Model: Young C57BL/6J mice fed a high protein (56% of daily calories) diet for 20 weeks 
Dosage: Injection with either 400 mg/kg of NMN or 20 mg/kg of 78c for 4 weeks

High protein intake improves the body composition of aged mice, but it lowers NAD+ (nicotinamide adenine dinucleotide) levels and promotes metabolic aging. 

Metabolism

Model: Male COX7RP transgenic mice with systemic overexpression of COX7RP, aged under standard laboratory conditions and compared with age-matched wild-type controls.
Dosage: Not applicable. COX7RP activity was increased via genetic overexpression rather than drug administration.

Boosting mitochondrial efficiency by increasing COX7RP activity extended lifespan in mice while improving energy production and reducing inflammation.

Aging &amp; Longevity

Model: Naturally aged 24-month-old C57BL/6 mice 
Dose: 0.1 mg/kg/day of folic acid administered orally for 12 months

Supplementation with vitamin B9, also known as folic acid or folate, prevents cellular senescence and slows vascular aging in naturally aged mice.  

Cardiovascular

Model: 22-month-old male C57BL/6NIH mice 
Dosage: 400 mg/kg of NR for eight weeks, administered in food

Treating aged mice with the NAD+ (nicotinamide adenine dinucleotide) precursor NR (nicotinamide riboside) improves memory and reduces pro-inflammatory immune cells.

Senior members of the research team, Dr. Bruce R. Troen and Dr. Kenneth L. Seldeen (image: buffalo.edu).  

Brain &amp; Neurons

Elevating the naturally occurring molecule NAD+ (nicotinamide adenine dinucleotide) improves memory and corrects gene-splicing patterns in a worm and a mouse model for dementia. 

Senior author on the study, Dr. Evandro Fang (front left), with some students (image: evandrofanglab.com)

Search Result: RESTORIN

High Protein Intake Promotes Aging by Lowering NAD+ Levels

New Study Shows Increasing COX7RP Improves Energy Production and Extends Lifespan

New Study: Vitamin B9 Combats Cell Senescence to Slow Vascular Aging

NAD+ Supplement Improves Memory & Brain Immune Cells, New Study Reveals

New Research: Correcting Gene Splicing with NAD+ Boosts Memory