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<p class="PDq2pG_selectionAnchorContainer" data-start="0" data-end="125">Model: 4-week-old <span class="hover:entity-accent entity-underline inline cursor-pointer align-baseline"><span class="whitespace-normal">SM/J</span></span> mice (with <span class="hover:entity-accent entity-underline inline cursor-pointer align-baseline"><span class="whitespace-normal">C57BL/6J</span></span> comparison mice)</p>
<p data-start="127" data-end="279" data-is-last-node="" data-is-only-node="">Dosage: Weekly intraperitoneal injections of 40 mg/kg Navitoclax or 5 mg/kg Dasatinib + 50 mg/kg Quercetin from 4 to 6–8 or 17 weeks of age.</p>
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Dasatinib and Quercetin Delay Early-Onset Disc Degeneration in Mice

Researchers find that clearing senescent cells preserves disc structure and slows early-onset disc degeneration in mice.


Aging &amp; Longevity

<p><strong data-start="26" data-end="36">Model:</strong> Older adults (60–85 years old) with mild cognitive impairment (MCI) enrolled in a randomized, double-blind, placebo-controlled clinical trial.</p>
<p><strong data-start="222" data-end="233">Dosage:</strong> Participants received one gastro-resistant capsule daily for 180 days, containing either 250 mg of <em data-start="339" data-end="363">Kluyveromyces fragilis</em> yeast extract, 350 mg of <em data-start="393" data-end="419">Saccharomyces cerevisiae</em> yeast extract, or a placebo.</p>


Yeast Supplement Improves Cognitive Function in Older Adults with Mild Cognitive Impairment

Daily supplementation with nucleotide-rich yeast extracts improves cognitive performance and mental well-being in older adults with mild cognitive impairment, researchers find. 

Brain &amp; Neurons

The NAD+ (nicotinamide adenine dinucleotide) precursor NR (nicotinamide riboside) counters sleep-deprivation-induced cognitive deficits in rats with excess Alzheimer’s plaques. 


GlyNAC and Exercise for Age-Related Muscle Loss: Mechanisms and Clinical Evidence

Human trials report that GlyNAC and exercise regimens improve dysfunction of the cell’s powerhouses (mitochondria), inflammation, muscle strength, and cognition.

(Some GlyNAC tablets above the chemical structure of GlyNAC | Vitamin Retailer)

GlyNAC supplementation and exercise alleviate mitochondrial dysfunction, lower inflammation, increase muscle strength, and bolster cognition.

Skin &amp; Muscle

<p><span style="font-weight: 400;">Model: Old male mice</span></p>
<p><span style="font-weight: 400;">Dosage: 100 mg/kg/day of ALA administered in drinking water </span></p>


Restoring the naturally occurring antioxidant, alpha-lipoic acid (ALA), to the gut wall rejuvenates stem cells and counters age-related gut degeneration in mice and human models. 

Images of miniature intestines developed from intestinal stem cells. 

Search Result: recent study

Dasatinib and Quercetin Delay Early-Onset Disc Degeneration in Mice

Yeast Supplement Improves Cognitive Function in Older Adults with Mild Cognitive Impairment

NAD+ Booster Counters Cognitive Deficits of Sleep Deprivation, New Study Shows

GlyNAC and Exercise for Age-Related Muscle Loss: Mechanisms and Clinical Evidence

Alpha-Lipoic Acid Rejuvenates Stem Cells & Improves Gut, New Study Shows