Model: Apoe−/− C57BL/6J mice fed a high-fat diet
Dosage: 1 × 109 CFU per 0.1 mL of Bacteroides uniformis administered to mice via oral gavage for 12 weeks and 25 mg/kg of pentadecanoic acid via oral gavage three times per week for eight weeks

New Study: Gut Bacteria Metabolite Reduces Arterial Plaque Burden by 50%

Researchers identified pentadecanoic acid, a gut-bacteria-produced metabolite, that lowered LDL cholesterol and limited arterial plaque buildup in mice.

(A depiction of various gut bacteria in the intestines | NAD.com)

A gut bacterial metabolite reduced arterial plaque buildup by about 50% in mice, revealing a potential link between gut microbes and cholesterol regulation.

Cardiovascular

Protein Restriction and Longevity: Can Limiting Protein Intake Support Healthy Aging?

University of Wisconsin researchers examine how reducing dietary protein intake may reshape nutrient sensing, metabolism, mitochondrial function, and other pathways linked to healthier aging.

(One of the leading authors on the Cell Press Blue article, Dr. Dudley Lamming | University of Wisconsin)

Researchers examine how restricting protein intake can improve metabolic health and influence aging-related pathways to extend healthspan and lifespan.

Aging &amp; Longevity

Model: 6- to 8-week-old male C57BL/6J mice
Dosage: 0.5 mg/kg of isolated mitochondria injected every two days for six injections in the tail vein

Mitochondrial Transplantation Rejuvenates Aging Hearts, Study Finds

Transplantation of the cell’s powerhouses (mitochondria) improves heart function by restoring mitophagy (the cellular process that clears damaged mitochondria) in a mouse model of cardiac aging.

(An image depicting mitochondria [ovoid structures] in cardiac tissue | NAD.com)

Mitochondrial transplantation improves heart function by restoring the cellular process that clears damaged mitochondria in a mouse model of cardiac aging.

The Future of Longevity: Could Humans Really Live to 150?

A TIME Magazine longevity panel, featuring Harvard’s David Sinclair, explores whether breakthroughs in AI, cellular rejuvenation, and research on sex differences could help today’s children live far longer.

(An image illustrating the possibility of some humans achieving a 150-year lifespan in the future | NAD.com)

David Sinclair and Jennifer Garrison discuss whether AI advancements, cellular rejuvenation techniques, and research on sex differences can make a 150-year lifespan possible.

Repurposing Erectile Dysfunction Pills for Longevity

Some people are taking erectile dysfunction medications like Cialis and Viagra for more than sex—rather, to help them live longer.

(Tablets of the erectile dysfunction drugs Cialis and Viagra | Prostate Prognosis)

People have started repurposing erectile dysfunction medications, such as Cialis and Viagra, to help them live longer.

Search Result: heart disease

New Study: Gut Bacteria Metabolite Reduces Arterial Plaque Burden by 50%

Protein Restriction and Longevity: Can Limiting Protein Intake Support Healthy Aging?

Mitochondrial Transplantation Rejuvenates Aging Hearts, Study Finds

The Future of Longevity: Could Humans Really Live to 150?

Repurposing Erectile Dysfunction Pills for Longevity