Model: Eight-week-old C57BL/6J mice treated with 300 mg/kg/day of D-galactose by subcutaneous injections for eight weeks
Dosage: 100 mg/kg/day of NMN in drinking water for eight weeks and 5 × 10 5 hUC-MSCs suspended in 150 µL of PBS via tail vein injection on the first day of weeks five through seven

NMN Enhances Stem Cell Therapy’s Effects on Immune Aging in Latest Study

Combining NMN with umbilical cord–derived stem cells improved motor and cognitive function while reducing markers of immune aging in mice with chemically induced aging.

(An image of human umbilical cord-derived mesenchymal stem cells [white structures] under a microscope | Vitro Biopharma)

NMN with a stem cell therapy reduced markers of immune aging and improved coordination and memory performance in mice with chemically induced aging-like changes.

Immunity

A new scientific review questions how much researchers actually know about fasting’s ability to enhance cellular recycling—particularly in humans.

The spherical structure depicts an autophagolysosome. 

Aging &amp; Longevity

Model: Young acquired niacin dependency (ANDY) mice. 
Dosage: 30 mg/kg/day of niacin

Mice engineered to have low body-wide NAD+ levels exhibit a shortened lifespan and widespread physical decline, which is largely reversed with the NAD+ booster niacin. 

Life Biosciences reports preliminary visual-field improvements in two of three glaucoma patients treated with the experimental therapy developed by Dr. David Sinclair’s Harvard team, ER-100.

The Harvard geneticist discussed an early human trial, unpublished mouse results, and an AI-assisted search for chemical rejuvenation therapies on the Joe Rogan Experience. 

Search Result: anti-aging

NMN Enhances Stem Cell Therapy’s Effects on Immune Aging in Latest Study

Does Fasting Really Trigger Autophagy? New Study Challenges Popular Longevity Belief

New Mayo Clinic Study: Forcibly Depleting NAD+ Shortens Lifespan

David Sinclair’s Experimental Cell-Rejuvenation Therapy Shows Early Vision Signals in First Human Trial

“Prophet of Longevity” David Sinclair Reveals New Anti-Aging Data