Model: 6-week-old ICR mice
Dosage: 250 mg/kg per day or 500 mg/kg per day of glucosamine and 100 mg/kg per day or 200 mg/kg per day of aspirin for either eight (acute alcohol exposure model) or 40 days (chronic alcohol exposure model)

New Study Supports Repurposing Glucosamine Against Liver Aging

A sugar-like compound found in cartilage called glucosamine reduces dysfunctional cells (senescent cells) in the liver and attenuates liver damage from alcohol consumption in mice.

(Glucosamine capsules | MedicalNewsToday)

Glucosamine alleviates liver damage from alcohol consumption in mice, supporting its potential for use against alcoholic liver disease.

Aging &amp; Longevity

Scientists find that meloxicam preserves muscle mass and strength in aged mice while sustaining mitochondrial function and activating multiple molecules associated with longevity. 


Skin &amp; Muscle

Model: 5xFAD mouse model for Alzheimer’s disease 
Dosage: Oral administration of 457 mg/kg/day of glucosamine for 2 weeks

Supplementing with glucosamine, a compound found in our cartilage, increases the risk of mortality from dementia in certain individuals while also worsening memory in mice that model dementia. 

Study led by Dr. Ramon Sun on the far right (image: mbi.ufl.edu). 

Brain &amp; Neurons

Model: Female New Zealand white rabbits
Dosage: 20 mg/kg of fisetin (the authors did not state the administration route).

Fisetin Combats Heart Disease by Eliminating Senescent Cells

Fisetin reduces susceptibility to a heart condition called atrial fibrillation (AF) and eliminates age-promoting senescent cells in aged rabbits.  

On the right is Principal Investigator Gideon Koren, MD (image: brownhealth.org).

Cardiovascular

Researchers Identify Key Cellular Changes Around Age 50 That Accelerate Aging

The Chinese Academy of Sciences' findings may explain why aging makes us sicker and suggest new ways to detect and reverse aging.

(Chinese Academy of Sciences | Ferdowsi University of Mashhad)

Search Result: arthritis

New Study Supports Repurposing Glucosamine Against Liver Aging and Alcoholic Liver Disease

Repurposed Arthritis Drug Counters Muscle Mass Loss with Age, New Study Shows

Common Joint Health Supplement May Progress Dementia, New Study Finds

Natural Compound Fisetin Combats Heart Disease by Eliminating Senescent Cells: New Brown University Study

Researchers Identify Key Cellular Changes Around Age 50 That Accelerate Aging