Longevity Medicine’s Peptides Craze: Evidence, Delivery Challenges, and Expert Opinions

Advocates say peptides offer significant benefits against aging, while researchers warn that these claims outpace the evidence.

(Peptides are often injected with a syringe | Harvard Health)

Proponents say peptides offer significant effects against aging, while skeptical scientists say these claims outpace the evidence.

Aging &amp; Longevity

How to Slow Aging: 7 Tips from a Danish Aging Expert

Danish aging expert Morten Scheibye-Knudsen shares seven ways to slow aging, including taking NR (nicotinamide riboside) and the diabetes medication metformin.

(Professor Morten Scheibye-Knudsen | BBC Science Focus)

Danish aging expert Morten Scheibye-Knudsen does things like taking NR and metformin to slow his biological aging

Model: Female Balb/c mice exposed to ultraviolet radiation 
Dosage: 2%, 5%, 7.5%, or 12.5% of nicotinamide (weight/volume) applied topically, once daily, five times per week

The NAD+ (nicotinamide adenine dinucleotide) precursor nicotinamide prevents skin aging, in part by targeting age-promoting senescent cells in mice. 


Model: Skin, arterial, and lens tissue from donors between the ages of 20 and 25 and also 75 
Dosage: 5 µM solution of CMLase, incubated overnight

Bioengineered Enzyme Shows Ability to Reverse Molecular Aging in Human Tissue

An engineered enzyme reverses age-related protein damage that researchers have long thought irreversible in human eye, skin, and artery tissues.

(A bioengineered enzyme [purple structure] cleaves a prevalent type of AGE [brown glob] on protein residues that are part of protein filaments [dull green chains] | The Scientist)

A bioengineered enzyme reverses age-related protein damage, long thought of as irreversible damage, in human lens, skin, and artery tissues.

Basic Research

Model: Male Wistar rats 
Dosage: 1.5 g/kg/day of orally administered glycine for 5 months

Glycine, an amino acid shown to extend the lifespan of mice, moderately extends the lifespan of flies and counters brain and muscle degeneration in aged rats. 

Search Result: NAD

Longevity Medicine’s Peptides Craze: Evidence, Delivery Challenges, and Expert Opinions

How to Slow Aging: 7 Tips from a Danish Aging Expert

NAD+ Booster Nicotinamide Counters Skin Aging and Cell Senescence, New Study Shows

New Research: Bioengineered Enzyme Shows Ability to Reverse Molecular Aging in Human Tissue

Glycine Extends Life & Counters Brain and Muscle Degeneration, New Study Shows