Model: Apoe−/− C57BL/6J mice fed a high-fat diet
Dosage: 1 × 109 CFU per 0.1 mL of Bacteroides uniformis administered to mice via oral gavage for 12 weeks and 25 mg/kg of pentadecanoic acid via oral gavage three times per week for eight weeks

New Study: Gut Bacteria Metabolite Reduces Arterial Plaque Burden by 50%

Researchers identified pentadecanoic acid, a gut-bacteria-produced metabolite, that lowered LDL cholesterol and limited arterial plaque buildup in mice.

(A depiction of various gut bacteria in the intestines | NAD.com)

A gut bacterial metabolite reduced arterial plaque buildup by about 50% in mice, revealing a potential link between gut microbes and cholesterol regulation.

Cardiovascular

Protein Restriction and Longevity: Can Limiting Protein Intake Support Healthy Aging?

University of Wisconsin researchers examine how reducing dietary protein intake may reshape nutrient sensing, metabolism, mitochondrial function, and other pathways linked to healthier aging.

(One of the leading authors on the Cell Press Blue article, Dr. Dudley Lamming | University of Wisconsin)

Researchers examine how restricting protein intake can improve metabolic health and influence aging-related pathways to extend healthspan and lifespan.

Aging &amp; Longevity

Model: 6- to 8-week-old male C57BL/6J mice
Dosage: 0.5 mg/kg of isolated mitochondria injected every two days for six injections in the tail vein

Mitochondrial Transplantation Rejuvenates Aging Hearts, Study Finds

Transplantation of the cell’s powerhouses (mitochondria) improves heart function by restoring mitophagy (the cellular process that clears damaged mitochondria) in a mouse model of cardiac aging.

(An image depicting mitochondria [ovoid structures] in cardiac tissue | NAD.com)

Mitochondrial transplantation improves heart function by restoring the cellular process that clears damaged mitochondria in a mouse model of cardiac aging.

Model: Chronically stressed mice 
Dosage: 9 mg/kg/day of L-serine, or 5 mg/kg/day of dasatinib combined with 50 mg/kg/day of quercetin

Supplementing chronically stressed mice with L-serine, an amino acid, counters signs of anxiety and diabetes while diverting age-promoting senescent cells within the brain’s fear center. 

Diabetes &amp; Obesity

Repurposing Erectile Dysfunction Pills for Longevity

Some people are taking erectile dysfunction medications like Cialis and Viagra for more than sex—rather, to help them live longer.

(Tablets of the erectile dysfunction drugs Cialis and Viagra | Prostate Prognosis)

People have started repurposing erectile dysfunction medications, such as Cialis and Viagra, to help them live longer.

Search Result: Vascular disease

New Study: Gut Bacteria Metabolite Reduces Arterial Plaque Burden by 50%

Protein Restriction and Longevity: Can Limiting Protein Intake Support Healthy Aging?

Mitochondrial Transplantation Rejuvenates Aging Hearts, Study Finds

Cheap Supplement May Counter Stress-Induced Diabetes, Anxiety, and Brain Senescence, According to New Study

Repurposing Erectile Dysfunction Pills for Longevity