Participants: Prefrail older adults
Dosage: 50 mg/day of losartan for at least 8 weeks

Losartan, a common blood pressure medication, increases the survival rate of mice and improves the metabolic outlook of pre-frail older adults. 

Principal Investigator of the study, Dr. Peter M. Abadir (image: jhu.edu).

Aging &amp; Longevity

Model: C57BL/6 mice
Dosage: 500 mg/kg/day of SRN-901 via oral gavage for six days per week starting at 18 months of age; 14.4 ppm of rapamycin mixed in food starting at 18 months of age; 300 mg/kg/day of NMN via oral gavage for six days per week starting at 18 months of age; and 300 mg/kg/day of NR via oral gavage for six days per week starting at 18 months of age

Seragon Publishes Record-Breaking SRN-901 Longevity Data, Demonstrating 33% Lifespan Extension in Mice

In a newly published mouse study, SRN-901 extended remaining lifespan by 33%, slowed frailty progression, and lowered tumor incidence.

Seragon’s SRN-901 extended the remaining lifespan of adult mice by 33%, attenuated frailty progression by 70%, and reduced tumor incidence by 30.53%, according to a newly published preclinical study.

Participants: Healthy adults 
Dosage: An escalating dose of niacin (250-1000 mg/day) for 16 weeks

Finnish scientists used a new measurement system to detect low NAD+ levels in blood samples from people with a range of age-related conditions, but not in healthy older individuals.


Principal Investigator of the study, Dr. Anu Suomalainen (image: helenski.fi).

Andrew Huberman’s Updated Supplement Stack for 2026

Stanford neuroscientist Andrew Huberman’s updated supplement list includes the NAD+ precursor NMN, along with other compounds for sleep and cognitive performance.

Dr. Andrew Huberman’s new supplement stack for 2026 includes NMN, along with supplements supporting sleep, testosterone synthesis, and cognitive function.

Model: 11-month-old male C57BL/6J mice 
Dosage: 30 mg/kg/day of NTX-748 (based on a small molecule called 78c) for 4 months, administered orally

Blocking NAD+ Breakdown Improves Cognitive and Physical Performance

Buck Institute scientists find that blocking the CD38 enzyme, which elevates NAD+ (nicotinamide adenine dinucleotide), counteracts age-related cognitive and physical decline in mice.  

Study conducted at the Buck Institute for Research on Aging (image: linkedin.com).

Search Result: physical activity

New Johns Hopkins Study: FDA-Approved Losartan May Extend Lifespan

Seragon Publishes Record-Breaking SRN-901 Longevity Data, Demonstrating 33% Lifespan Extension in Mice

NAD+ Levels in Healthy Aging: New Study Reveals Surprising Trends

Andrew Huberman’s Updated Supplement Stack for 2026

Blocking NAD+ Breakdown Improves Cognitive and Physical Performance: New Study