Model: Aged mice (18 months old) underwent exploratory laparotomy under isoflurane anesthesia to induce POCD.
Dosage: Berberine was given by oral gavage at 100 mg/kg per day for 14 days after surgery.

Ancient Plant Compound Shows Promise for Protecting the Aging Brain 

Study shows berberine, a natural plant compound, protects memory in aging mice after surgery by reducing brain inflammation, stress, and cell damage.


Brain &amp; Neurons

Chinese scientists have genetically engineered stem cells capable of rejuvenating the health, including the cognition, of aged macaques. 

A young crab-eating macaque (image: shutterstock.com). 

Aging &amp; Longevity

Cutting-edge technology has allowed scientists to examine young and old brains with single-cell resolution, gaining insights into how we can rejuvenate our brain cells to stay sharp. 


Stanford University scientist and corresponding author on the new study, Dr. Anne Brunet (image: labxchange.org). 

Model: C57BL/6J mice, J20 mice, and 3xTg mice 
Dosage: 4.3 μEq l−1 of lithium in drinking water starting at 10 to 12 months of age and continued for 10 to 14 months during aging

Harvard Study: A Low Dose of Lithium May Preserve Cognitive Resilience with Age

Researchers uncover significantly lower brain lithium levels in Alzheimer’s disease patients, and supplementing with a low-dose lithium salt restores memory in an Alzheimer’s disease mouse model.

(The study’s principal investigator, Bruce Yankner [center], with four laboratory employees | The Boston Globe)

A Harvard study suggests lower levels of lithium in the brains of patients with Alzheimer’s disease and that lithium supplementation may help preserve cognitive resilience.

A vaccine targeting an enzyme that breaks down NAD+, called CD38, counteracts signs of aging in mice. 


Search Result: memory loss

Ancient Plant Compound Shows Promise for Protecting the Aging Brain

Anti-Aging Breakthrough: Stem Cells Reverse Signs of Aging in Monkeys

Brain Aging Interventions: Key Insights from a New Stanford Study

Harvard Study: A Low Dose of Lithium May Preserve Cognitive Resilience with Age

Anti-Aging Vaccine Boosts Strength, Memory & NAD+ in New Study