NAD+ (nicotinamide adenine dinucleotide) levels were lower among older adults with frailty—an age-related condition associated with increased vulnerability to disability, disease, and death.

Skin &amp; Muscle

Scientists find that meloxicam preserves muscle mass and strength in aged mice while sustaining mitochondrial function and activating multiple molecules associated with longevity. 


Model: Male C57BL/6J (B6) mice (15 months old at the start of treatment)
Dosage: Approximately 5 mg/kg/day of S-1-propenyl-L-cysteine (S1PC) was administered orally for 8 months, from 15 to 23 months of age. S1PC was given in chow containing 0.0025% S1PC, with a second experiment using drinking water to confirm the findings.

Researchers found that a compound found in garlic supports healthier muscle aging by boosting cellular defenses linked to longevity and maintaining physical performance.

Model: Male Wistar rats 
Dosage: 1.5 g/kg/day of orally administered glycine for 5 months

Glycine, an amino acid shown to extend the lifespan of mice, moderately extends the lifespan of flies and counters brain and muscle degeneration in aged rats. 

Aging &amp; Longevity

Participants: Prefrail older adults
Dosage: 50 mg/day of losartan for at least 8 weeks

Losartan, a common blood pressure medication, increases the survival rate of mice and improves the metabolic outlook of pre-frail older adults. 

Principal Investigator of the study, Dr. Peter M. Abadir (image: jhu.edu).

Search Result: grip strength

NAD+ Levels are Low Among Individuals with Frailty, New Japanese Study Shows

Repurposed Arthritis Drug Counters Muscle Mass Loss with Age, New Study Shows

Garlic-Derived Compound Activates a Natural Anti-Aging Pathway That Preserves Muscle Function

Glycine Extends Life & Counters Brain and Muscle Degeneration, New Study Shows

New Johns Hopkins Study: FDA-Approved Losartan May Extend Lifespan