Participants: Older adults at risk for dementia. 
Dosage: 2 g/day of DHA

While it entered the brain, two years of high-dose supplementation revealed no cognitive protection from pure docosahexaenoic acid (DHA) in older adults without dementia.


Brain &amp; Neurons

Model: Eight-week-old male C57BL/6J mice treated with 400 mg/kg/day of D-galactose via intraperitoneal injection for 12 weeks to induce accelerated aging.
Dosage: 400 mg/kg/day of Antarctic krill oil administered by oral gavage for 12 weeks, alongside D-galactose treatment. A comparison group received 400 mg/kg/day of fish oil under the same conditions.

Krill Oil Preserves Muscle Strength and Mitochondrial Health During Accelerated Aging

Daily krill oil supplementation preserves muscle strength, endurance, and mitochondrial health in mice with accelerated aging, outperforming fish oil.

Skin &amp; Muscle

Model: Young acquired niacin dependency (ANDY) mice. 
Dosage: 30 mg/kg/day of niacin

Mice engineered to have low body-wide NAD+ levels exhibit a shortened lifespan and widespread physical decline, which is largely reversed with the NAD+ booster niacin. 

The Harvard geneticist discussed an early human trial, unpublished mouse results, and an AI-assisted search for chemical rejuvenation therapies on the Joe Rogan Experience. 

Aging &amp; Longevity

Aging Clocks Applied to Human Trial Data Support AI-Designed Drug Lowering Age

Six proteomics-based aging clocks (age assessments from large-scale analyses of proteins) agreed that patients treated with the AI-designed drug rentosertib appeared younger.

(A vial containing rentosertib tablets | New York Times)

The AI-designed drug rentosertib was shown to lower biological age across six aging clocks in patients with idiopathic pulmonary fibrosis.

Search Result: Physical Performance

New USC Study Reveals Which Popular Omega-3 Supplement Fails to Protect the Brain

Krill Oil Preserves Muscle Strength and Mitochondrial Health During Accelerated Aging

New Mayo Clinic Study: Forcibly Depleting NAD+ Shortens Lifespan

“Prophet of Longevity” David Sinclair Reveals New Anti-Aging Data

Aging Clocks Applied to Human Trial Data Support AI-Designed Drug Making People Younger