Model: Female Balb/c mice exposed to ultraviolet radiation 
Dosage: 2%, 5%, 7.5%, or 12.5% of nicotinamide (weight/volume) applied topically, once daily, five times per week

The NAD+ (nicotinamide adenine dinucleotide) precursor nicotinamide prevents skin aging, in part by targeting age-promoting senescent cells in mice. 


Model: Male Wistar rats 
Dosage: 1.5 g/kg/day of orally administered glycine for 5 months

Glycine, an amino acid shown to extend the lifespan of mice, moderately extends the lifespan of flies and counters brain and muscle degeneration in aged rats. 

Aging &amp; Longevity

Model: C57BL/6J mice 
Dosage: Eating only within an 8-hour window and fasting for 16 hours (~20% caloric deficit may be required)

Restricting food intake for 16 hours a day improves the health of female mice and moderately prolongs the life of male mice. 

The principal investigators of the study (from left to right): Dr. Carla Green, Dr. Victoria Acosta-Rodriguez, and Dr. Joseph Takahashi (image: dallasnews.com). 

Model: SAMP8 mice 
Dosage: ~25 mg/kg/day of PQQ or PQI administered in food

Supplementing with the antioxidant pyrroloquinoline quinone (PQQ) modestly extends the lifespan of age-accelerated mice while improving their strength.  


GlyNAC and Exercise for Age-Related Muscle Loss: Mechanisms and Clinical Evidence

Human trials report that GlyNAC and exercise regimens improve dysfunction of the cell’s powerhouses (mitochondria), inflammation, muscle strength, and cognition.

(Some GlyNAC tablets above the chemical structure of GlyNAC | Vitamin Retailer)

GlyNAC supplementation and exercise alleviate mitochondrial dysfunction, lower inflammation, increase muscle strength, and bolster cognition.

Search Result: muscle aging

NAD+ Booster Nicotinamide Counters Skin Aging and Cell Senescence, New Study Shows

Glycine Extends Life & Counters Brain and Muscle Degeneration, New Study Shows

16-Hour Intermittent Fasting Improves Health and Longevity, New Study Confirms

Powerful Antioxidant PQQ Extends Life and Improves Strength, New Study Shows

GlyNAC and Exercise for Age-Related Muscle Loss: Mechanisms and Clinical Evidence