Model: Eight-week-old C57BL/6J mice treated with 300 mg/kg/day of D-galactose by subcutaneous injections for eight weeks
Dosage: 100 mg/kg/day of NMN in drinking water for eight weeks and 5 × 10 5 hUC-MSCs suspended in 150 µL of PBS via tail vein injection on the first day of weeks five through seven

NMN Enhances Stem Cell Therapy’s Effects on Immune Aging in Latest Study

Combining NMN with umbilical cord–derived stem cells improved motor and cognitive function while reducing markers of immune aging in mice with chemically induced aging.

(An image of human umbilical cord-derived mesenchymal stem cells under a microscope | NAD.com)

NMN with a stem cell therapy reduced markers of immune aging and improved coordination and memory performance in mice with chemically induced aging-like changes.

Immunity

Life Biosciences reports preliminary visual-field improvements in two of three glaucoma patients treated with the experimental therapy developed by Dr. David Sinclair’s Harvard team, ER-100.

Aging &amp; Longevity

The Future of Longevity: Could Humans Really Live to 150?

A TIME Magazine longevity panel, featuring Harvard’s David Sinclair, explores whether breakthroughs in AI, cellular rejuvenation, and research on sex differences could help today’s children live far longer.

(An image illustrating the possibility of some humans achieving a 150-year lifespan in the future | NAD.com)

David Sinclair and Jennifer Garrison discuss whether AI advancements, cellular rejuvenation techniques, and research on sex differences can make a 150-year lifespan possible.

The Harvard geneticist discussed an early human trial, unpublished mouse results, and an AI-assisted search for chemical rejuvenation therapies on the Joe Rogan Experience. 

Model: Old male mice
Dosage: 100 mg/kg/day of ALA administered in drinking water

Restoring the naturally occurring antioxidant, alpha-lipoic acid (ALA), to the gut wall rejuvenates stem cells and counters age-related gut degeneration in mice and human models. 

Images of miniature intestines developed from intestinal stem cells. 

Search Result: Rejuvenation

NMN Enhances Stem Cell Therapy’s Effects on Immune Aging in Latest Study

David Sinclair’s Experimental Cell-Rejuvenation Therapy Shows Early Vision Signals in First Human Trial

The Future of Longevity: Could Humans Really Live to 150?

“Prophet of Longevity” David Sinclair Reveals New Anti-Aging Data

Alpha-Lipoic Acid Rejuvenates Stem Cells & Improves Gut, New Study Shows