Model: Old male mice
Dosage: 100 mg/kg/day of ALA administered in drinking water

Restoring the naturally occurring antioxidant, alpha-lipoic acid (ALA), to the gut wall rejuvenates stem cells and counters age-related gut degeneration in mice and human models. 

Images of miniature intestines developed from intestinal stem cells. 

Aging &amp; Longevity

Top Evidence-Based Interventions to Lower Biological Age

Epigenetic aging clocks estimate biological age based on DNA molecular tagging patterns, and interventions like semaglutide and ketamine reduce these estimates in humans.

(The principal investigator behind the review on interventions that influence biological age, Dr. David Sinclair | The Society of the Four Arts)

As reviewed in this article, epigenetic aging clocks have estimated the effects of pharmaceutical interventions, lifestyle habits, supplements, and clinical interventions on biological age.

Participants: Healthy, overweight older adults 
Dosage: 6 mg/day of spermidine supplemented orally for 13 weeks

Oxford scientists find that spermidine, a naturally occurring molecule that declines with age, rejuvenates aging immune cells and improves vaccine protection in older adults. 


Study conducted at the University of Oxford in England. 

Immunity

Japanese scientists have found that reducing NAD+ (nicotinamide adenine dinucleotide) transport into mitochondria within the fat tissue of mice induces metabolic dysregulation and obesity. 

Duke University scientists have successfully induced new neuronal connections in the brains of mice, leading to improvements in social interaction and stress resilience. 

Search Result: NAD

Alpha-Lipoic Acid Rejuvenates Stem Cells & Improves Gut, New Study Shows

Top Evidence-Based Interventions to Lower Biological Age

Spermidine Boosts Immune Cells and Vaccine Protection, New Study Shows

NAD+ Transporter Prevents Obesity Caused by Aging: New Study Shows

Can We Reverse Memory Loss? Duke Scientists Find New Way to Rewire the Brain