Model: Eight-week-old male C57BL/6J mice treated with 400 mg/kg/day of D-galactose via intraperitoneal injection for 12 weeks to induce accelerated aging.
Dosage: 400 mg/kg/day of Antarctic krill oil administered by oral gavage for 12 weeks, alongside D-galactose treatment. A comparison group received 400 mg/kg/day of fish oil under the same conditions.

Krill Oil Preserves Muscle Strength and Mitochondrial Health During Accelerated Aging

Daily krill oil supplementation preserves muscle strength, endurance, and mitochondrial health in mice with accelerated aging, outperforming fish oil.

Skin &amp; Muscle

Model: Eight-week-old C57BL/6J mice treated with 300 mg/kg/day of D-galactose by subcutaneous injections for eight weeks
Dosage: 100 mg/kg/day of NMN in drinking water for eight weeks and 5 × 10 5 hUC-MSCs suspended in 150 µL of PBS via tail vein injection on the first day of weeks five through seven

NMN Enhances Stem Cell Therapy’s Effects on Immune Aging in Latest Study

Combining NMN with umbilical cord–derived stem cells improved motor and cognitive function while reducing markers of immune aging in mice with chemically induced aging.

(An image of human umbilical cord-derived mesenchymal stem cells under a microscope | NAD.com)

NMN with a stem cell therapy reduced markers of immune aging and improved coordination and memory performance in mice with chemically induced aging-like changes.

Immunity

Model: Young acquired niacin dependency (ANDY) mice. 
Dosage: 30 mg/kg/day of niacin

Mice engineered to have low body-wide NAD+ levels exhibit a shortened lifespan and widespread physical decline, which is largely reversed with the NAD+ booster niacin. 

NAD+ (nicotinamide adenine dinucleotide) levels were lower among older adults with frailty—an age-related condition associated with increased vulnerability to disability, disease, and death.

Model: Chronically stressed mice 
Dosage: 9 mg/kg/day of L-serine, or 5 mg/kg/day of dasatinib combined with 50 mg/kg/day of quercetin

Supplementing chronically stressed mice with L-serine, an amino acid, counters signs of anxiety and diabetes while diverting age-promoting senescent cells within the brain’s fear center. 

Search Result: stress

Krill Oil Preserves Muscle Strength and Mitochondrial Health During Accelerated Aging

NMN Enhances Stem Cell Therapy’s Effects on Immune Aging in Latest Study

New Mayo Clinic Study: Forcibly Depleting NAD+ Shortens Lifespan

NAD+ Levels are Low Among Individuals with Frailty, New Japanese Study Shows

Cheap Supplement May Counter Stress-Induced Diabetes, Anxiety, and Brain Senescence, According to New Study