Johns Hopkins Research Review: Parkinson’s Drug Extends Multiple Species' Lifespan

L-deprenyl, a drug used to treat Parkinson’s disease and major depressive disorder, has been shown to modestly extend lifespan across species, from mice to rats to hamsters.

L-deprenyl, a drug prescribed to treat Parkinson’s disease and major depressive disorder, has been shown to modestly extend average lifespan across mammalian model organism species.

Aging &amp; Longevity

Model: Male Sprague-Dawley rats 
Dosage: 400 mg/kg of magnesium L-theanine and 600 mg/kg of nicotinamide riboside administered orally for 40 days

Scientists find that treating rats with magnesium L-theanine and nicotinamide riboside (NR) counteracts stress-induced metabolic, gut, and liver aging. 

Study conducted by researchers from Firat University in Turkey (image: turkeyuniversity.org)

Cutting-edge technology has allowed scientists to examine young and old brains with single-cell resolution, gaining insights into how we can rejuvenate our brain cells to stay sharp. 


Stanford University scientist and corresponding author on the new study, Dr. Anne Brunet (image: labxchange.org). 

Brain &amp; Neurons

A 167-study analysis reveals that rapamycin prolongs lifespan as effectively as dietary restriction: reducing food intake without entering a state of malnourishment.

Model: UM-HET3 mice and 5XFAD mice 
Dosage: UM=HET3 mice received 180 mg/kg canagliflozin in chow starting at seven months of age, and FXFAD mice received 180 mg/kg canagliflozin in chow beginning at three months of age

New Study: Diabetes Medication Improves Cognition and Alleviates Alzheimer’s Progression

The diabetes drug canagliflozin improves learning and memory in middle-aged male mice and reduces brain plaques in Alzheimer’s model mice.

The FDA-approved diabetes medication canagliflozin improves cognition in a mouse model of Alzheimer’s disease in males only.

Search Result: Rats

Johns Hopkins Research Review: Parkinson’s Drug Shown to Extend Lifespan Across Mammalian Species

New Research: Magnesium, L-Theanine, NAD+ Combo Counters Stress Aging

Brain Aging Interventions: Key Insights from a New Stanford Study

Anti-Aging Drug Rapamycin Extends Life as Much as Dieting, New Study Shows

Diabetes Medication Improves Cognition and Alleviates Alzheimer’s Progression, Suggests New Study