Elevating the naturally occurring molecule NAD+ (nicotinamide adenine dinucleotide) improves memory and corrects gene-splicing patterns in a worm and a mouse model for dementia. 

Senior author on the study, Dr. Evandro Fang (front left), with some students (image: evandrofanglab.com)

Brain &amp; Neurons

Participants: Adults over the age of 60
Dosage: 3,750 mg of niacin twice daily (after gradual dose increase), 150 mg of dihydroberberine twice daily, 50 mg of taxifolin (with 500 mg of vitamin C and 15 mg of zinc) twice daily, 50 mg of tocotrienols twice daily

A combination of supplements, including the NAD+ precursor nicotinic acid, improves cholesterol, allowing some participants to cease taking statins.  

Study conducted by Professor Emeritus Joseph Keenan, MD, at the University of Minnesota. 

Nicotinic Acid

Model: Male C57BL/6 mice given continuous alcohol for 4 weeks 
Dosage: 350 mg/kg/day of nicotinamide riboside chloride for 2 weeks

The NAD+ (nicotinamide adenine dinucleotide) precursor nicotinamide riboside chloride (NRC) counteracts neuronal damage caused by alcohol consumption in mice. 

Researchers Identify Key Cellular Changes Around Age 50 That Accelerate Aging

The Chinese Academy of Sciences' findings may explain why aging makes us sicker and suggest new ways to detect and reverse aging.

(Chinese Academy of Sciences | Ferdowsi University of Mashhad)

Aging &amp; Longevity

A vaccine targeting an enzyme that breaks down NAD+, called CD38, counteracts signs of aging in mice. 


Search Result: dementia risk

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Researchers Identify Key Cellular Changes Around Age 50 That Accelerate Aging

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