Model: 6- to 8-week-old male C57BL/6J mice
Dosage: 0.5 mg/kg of isolated mitochondria injected every two days for six injections in the tail vein

Mitochondrial Transplantation Rejuvenates Aging Hearts, Study Finds

Transplantation of the cell’s powerhouses (mitochondria) improves heart function by restoring mitophagy (the cellular process that clears damaged mitochondria) in a mouse model of cardiac aging.

(An image depicting mitochondria [ovoid structures] in cardiac tissue | NAD.com)

Mitochondrial transplantation improves heart function by restoring the cellular process that clears damaged mitochondria in a mouse model of cardiac aging.

Cardiovascular

Model: SAMP8 mice (5 months old) and C57BL/6 mice (16 months old)
Dosage: 1.5 mg/kg of urolithin A was administered by intraperitoneal injection three times per week (Monday, Wednesday, and Friday) for 8 weeks.

Study shows that urolithin A preserves memory and cognitive function during aging when treatment begins before age-related decline, but does not reverse cognitive impairment once it is established.

Brain &amp; Neurons

Top Evidence-Based Interventions to Lower Biological Age

Epigenetic aging clocks estimate biological age based on DNA molecular tagging patterns, and interventions like semaglutide and ketamine reduce these estimates in humans.

(The principal investigator behind the review on interventions that influence biological age, Dr. David Sinclair | The Society of the Four Arts)

As reviewed in this article, epigenetic aging clocks have estimated the effects of pharmaceutical interventions, lifestyle habits, supplements, and clinical interventions on biological age.

Aging &amp; Longevity

How to Boost Mitochondrial Tissue Density and Quality for Longevity

Lifestyle hacks contrived to promote the tissue density and quality of mitochondria (the cell’s powerhouses) can aid in the efficient generation of cellular energy and reduce inflammation, thereby promoting longevity.

(A colorized image of mitochondria taken with a transmission electron microscope | UC San Diego Today)

Exercise, nutritional support, and lifestyle hacks like cold exposure can all help mitigate mitochondrial dysfunction, a key hallmark of aging.

Participants: Healthy middle-aged to older adults (average age: ~53 years)
Dosage: 1,000 mg/day of urolithin A for 28 days

Supplementing healthy adults with urolithin A —a compound produced by our gut bacteria— counters signs of age-related immune system decline.  

Principal investigator Dr. Florian R. Greten (image: hessen-schafft-wissen.de).

Search Result: Mitophagy

Mitochondrial Transplantation Rejuvenates Aging Hearts, Study Finds

Urolithin A Preserves Memory During Aging When Treatment Begins Early, Study Shows

Top Evidence-Based Interventions to Lower Biological Age

How to Boost Mitochondrial Tissue Density and Quality for Longevity

Urolithin Supplement Counters Immune System Aging, New Human Trial Shows