<p>Model: Ten-month-old male EFAD mice<br />
Dosage: 14.4 ppm of alfatradiol in diet for five months</p>


USC Study: Longevity-Promoting Drug Counteracts a Genetic Predisposition to Alzheimer's

The drug alfatradiol, also known as 17ɑ-estradiol, reduces cognitive errors on a test of memory and lowers neuronal plaques in mice genetically predisposed to Alzheimer’s disease.

(The University of Southern California | College Matchpoint)

Researchers unveil data suggesting the drug alfatradiol improves signs of frailty, reduces cognitive errors, and reduces neuronal plaques in mice with a genetic predisposition to Alzheimer’s disease.

Brain &amp; Neurons

Human studies show that a higher intake of the naturally occurring molecule spermidine may prevent cognitive impairments and dementia while improving longevity. 


Discover proven anti-aging and longevity drugs that extend lifespan. Lifestyle, nutrition, sleep, exercise, and toxin avoidance, all in the best and most comprehensive guide.

Explore the most effective longevity interventions—nutrition, fasting, sleep, exercise, and mouse-tested drugs that extend lifespan in real studies.

Longevity Prescription: Diet, Fasting, and Proven Anti-Aging Strategies

Aging &amp; Longevity

Restoring the essential molecule NAD+ may potentially hold the key to treating Alzheimer’s, as Harvard researchers emphasize the role of low brain NAD+ in this devastating disease.


Ranked fourth on the Rejuvenation Olympics leaderboard, 30-year-old Siim Land lists the supplements he takes to stay young. 


Search Result: Neurodegeneration

USC Study Suggests Longevity-Promoting Drug Counteracts a Genetic Predisposition to Alzheimer’s

Spermidine: A Promising Nutrient for Brain Health and Cognitive Aging

Longevity Prescription

Targeting NAD+ for Treating Dementia: New Harvard Op-Ed

Fourth Slowest Ager in World Siim Land’s 2025 Longevity Supplement Protocol