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<p class="PDq2pG_selectionAnchorContainer" data-start="0" data-end="125">Model: 4-week-old <span class="hover:entity-accent entity-underline inline cursor-pointer align-baseline"><span class="whitespace-normal">SM/J</span></span> mice (with <span class="hover:entity-accent entity-underline inline cursor-pointer align-baseline"><span class="whitespace-normal">C57BL/6J</span></span> comparison mice)</p>
<p data-start="127" data-end="279" data-is-last-node="" data-is-only-node="">Dosage: Weekly intraperitoneal injections of 40 mg/kg Navitoclax or 5 mg/kg Dasatinib + 50 mg/kg Quercetin from 4 to 6–8 or 17 weeks of age.</p>
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Dasatinib and Quercetin Delay Early-Onset Disc Degeneration in Mice

Researchers find that clearing senescent cells preserves disc structure and slows early-onset disc degeneration in mice.


Aging &amp; Longevity

<p><span style="font-weight: 400;">Participants: Healthy, overweight older adults </span></p>
<p><span style="font-weight: 400;">Dosage: 6 mg/day of spermidine supplemented orally for 13 weeks </span></p>


Oxford scientists find that spermidine, a naturally occurring molecule that declines with age, rejuvenates aging immune cells and improves vaccine protection in older adults. 


Study conducted at the University of Oxford in England. 

Immunity

<p>Participants: Sedentary older adults </p>
<p>Dosage: 6 mg/week of rapamycin </p>


In older adults, the FDA-approved drug rapamycin, associated with prolonging lifespan, blunts improvements in physical performance.

Skin &amp; Muscle

Harvard: Microbiome Depletion Rejuvenates the Aging Brain

Harvard researchers find that aged mice lacking gut bacteria exhibit a brain more like that of young mice. 

The Principal Investigator of the study, Dr. Lee Rubin (image: harvard.edu). 

Brain &amp; Neurons

<p>Model: 14- to 15-month-old male C57BL/6J mice</p>
<p>Dosage: 50 mg injection of 3′-deoxyadenosine (cordycepin) because it was shown not to be absorbed if administered orally </p>


Mushroom Compound Prolongs Lifespan If Taken At Correct Time

In mice, cordycepin—a molecule found in cordyceps mushrooms—prolongs lifespan and improves memory, strength, cardiac function, hormone levels, and metabolism. 


Cordyceps mushrooms (image: antioxi-supplements.com). 

Search Result: Senescence

Dasatinib and Quercetin Delay Early-Onset Disc Degeneration in Mice

Anti-Aging Spermidine Boosts Immune System, New Study Shows

Rapamycin and Exercise: New Study Finds Potential Performance Decline

New Harvard Study: Microbiome Depletion Rejuvenates the Aging Brain

Cordyceps Mushroom Molecule Prolongs Lifespan If Taken At Correct Time of Day, New Study Shows