Model: 6-week-old ICR mice
Dosage: 250 mg/kg per day or 500 mg/kg per day of glucosamine and 100 mg/kg per day or 200 mg/kg per day of aspirin for either eight (acute alcohol exposure model) or 40 days (chronic alcohol exposure model)

New Study Supports Repurposing Glucosamine Against Liver Aging

A sugar-like compound found in cartilage called glucosamine reduces dysfunctional cells (senescent cells) in the liver and attenuates liver damage from alcohol consumption in mice.

(Glucosamine capsules | MedicalNewsToday)

Glucosamine alleviates liver damage from alcohol consumption in mice, supporting its potential for use against alcoholic liver disease.

Aging &amp; Longevity

Finalist Teams Awarded $1 Million in XPrize Healthspan Contest to Transform Healthy Aging

The XPrize Healthspan—which will split $101 million among teams developing therapeutics to restore muscle, cognitive, and immune function in older adults—has named 10 teams receiving $1 million each.

(XPrize announced the finalists for its XPrize Healthspan competition | XPrize)

The XPrize Healthspan competition has named its top 20 finalist groups that will submit their aging intervention therapies for human trial testing.

The Overlooked Organ That Could Hold the Key to Fighting Aging

Scientists are researching ways to regrow the thymus, an immune organ that vanishes with age, to suppress the tolls of aging.

(The thymus [colored orange] is located in the upper chest | NAD.com)

An organ involved in immunity, the thymus, vanishes as people get older, and scientists are researching ways to regrow it to fight aging.

Immunity

Model: Old (17- to 19-month-old) C57BL6 mice 
Dosage: 14 mg/mg/day of rapamycin in food for 5 months

A purported longevity drug, rapamycin, alters immune cells associated with cancer and reduces brain inflammation in mice. 

Model: Female Balb/c mice exposed to ultraviolet radiation 
Dosage: 2%, 5%, 7.5%, or 12.5% of nicotinamide (weight/volume) applied topically, once daily, five times per week

The NAD+ (nicotinamide adenine dinucleotide) precursor nicotinamide prevents skin aging, in part by targeting age-promoting senescent cells in mice. 


Search Result: immune system

New Study Supports Repurposing Glucosamine Against Liver Aging and Alcoholic Liver Disease

10 Finalist Teams Awarded $1 Million in XPrize Healthspan Contest to Transform Healthy Aging

The Overlooked Organ That Could Hold the Key to Fighting Aging

Rapamycin Elevates Immune Cells That Can Battle Cancer Cells, New Study Shows

NAD+ Booster Nicotinamide Counters Skin Aging and Cell Senescence, New Study Shows