Participants: Adults over the age of 60 
Dosage: 3,750 mg of niacin twice daily (after gradual dose increase), 150 mg of dihydroberberine twice daily, 50 mg of taxifolin (with 500 mg of vitamin C and 15 mg of zinc) twice daily, 50 mg of tocotrienols twice daily

A combination of supplements, including the NAD+ precursor nicotinic acid, improves cholesterol, allowing some participants to cease taking statins.  

Study conducted by Professor Emeritus Joseph Keenan, MD, at the University of Minnesota. 

Nicotinic Acid

Model: Male ApoE−/− mice fed a high-fat diet for 12 weeks to induce atherosclerosis.
Dosage: Methyl-β-cyclodextrin (Mß-CD) at 2.0 g/kg, subcutaneous injection, twice a week

 A new study shows cyclodextrin reduces artery plaques in mice by lowering cholesterol and blocking inflammatory cell death. 

Cardiovascular

Columbia University scientists find that inflammation increases the risk of common chronic age-related diseases only in people from industrialized populations. 

Columbia University in New York City (image: Columbia.edu). 

Immunity

Model: 24-month-old male C57BL/6J mice 
Dosage: 1% w/v of betaine for three weeks

The naturally occurring compound betaine is elevated in healthy adults after long-term exercise and mitigates signs of aging in mice. 

University of California (UC) Berkeley scientists moderately extend the lifespan of old mice by giving them oxytocin (sometimes called the "love hormone") and a compound that inhibits inflammation.  

Search Result: anti-inflammatory

NAD+ Boosting Supplement Challenges Cholesterol-Lowering Statins in Anti-Aging Research

Scientists Find a New Way to Stop Dangerous Artery Plaques From Growing

The Inflammation Myth: New Insights on Aging

“Exercise in a Pill”? Betaine Supplement Shows Anti-Aging Benefits

New UC Berkeley Study: “Love Hormone” and Anti-Inflammatory Combo Extend Life