Human studies show that a higher intake of the naturally occurring molecule spermidine may prevent cognitive impairments and dementia while improving longevity. 


Brain &amp; Neurons

Model: UM-HET3 mice and 5XFAD mice 
Dosage: UM=HET3 mice received 180 mg/kg canagliflozin in chow starting at seven months of age, and FXFAD mice received 180 mg/kg canagliflozin in chow beginning at three months of age

New Study: Diabetes Medication Improves Cognition and Alleviates Alzheimer’s Progression

The diabetes drug canagliflozin improves learning and memory in middle-aged male mice and reduces brain plaques in Alzheimer’s model mice.

The FDA-approved diabetes medication canagliflozin improves cognition in a mouse model of Alzheimer’s disease in males only.

A description of inflammaging and related anti-aging strategies. 


Dr. Claudio Franceschi, the man who coined the term inflammaging (image: u-bordeaux.fr)

Immunity

Participants: Werner syndrome patients 
Dosage: 1 gram of NR per day for 26 weeks

The NAD+ (nicotinamide adenine dinucleotide) booster NR (nicotinamide riboside) improves cardiovascular health in Werner syndrome patients. 

A child with Werner syndrome (image: britannica.com)

Discover proven anti-aging and longevity drugs that extend lifespan. Lifestyle, nutrition, sleep, exercise, and toxin avoidance, all in the best and most comprehensive guide.

Explore the most effective longevity interventions—nutrition, fasting, sleep, exercise, and mouse-tested drugs that extend lifespan in real studies.

Search Result: Mitochondria

Spermidine: A Promising Nutrient for Brain Health and Cognitive Aging

Diabetes Medication Improves Cognition and Alleviates Alzheimer’s Progression, Suggests New Study

What Is Inflammaging? And How to Reverse It

NAD+ Precursor NR Improves Heart Health in People with Accelerated Aging, New Study Shows

Longevity Prescription