Model: Eight-week-old C57BL/6J mice treated with 300 mg/kg/day of D-galactose by subcutaneous injections for eight weeks
Dosage: 100 mg/kg/day of NMN in drinking water for eight weeks and 5 × 10 5 hUC-MSCs suspended in 150 µL of PBS via tail vein injection on the first day of weeks five through seven

NMN Enhances Stem Cell Therapy’s Effects on Immune Aging in Latest Study

Combining NMN with umbilical cord–derived stem cells improved motor and cognitive function while reducing markers of immune aging in mice with chemically induced aging.

(An image of human umbilical cord-derived mesenchymal stem cells under a microscope | NAD.com)

NMN with a stem cell therapy reduced markers of immune aging and improved coordination and memory performance in mice with chemically induced aging-like changes.

Immunity

Model: Apoe−/− C57BL/6J mice fed a high-fat diet
Dosage: 1 × 109 CFU per 0.1 mL of Bacteroides uniformis administered to mice via oral gavage for 12 weeks and 25 mg/kg of pentadecanoic acid via oral gavage three times per week for eight weeks

New Study: Gut Bacteria Metabolite Reduces Arterial Plaque Burden by 50%

Researchers identified pentadecanoic acid, a gut-bacteria-produced metabolite, that lowered LDL cholesterol and limited arterial plaque buildup in mice.

(A depiction of various gut bacteria in the intestines | NAD.com)

A gut bacterial metabolite reduced arterial plaque buildup by about 50% in mice, revealing a potential link between gut microbes and cholesterol regulation.

Cardiovascular

Model: 6-week-old ICR mice
Dosage: 250 mg/kg per day or 500 mg/kg per day of glucosamine and 100 mg/kg per day or 200 mg/kg per day of aspirin for either eight (acute alcohol exposure model) or 40 days (chronic alcohol exposure model)

New Study Supports Repurposing Glucosamine Against Liver Aging

A sugar-like compound found in cartilage called glucosamine reduces dysfunctional cells (senescent cells) in the liver and attenuates liver damage from alcohol consumption in mice.

(Glucosamine capsules | MedicalNewsToday)

Glucosamine alleviates liver damage from alcohol consumption in mice, supporting its potential for use against alcoholic liver disease.

Aging &amp; Longevity

Model: Male C57BL/6J (B6) mice (15 months old at the start of treatment)
Dosage: Approximately 5 mg/kg/day of S-1-propenyl-L-cysteine (S1PC) was administered orally for 8 months, from 15 to 23 months of age. S1PC was given in chow containing 0.0025% S1PC, with a second experiment using drinking water to confirm the findings.

Researchers found that a compound found in garlic supports healthier muscle aging by boosting cellular defenses linked to longevity and maintaining physical performance.

Skin &amp; Muscle

Model: SAMP8 mice (5 months old) and C57BL/6 mice (16 months old)
Dosage: 1.5 mg/kg of urolithin A was administered by intraperitoneal injection three times per week (Monday, Wednesday, and Friday) for 8 weeks.

Study shows that urolithin A preserves memory and cognitive function during aging when treatment begins before age-related decline, but does not reverse cognitive impairment once it is established.

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NMN Enhances Stem Cell Therapy’s Effects on Immune Aging in Latest Study

New Study: Gut Bacteria Metabolite Reduces Arterial Plaque Burden by 50%

New Study Supports Repurposing Glucosamine Against Liver Aging and Alcoholic Liver Disease

Garlic-Derived Compound Activates a Natural Anti-Aging Pathway That Preserves Muscle Function

Urolithin A Preserves Memory During Aging When Treatment Begins Early, Study Shows