Human studies show that a higher intake of the naturally occurring molecule spermidine may prevent cognitive impairments and dementia while improving longevity. 


Brain &amp; Neurons

Model: C3B6F1 hybrid mice 
Dosage: 42 mg/kg of rapamycin and 1.44 mg/kg of trametinib in food starting at 6 months of age

Latest Research: Two FDA-Approved Drugs Additively Extend Lifespan

Researchers at the Max Planck Institute have unveiled that combining trametinib with rapamycin, drugs used in cancer treatment, extends average lifespan by 29% in female mice and 27% in male mice, respectively.

(The study’s lead author, Linda Partridge | The Biologist)

Combining two cancer treatment drugs, trametinib and rapamycin, extends lifespan by 29% and 27% in middle-aged female and male mice, respectively.

Aging &amp; Longevity

Restoring the essential molecule NAD+ may potentially hold the key to treating Alzheimer’s, as Harvard researchers emphasize the role of low brain NAD+ in this devastating disease.


University of California, Irvine (UCI) scientists identify a NAD+ precursor in mice that declines with age and mitigates age-related kidney decline.


Model: C57BL/6N male mice 
Dosage: AIN-93 M diet with 0.025% (15 mg/kg per day) niclosamide for the Old + NL group or 0.050% (30 mg/kg per day) niclosamide for the Old + NH group, starting at 12 months of age to 21 months of age

Drug Approved Against Tapeworms May Counteract Aging, Suggests New Study

New research suggests niclosamide, approved for human use against tapeworms, alleviates frailty and suppresses the protein complex mTOR, which regulates cell growth, in aged mice.

(The drug niclosamide | Hospital Pharmacy Europe)

Niclosamide, an agent approved for human use against tapeworms, alleviates age-related frailty, suppresses mTOR, and activates autophagy in old mice.

Search Result: RESTORIN

Spermidine: A Promising Nutrient for Brain Health and Cognitive Aging

Latest Research: Two FDA-Approved Drugs Additively Extend Lifespan

Targeting NAD+ for Treating Dementia: New Harvard Op-Ed

A New NAD+ Precursor that Counters Kidney Aging

Drug Approved for Humans Against Tapeworms May Counteract Aging, Similar to Rapamycin, Suggests New Study