In a human clinical trial, Yale scientists find that caloric restriction prevents thymus shrinkage and changes the inflammatory profile of fat tissue. 

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Hiroshima and Nagasaki bombing survivors exhibit accelerated immune system aging, including reduced immune cells and higher levels of reactive oxygen species (ROS) — molecules that harm cells in excess. 


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Explore a groundbreaking Japanese study that uncovers a profound connection between atomic bomb radiation and the hastened aging of the immune system. Delve into the enduring repercussions of nuclear warfare, shedding light on the lasting impact of historical events on human health.

Japanese Study Reveals: Atomic Bomb Radiation Linked to Accelerated Immune System Aging – Unveiling Nuclear War's Lingering Effects

Immunity

A study published in Nature by the University of Minnesota shows that the same lineage of mouse immune cells can continually divide over multiple lifespans.

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Model: D-gal artificially-aged mice
Dosage: 25 mg/kg intraperitoneal injections of C3G twice a week for 4 weeks

Plant Pigment Reduces Age-Related Inflammation and Boosts NAD+ 

The pigment cyanidin-3-O-glucoside (C3G) reduces inflammatory markers and boosts NAD+ in a mouse model for aging while reducing senescence in a cell model for aging. 

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(Elderberries contain abundant cyanidin-3-O-glucoside | Jaye Thompson)

Model: female C57BL/6 mice
Dose: 350 mg/kg per day of metformin in drinking water

Metformin Protects Against Reproductive Aging

Ovarian fibrosis (scarring) – a hallmark of ovarian aging – is prevented when mice are given metformin, a common anti-diabetes medication.


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Senior author, Dr. Barbara C. Vanderhyden | University of Ottawa 

Female KunMing Mice (2 months old, weight 20~25 g)
Metformin: 100 or 300 mg/kg/day for 6 weeks

Metformin Reverses Age-Related Immune System Decline 

Researchers from Zhengzhou University utilize metformin to attenuate the degeneration of the thymus - an immune organ that plays a vital role in the development and function of immune fighting cells (T cells). 


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Bracknell,,England,-,January,14,,2014:,A,Box,Of,Metformin

BALB/c (female, 8-12 weeks) mice
Free NAD+ (20 mg/kg)
NAD+-LP-CaP (20 mg/kg)

 NAD+ Nanoparticles Increase Survival from Sepsis by Over Fourfold 

University of Wisconsin researchers utilize nano-sized fat particles (lipid nanoparticles) loaded with NAD+ to increase survival, rescue immune cells, and preserve energy production. 


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Madison,,Wi,-,October,29,,2021:,University,Of,Wisconsin,Logo

Model: Aged male C57Bl/6 mice
Dosage/Administration: 1 microgram/kilogram intravenous injection S100p1-G

Scientists find a metabolite secreted by gut bacteria in aged mice that can be blocked to prevent cognitive deficits.

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Xiang Zhang PhD

Co-Author, Dr. Xiang Zhang | University of Louisville

Swedish scientists find that electrical stimulation of the vagus nerve resolves (stops/ends) inflammation by increasing specialized fatty acids derived from omega-3s in mice.  


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Bacteria from a Young Gut Reverse Age-Related Inflammation

Fecal matter transplants from young mice could positively affect inflammation in the eyes, brains, and intestines of aged mice by affecting gut microbiota composition.

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Gut bacteria from young mice has been shown to reverse age-related inflammation in mice.

Killer Immune Cells Supress the Root of Aging 

Chinese scientists find that immune cell treatment diminishes senescence — considered the root of aging — in human tissue, an effect enhanced by elevating the neurotransmitter dopamine in aged mice. 


Caloric Restriction Decreases Inflammation in Humans

Japanese Study Links Radiation with Accelerated Immune Aging: Nuclear Power’s Lasting Impact

Immune Cells Can Avoid Aging to Produce Progeny 30,000x the Earth’s Volume

Researchers find Plant Pigment that Reduces Age-Related Inflammation and Boosts NAD⁺

Anti-Diabetes Drug Metformin Protects Against Reproductive Aging in Latest Study

New Study Shows Metformin Reverses Age-Related Thymus Degeneration by Boosting Mitochondrial Function

New Study Shows NAD⁺ Nanoparticles Increase Survival from Sepsis by Over Fourfold in Mice

Researchers Find Blocking Gut Metabolite Prevents Cognitive Decline

Study from Sweden Suggests Nerve Stimulation Device Could Slow Aging

Study Shows Gut Bacteria from Young Mice Reverses Age-Related Inflammation

Dopamine Enhances Immune Cell Response Against Senescent Cells