Participants: Healthy, overweight older adults 
Dosage: 6 mg/day of spermidine supplemented orally for 13 weeks

Oxford scientists find that spermidine, a naturally occurring molecule that declines with age, rejuvenates aging immune cells and improves vaccine protection in older adults. 


Study conducted at the University of Oxford in England. 

Immunity

Participants: Sedentary older adults 
Dosage: 6 mg/week of rapamycin

In older adults, the FDA-approved drug rapamycin, associated with prolonging lifespan, blunts improvements in physical performance.

Skin &amp; Muscle

Harvard: Microbiome Depletion Rejuvenates the Aging Brain

Harvard researchers find that aged mice lacking gut bacteria exhibit a brain more like that of young mice. 

The Principal Investigator of the study, Dr. Lee Rubin (image: harvard.edu). 

Brain &amp; Neurons

Model: 14- to 15-month-old male C57BL/6J mice
Dosage: 50 mg injection of 3′-deoxyadenosine (cordycepin) because it was shown not to be absorbed if administered orally

Mushroom Compound Prolongs Lifespan If Taken At Correct Time

In mice, cordycepin—a molecule found in cordyceps mushrooms—prolongs lifespan and improves memory, strength, cardiac function, hormone levels, and metabolism. 


Cordyceps mushrooms (image: antioxi-supplements.com). 

Aging &amp; Longevity

Model: 11-month-old male C57BL/6J mice 
Dosage: 30 mg/kg/day of NTX-748 (based on a small molecule called 78c) for 4 months, administered orally

Blocking NAD+ Breakdown Improves Cognitive and Physical Performance

Buck Institute scientists find that blocking the CD38 enzyme, which elevates NAD+ (nicotinamide adenine dinucleotide), counteracts age-related cognitive and physical decline in mice.  

Study conducted at the Buck Institute for Research on Aging (image: linkedin.com).

Search Result: Senescence

Spermidine Boosts Immune Cells and Vaccine Protection, New Study Shows

Rapamycin and Exercise: New Study Finds Potential Performance Decline

New Harvard Study: Microbiome Depletion Rejuvenates the Aging Brain

Cordyceps Mushroom Molecule Prolongs Lifespan If Taken At Correct Time of Day, New Study Shows

Blocking NAD+ Breakdown Improves Cognitive and Physical Performance: New Study