Model: 5xFAD mouse model for Alzheimer’s disease 
Dosage: Oral administration of 457 mg/kg/day of glucosamine for 2 weeks

Supplementing with glucosamine, a compound found in our cartilage, increases the risk of mortality from dementia in certain individuals while also worsening memory in mice that model dementia. 

Study led by Dr. Ramon Sun on the far right (image: mbi.ufl.edu). 

Brain &amp; Neurons

Russia’s $27 Billion Bet on Beating Aging—Hype or Hope?

With an ambitious goal of conquering aging, Russia is investing $26 to $28 billion in a national health initiative.

(Russian leader, Vladimir Putin | RBC-Ukraine)

Aging &amp; Longevity

Top Evidence-Based Interventions to Lower Biological Age

Epigenetic aging clocks estimate biological age based on DNA molecular tagging patterns, and interventions like semaglutide and ketamine reduce these estimates in humans.

(The principal investigator behind the review on interventions that influence biological age, Dr. David Sinclair | The Society of the Four Arts)

As reviewed in this article, epigenetic aging clocks have estimated the effects of pharmaceutical interventions, lifestyle habits, supplements, and clinical interventions on biological age.

Participants: Healthy, overweight older adults 
Dosage: 6 mg/day of spermidine supplemented orally for 13 weeks

Oxford scientists find that spermidine, a naturally occurring molecule that declines with age, rejuvenates aging immune cells and improves vaccine protection in older adults. 


Study conducted at the University of Oxford in England. 

Immunity

Participants: Older adults (ages 60 to 80) with mild cognitive impairment 
Dosage: 320 mg/day of anthocyanin capsules for 24 weeks

Anthocyanin, a compound found in berries, reduces inflammation and heart disease markers in older adults at risk for dementia.  

Lead author of the study, Dr. Miguel Germán Borda (image: noticias.cun.es).

Search Result: Mortality

Common Joint Health Supplement May Progress Dementia, New Study Finds

Russia’s $27 Billion Bet on Beating Aging—Hype or Hope?

Top Evidence-Based Interventions to Lower Biological Age

Anti-Aging Spermidine Boosts Immune System, New Study Shows

Anthocyanin Supplement Shows Anti-Inflammatory and Heart Health Benefits in New Study