Model: 20-month-old female C57BL/J mice 
Dosage: 10 nmol/kg/day of semaglutide

Semaglutide extends mouse lifespan and targets signs of aging, such as diminished NAD+, while mimicking the anti-aging effects of caloric restriction (consuming fewer calories). 


The study was led by Dr. Danica Chen (image: berkeley.edu). 

Aging &amp; Longevity

Model: SAMP8 mice (5 months old) and C57BL/6 mice (16 months old)
Dosage: 1.5 mg/kg of urolithin A was administered by intraperitoneal injection three times per week (Monday, Wednesday, and Friday) for 8 weeks.

Study shows that urolithin A preserves memory and cognitive function during aging when treatment begins before age-related decline, but does not reverse cognitive impairment once it is established.

Brain &amp; Neurons

Examining Evidence for the Cognition-Enhancing Potential of the Antioxidant Astaxanthin

The antioxidant astaxanthin significantly extends male mouse lifespan, and human research suggests it may help prevent age-related cognitive decline.

(An image of the red-orange pigment astaxanthin | Gruppo Farmalmpresa)

The potent antioxidant astaxanthin may have pro-longevity effects, and human trial data suggests it improves cognitive function in older adults.

Model: Older adults (60–85 years old) with mild cognitive impairment (MCI) enrolled in a randomized, double-blind, placebo-controlled clinical trial.
Dosage: Participants received one gastro-resistant capsule daily for 180 days, containing either 250 mg of Kluyveromyces fragilis yeast extract, 350 mg of Saccharomyces cerevisiae yeast extract, or a placebo.

Yeast Supplement Improves Cognitive Function in Older Adults with Mild Cognitive Impairment

Daily supplementation with nucleotide-rich yeast extracts improves cognitive performance and mental well-being in older adults with mild cognitive impairment, researchers find. 

Model: 5xFAD mouse model for Alzheimer’s disease 
Dosage: Oral administration of 457 mg/kg/day of glucosamine for 2 weeks

Supplementing with glucosamine, a compound found in our cartilage, increases the risk of mortality from dementia in certain individuals while also worsening memory in mice that model dementia. 

Study led by Dr. Ramon Sun on the far right (image: mbi.ufl.edu). 

Search Result: learning

Semaglutide (Ozempic) Prolongs Lifespan & Boosts NAD+ in Mice, New Study Shows

Urolithin A Preserves Memory During Aging When Treatment Begins Early, Study Shows

Examining Evidence for the Cognition-Enhancing Potential of the Antioxidant Astaxanthin

Yeast Supplement Improves Cognitive Function in Older Adults with Mild Cognitive Impairment

Common Joint Health Supplement May Progress Dementia, New Study Finds