University of Southern California (USC) scientists help to uncover why human intelligence declines with age, pointing to a newly discovered cellular target.


The principal investigator on the study, Dr. Michael Bonaguidi (image: usc.edu).

Brain &amp; Neurons

Model: 20-month-old female C57BL/J mice 
Dosage: 10 nmol/kg/day of semaglutide

Semaglutide extends mouse lifespan and targets signs of aging, such as diminished NAD+, while mimicking the anti-aging effects of caloric restriction (consuming fewer calories). 


The study was led by Dr. Danica Chen (image: berkeley.edu). 

Aging &amp; Longevity

Model: SAMP8 mice (5 months old) and C57BL/6 mice (16 months old)
Dosage: 1.5 mg/kg of urolithin A was administered by intraperitoneal injection three times per week (Monday, Wednesday, and Friday) for 8 weeks.

Study shows that urolithin A preserves memory and cognitive function during aging when treatment begins before age-related decline, but does not reverse cognitive impairment once it is established.

Repurposing Erectile Dysfunction Pills for Longevity

Some people are taking erectile dysfunction medications like Cialis and Viagra for more than sex—rather, to help them live longer.

(Tablets of the erectile dysfunction drugs Cialis and Viagra | Prostate Prognosis)

People have started repurposing erectile dysfunction medications, such as Cialis and Viagra, to help them live longer.

Model: Female Balb/c mice exposed to ultraviolet radiation 
Dosage: 2%, 5%, 7.5%, or 12.5% of nicotinamide (weight/volume) applied topically, once daily, five times per week

The NAD+ (nicotinamide adenine dinucleotide) precursor nicotinamide prevents skin aging, in part by targeting age-promoting senescent cells in mice. 


Search Result: memory loss

Beyond Neurons: New Study Pinpoints Immature Brain Cells Behind Age-Related Drops in Intelligence

Semaglutide (Ozempic) Prolongs Lifespan & Boosts NAD+ in Mice, New Study Shows

Urolithin A Preserves Memory During Aging When Treatment Begins Early, Study Shows

Repurposing Erectile Dysfunction Pills for Longevity

NAD+ Booster Nicotinamide Counters Skin Aging and Cell Senescence, New Study Shows