Seragon’s RESTORIN and the Evolution of Aging Interventions Containing NAD+ Precursors

Aging interventions that include NAD+ precursors have evolved, adding components targeting various hallmarks of aging, from inflammation to cell waste elimination.

Some aging intervention products with NAD+ precursors, like Seragon’s Restorin, have evolved to include additional components targeting multiple hallmarks of aging.

Aging &amp; Longevity

Model: C57BL/6J mice
Dosage: 500 mg/kg/day of Urolithin A in food

Supplementing with urolithin A prevents age-related hearing loss and mitochondrial dysfunction in mice. 

Brain &amp; Neurons

The large-scale preclinical study shows that SRN-901 significantly extends lifespan and healthspan while improving a great number of aging parameters.


Seragon Biosciences increases the lifespan and healthspan of mice in one of the largest studies of its kind. 

Model: HSCs derived from the bone marrow of anonymous old adults (58–77 years old); Old mice (81–84 weeks old).
Dosage: Old mice were fed with a control (black) or urolithin A (UA) supplemented (red) diet (50 mg kg/day) for 16 weeks.

Urolithin A Can Revitalize Blood Stem Cells in People and Mice, Study Finds 

This mitochondrial modulator helps old human blood stem cells grow and copy themselves more efficiently, and it also helps blood stem cells make blood and immune systems for old mice. 


Immunity

Model: 24- to 26-month-old male C57BL/6J mice for heart and muscle function experiments
Dosage(oral): 50 mg/kg/day urolithin A

Urolithin A — prevalent in pomegranate — improves the heart health and muscle strength of aged mice by stimulating mitophagy — the destruction of damaged mitochondria. 

CEO of Amazentis (the company that sponsored the study), Chris Rinsch holding a pomegranate (photo: Oliver Evard). 

Discover the amazing story from the University of Washington about how Urolithin A (UA) can make your heart healthy and your muscles super strong. Get the scoop at NAD.com!

Search Result: Mitophagy

Seragon’s RESTORIN and the Evolution of Aging Interventions Containing NAD+ Precursors

Urolithin A Anti-Aging Supplement Prevents Hearing Loss, New Research Shows

Seragon’s Aging Intervention Drug SRN-901 Achieves One of the Largest Extensions of Lifespan and Healthspan to Date

Urolithin A Can Revitalize Blood Stem Cells in People and Mice, Study Finds

Urolithin A Restores Heart and Muscle Vitality, University of Washington Study