakfast had fewer circulating inflammatory molecules than those who ate butter, suggesting which fat is better for cardiovascular aging. 


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An immune system enzyme called CD38 is associated with low NAD+ levels, shortened reproductive lifespan, and fertility problems in female mice.  


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iscience logo 2

Models:
<ul>
<li style="font-weight: 400;" aria-level="1">Cultured human lung fibroblasts with five types of senescence: Etoposide,  P16INK4a over-expression, KRAS, replicative, and UV</li>
<li style="font-weight: 400;" aria-level="1">Irradiated or naturally aged (24 months old) mice were treated with mock- or mNKG2D-CAR T; irradiation-accelerated mouse model of aging, wild-type C57BL/6 mice (8 to 10 weeks old)</li>
<li style="font-weight: 400;" aria-level="1">Three rhesus macaques and two cynomolgus macaques</li>
</ul>
Dosage: NKG2D-CAR T cells

Scientists Engineer Immune Cells that Can Hunt Down and Eliminate Aging Cells

immune_cell_soldier

Model: HSCs derived from the bone marrow of anonymous old adults (58–77 years old); Old mice (81–84 weeks old).
Dosage: Old mice were fed with a control (black) or urolithin A (UA) supplemented (red) diet (50 mg kg/day) for 16 weeks.

Urolithin A Can Revitalize Blood Stem Cells in People and Mice, Study Finds 

This mitochondrial modulator helps old human blood stem cells grow and copy themselves more efficiently, and it also helps blood stem cells make blood and immune systems for old mice. 


Caloric Restriction Decreases Inflammation in Humans

Anti-Aging Vaccine Boosts Strength, Memory & NAD+ in New Study

What Is Inflammaging? And How to Reverse It

Longevity Prescription

NAD+ Supercharges Immune System Recovery In Older Mice, Hurts Blood Stem Cells of Young Mice

Revitalizing Immune Cells & Eye Function: NMN Study Unveils Remarkable Findings

Engineered Immune Cells Can Hunt Down and Eliminate Aging Cells

Olive Oil and Margarine Beat Butter in Breakfast Battle for Reducing Inflammation: Spanish Study

Buck Institute Study Shows Low NAD+ Drives Reproductive Aging and Hinders Fertility

Scientists Engineer Immune Cells that Can Hunt Down and Eliminate Aging Cells

Urolithin A Can Revitalize Blood Stem Cells in People and Mice, Study Finds