Life Biosciences reports preliminary visual-field improvements in two of three glaucoma patients treated with the experimental therapy developed by Dr. David Sinclair’s Harvard team, ER-100.

Aging &amp; Longevity

The Future of Longevity: Could Humans Really Live to 150?

A TIME Magazine longevity panel, featuring Harvard’s David Sinclair, explores whether breakthroughs in AI, cellular rejuvenation, and research on sex differences could help today’s children live far longer.

(An image illustrating the possibility of some humans achieving a 150-year lifespan in the future | NAD.com)

David Sinclair and Jennifer Garrison discuss whether AI advancements, cellular rejuvenation techniques, and research on sex differences can make a 150-year lifespan possible.

The Harvard geneticist discussed an early human trial, unpublished mouse results, and an AI-assisted search for chemical rejuvenation therapies on the Joe Rogan Experience. 

Cellular reprogramming, an innovative age-reversal technology, stimulates the regeneration of heart cells after a heart attack in mice. 

Cardiovascular

<p>Model: Young (2- to 4-month-old) and aged (9- to 10-month-old) C57Bl/6JR mice, APP/PS1 mice, and 5xFAD mice<br />
Dosage: 0.2 mg/mL of doxycycline in drinking water starting at least 7 days before surgery and ceased 2 days before the partial cellular reprogramming window for engram tagging, after which it was immediately reintroduced</p>


Gene Therapy Restores Cognitive Function in Aging and Alzheimer’s Disease

Delivering a gene therapy targeting ensembles of neurons that store memories restores learning and memory capabilities in mouse models of aging and Alzheimer’s disease.

(The study’s principal investigator, Professor Johannes Gräff | 24 Heures)

A partial cellular reprogramming gene therapy targeting memory trace cells restores facets of learning and memory in aged mice and those modeling Alzheimer’s disease.

Search Result: cellular reprogramming

David Sinclair’s Experimental Cell-Rejuvenation Therapy Shows Early Vision Signals in First Human Trial

The Future of Longevity: Could Humans Really Live to 150?

“Prophet of Longevity” David Sinclair Reveals New Anti-Aging Data

New Age-Reversing Tech Helps Heart Regenerate, Scientists Find

Gene Therapy Targeting Memory-Encoding Neurons Restores Cognitive Function in Aging and Alzheimer’s Disease