The Future of Longevity: Could Humans Really Live to 150?

A TIME Magazine longevity panel, featuring Harvard’s David Sinclair, explores whether breakthroughs in AI, cellular rejuvenation, and research on sex differences could help today’s children live far longer.

(An image illustrating the possibility of some humans achieving a 150-year lifespan in the future | NAD.com)

David Sinclair and Jennifer Garrison discuss whether AI advancements, cellular rejuvenation techniques, and research on sex differences can make a 150-year lifespan possible.

Aging &amp; Longevity

The Harvard geneticist discussed an early human trial, unpublished mouse results, and an AI-assisted search for chemical rejuvenation therapies on the Joe Rogan Experience. 

Model: 20-month-old female C57BL/J mice 
Dosage: 10 nmol/kg/day of semaglutide

Semaglutide extends mouse lifespan and targets signs of aging, such as diminished NAD+, while mimicking the anti-aging effects of caloric restriction (consuming fewer calories). 


The study was led by Dr. Danica Chen (image: berkeley.edu). 

Scientists find that meloxicam preserves muscle mass and strength in aged mice while sustaining mitochondrial function and activating multiple molecules associated with longevity. 


Skin &amp; Muscle

Model: Old (17- to 19-month-old) C57BL6 mice 
Dosage: 14 mg/mg/day of rapamycin in food for 5 months

A purported longevity drug, rapamycin, alters immune cells associated with cancer and reduces brain inflammation in mice. 

Search Result: longevity genes

The Future of Longevity: Could Humans Really Live to 150?

Self-Proclaimed “Prophet of Longevity” David Sinclair Reveals New Anti-Aging Data

Semaglutide (Ozempic) Prolongs Lifespan & Boosts NAD+ in Mice, New Study Shows

Repurposed Arthritis Drug Counters Muscle Mass Loss with Age, New Study Shows

Rapamycin Elevates Immune Cells That Can Battle Cancer Cells, New Study Shows