Model: Chronically stressed mice 
Dosage: 9 mg/kg/day of L-serine, or 5 mg/kg/day of dasatinib combined with 50 mg/kg/day of quercetin

Supplementing chronically stressed mice with L-serine, an amino acid, counters signs of anxiety and diabetes while diverting age-promoting senescent cells within the brain’s fear center. 

Diabetes &amp; Obesity

Model: SAMP8 mice (5 months old) and C57BL/6 mice (16 months old)
Dosage: 1.5 mg/kg of urolithin A was administered by intraperitoneal injection three times per week (Monday, Wednesday, and Friday) for 8 weeks.

Study shows that urolithin A preserves memory and cognitive function during aging when treatment begins before age-related decline, but does not reverse cognitive impairment once it is established.

Brain &amp; Neurons

Model: Old (17- to 19-month-old) C57BL6 mice 
Dosage: 14 mg/mg/day of rapamycin in food for 5 months

A purported longevity drug, rapamycin, alters immune cells associated with cancer and reduces brain inflammation in mice. 

Immunity

Participants: Healthy middle-aged adults 
Dosage: 1200 mg/day of NR for 4 weeks

NR Raises NAD+ 2-Fold More than NMN

NR (nicotinamide riboside) raises blood NAD+ (nicotinamide adenine dinucleotide) levels more than NMN (nicotinamide mononucleotide) in healthy adults. 

Some of the researchers on the study, Dr. Christian Dölle (left) and Dr. Charalampos Tzoulis (middle) from the University of Bergen in Norway (image: uib.no). 

Model: Naturally aged 24-month-old C57BL/6 mice 
Dose: 0.1 mg/kg/day of folic acid administered orally for 12 months

Supplementation with vitamin B9, also known as folic acid or folate, prevents cellular senescence and slows vascular aging in naturally aged mice.  

Search Result: neurological

Cheap Supplement May Counter Stress-Induced Diabetes, Anxiety, and Brain Senescence, According to New Study

Urolithin A Preserves Memory During Aging When Treatment Begins Early, Study Shows

Rapamycin Elevates Immune Cells That Can Battle Cancer Cells, New Study Shows

NR Raises NAD+ Over 2-Fold More than NMN: New Study Comparing NAD+ Precursors

New Study: Vitamin B9 Combats Cell Senescence to Slow Vascular Aging