New Data Shows Combining Two Therapies Doubles Lifespan in Mouse Model

Immorta Bio, a biotech company, released results showing that combining its vaccine and stem cell therapy remarkably doubled lifespan in a mouse model of aging.

The biotech company, Immorta Bio, presented data showing a remarkable doubling of lifespan in a mouse model of aging with a combination of its vaccine and stem cell therapy.

Industry

<p>Model: Young (2- to 4-month-old) and aged (9- to 10-month-old) C57Bl/6JR mice, APP/PS1 mice, and 5xFAD mice<br />
Dosage: 0.2 mg/mL of doxycycline in drinking water starting at least 7 days before surgery and ceased 2 days before the partial cellular reprogramming window for engram tagging, after which it was immediately reintroduced</p>


Gene Therapy Restores Cognitive Function in Aging and Alzheimer’s Disease

Delivering a gene therapy targeting ensembles of neurons that store memories restores learning and memory capabilities in mouse models of aging and Alzheimer’s disease.

(The study’s principal investigator, Professor Johannes Gräff | 24 Heures)

A partial cellular reprogramming gene therapy targeting memory trace cells restores facets of learning and memory in aged mice and those modeling Alzheimer’s disease.

Brain &amp; Neurons

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<p data-start="97" data-end="197">Model: Aged mice (18 months old, C57BL/6 strain) and aged rhesus macaques (18–21 years old).</p>
<p data-start="97" data-end="197">Dosage: Mice received 100 µg of EVs^ABPC via tail vein injection twice per week for 4 weeks.<br data-start="297" data-end="300" data-is-only-node="" />Rhesus macaques received 200 µg/kg of EVs^ABPC intravenously once per week for 20 weeks.</p>
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Scientists Discover Deer Antler Stem Cells That Reverse Aging in Mice and Monkeys

Researchers discover that deer antler stem cells can restore bone density, slow aging, and reverse biological age in mice and primates.

Aging &amp; Longevity

<p>Participants: Healthy male adults between the ages of 18 and 50 </p>
<p>Dosage: 714 mg/day of nicotinamide and 19 mg/day of pyridoxine for nine days </p>


In a randomized human trial, combining nicotinamide with vitamin B6 increases stem cell activation and muscle-growth capacity in response to exercise. 

Skin &amp; Muscle

Innovative Computer Model Reveals Aging May Stem from Lost Cellular Purpose

A new computer simulation suggests aging occurs when cells and tissues lose their developmental goals, offering a fresh perspective on rejuvenation strategies.

(The article’s principal investigator, Michael Levin | Tufts Now)

An innovative computer model simulates aging, suggesting that cells and tissues lose their developmental goals, leading to physiological deterioration.

Search Result: Tissue regeneration

Biotech Company Unveils Data Showing Combining Its Two Therapies Doubles Lifespan in Mouse Model

Gene Therapy Targeting Memory-Encoding Neurons Restores Cognitive Function in Aging and Alzheimer’s Disease

Scientists Discover Deer Antler Stem Cells That Reverse Aging in Mice and Monkeys

NAD+ Booster and Vitamin B6 Activate Stem Cells to Counter Muscle Shrinkage, New Studies Show

Innovative Computer Model Reveals Aging May Stem from Lost Cellular Purpose