<p><span style="font-weight: 400;">Model: Female Balb/c mice exposed to ultraviolet radiation </span></p>
<p><span style="font-weight: 400;">Dosage: 2%, 5%, 7.5%, or 12.5% of nicotinamide (weigh</span><i><span style="font-weight: 400;">t</span></i><span style="font-weight: 400;">/volume) applied topically, once daily, five times per week </span></p>


The NAD+ (nicotinamide adenine dinucleotide) precursor nicotinamide prevents skin aging, in part by targeting age-promoting senescent cells in mice. 


New Framework Uncovers 21 Existing Drugs with Pro-Longevity Potential

A new gene network-based framework predicts the potential of existing drugs to confer pro-longevity effects.

A new gene network-based framework predicts already-approved repurposable drugs that may either confer pro-longevity benefits or age-accelerating effects.

Aging &amp; Longevity

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<p class="PDq2pG_selectionAnchorContainer" data-start="0" data-end="125">Model: 4-week-old <span class="hover:entity-accent entity-underline inline cursor-pointer align-baseline"><span class="whitespace-normal">SM/J</span></span> mice (with <span class="hover:entity-accent entity-underline inline cursor-pointer align-baseline"><span class="whitespace-normal">C57BL/6J</span></span> comparison mice)</p>
<p data-start="127" data-end="279" data-is-last-node="" data-is-only-node="">Dosage: Weekly intraperitoneal injections of 40 mg/kg Navitoclax or 5 mg/kg Dasatinib + 50 mg/kg Quercetin from 4 to 6–8 or 17 weeks of age.</p>
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Dasatinib and Quercetin Delay Early-Onset Disc Degeneration in Mice

Researchers find that clearing senescent cells preserves disc structure and slows early-onset disc degeneration in mice.


Top Evidence-Based Interventions to Lower Biological Age

Epigenetic aging clocks estimate biological age based on DNA molecular tagging patterns, and interventions like semaglutide and ketamine reduce these estimates in humans.

(The principal investigator behind the review on interventions that influence biological age, Dr. David Sinclair | The Society of the Four Arts)

As reviewed in this article, epigenetic aging clocks have estimated the effects of pharmaceutical interventions, lifestyle habits, supplements, and clinical interventions on biological age.

<p><span style="font-weight: 400;">Participants: Healthy, overweight older adults </span></p>
<p><span style="font-weight: 400;">Dosage: 6 mg/day of spermidine supplemented orally for 13 weeks </span></p>


Oxford scientists find that spermidine, a naturally occurring molecule that declines with age, rejuvenates aging immune cells and improves vaccine protection in older adults. 


Study conducted at the University of Oxford in England. 

Search Result: senescent cells

NAD+ Booster Nicotinamide Counters Skin Aging and Cell Senescence, New Study Shows

New Framework Uncovers 21 Existing Drugs with Pro-Longevity Potential

Dasatinib and Quercetin Delay Early-Onset Disc Degeneration in Mice

Top Evidence-Based Interventions to Lower Biological Age

Anti-Aging Spermidine Boosts Immune System, New Study Shows