Longevity Fanatic Bryan Johnson’s Daily Aging Intervention Routine for 2025

Aging guru Bryan Johnson shares his latest daily longevity protocol, which he uses to optimize measurements of his body’s aging.

(A futuristic image of Bryan Johnson | YouTube)

Venture capitalist and aging guru Bryan Johnson reveals his latest longevity-focused daily routine for 2025, focusing on sleep, exercise, and eating well.

Aging &amp; Longevity

Model: 10-month-old and 22-month-old naturally aged mice / Rats with Partial Discectomy (PDE)-induced Temporomandibular Joint Osteoarthritis (TMJOA).
Dosage: 0.25% αKG and  0.75% αKG
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Longevity Compound Thwarts Age-Related Joint Degeneration: New Study Reveals

Researchers found that alpha-ketoglutarate (αKG) can treat osteoarthritis by preserving cartilage and reducing joint inflammation. 

Skin &amp; Muscle

Dr. Sinclair and collaborators show that an age-reversal technology that rejuvenates cells protects neurons from inflammation and cell death in mice. 

Brain &amp; Neurons

A molecule known as miR-302b prolongs the life of mice by “waking up” senescent cells — “sleeping” cells that contribute to life-shortening chronic diseases. 

Depiction of microRNA molecules (Image: Artur Plawgo/iStock Photo/MIT.edu). 

Model: 9-month-old male rats 
Dosage: 20 mg/kg of ergothioneine for three weeks

Ergothioneine — a naturally occurring compound found in mushrooms — increases the muscle size of middle-aged rats while extending the lifespan of worms. 


First author of the study, Dunja Petrovic (Image: isas.de)

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Longevity Fanatic Bryan Johnson’s Daily Aging Intervention Routine for 2025

Longevity Compound Thwarts Age-Related Joint Degeneration: New Study Reveals

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