Model: Male COX7RP transgenic mice with systemic overexpression of COX7RP, aged under standard laboratory conditions and compared with age-matched wild-type controls.
Dosage: Not applicable. COX7RP activity was increased via genetic overexpression rather than drug administration.

Boosting mitochondrial efficiency by increasing COX7RP activity extended lifespan in mice while improving energy production and reducing inflammation.

Aging &amp; Longevity

How to Boost Mitochondrial Density and Quality for Longevity

Lifestyle hacks contrived to promote the tissue density and quality of mitochondria (the cell’s powerhouses) can aid in the efficient generation of cellular energy and reduce inflammation, thereby promoting longevity.

(A colorized image of mitochondria taken with a transmission electron microscope | UC San Diego Today)

Exercise, nutritional support, and lifestyle hacks like cold exposure can all help mitigate mitochondrial dysfunction, a key hallmark of aging.

New Study Shows Cranberry Extract Equivalent to Metformin in Fighting Aging

Fayoum University researchers found that cranberry polyphenols improve metabolic markers, cognition, and oxidative stress to the same degree as the drug metformin.

A new study suggests cranberry extract has effects against aging that rival metformin.

Model: 20-month-old male C57BL/6 mice 
Dosage: 3,000 to 4,000 µg of ouabain dissolved in 27,000 to 36,000 µL of PBS injected twice per week every third week over a period of three months

AI Analyzes Millions of Molecular Profiles to Uncover Overlooked Aging Interventions

Harvard and MIT scientists analyze decades of publicly available molecular studies with a new AI platform to uncover hundreds of previously hidden anti-aging strategies, like the drug ouabain.

A new AI platform has uncovered hundreds of pro-longevity agents based on the reanalysis of millions of mouse and human gene expression samples.

Innovative Computer Model Reveals Aging May Stem from Lost Cellular Purpose

A new computer simulation suggests aging occurs when cells and tissues lose their developmental goals, offering a fresh perspective on rejuvenation strategies.

(The article’s principal investigator, Michael Levin | Tufts Now)

An innovative computer model simulates aging, suggesting that cells and tissues lose their developmental goals, leading to physiological deterioration.

Search Result: longevity genes

New Study Shows Increasing Mitochondrial Protein Improves Energy Production and Extends Lifespan

How to Boost Mitochondrial Density and Quality for Longevity

New Study Shows Cranberry Extract Equivalent to Metformin in Fighting Aging

AI Analyzes Millions of Molecular Profiles to Uncover Overlooked Aging Interventions

Innovative Computer Model Reveals Aging May Stem from Lost Cellular Purpose