Scientists find that meloxicam preserves muscle mass and strength in aged mice while sustaining mitochondrial function and activating multiple molecules associated with longevity. 


Skin &amp; Muscle

Model: Male C57BL/6J (B6) mice (15 months old at the start of treatment)
Dosage: Approximately 5 mg/kg/day of S-1-propenyl-L-cysteine (S1PC) was administered orally for 8 months, from 15 to 23 months of age. S1PC was given in chow containing 0.0025% S1PC, with a second experiment using drinking water to confirm the findings.

Researchers found that a compound found in garlic supports healthier muscle aging by boosting cellular defenses linked to longevity and maintaining physical performance.

Model: SAMP8 mice (5 months old) and C57BL/6 mice (16 months old)
Dosage: 1.5 mg/kg of urolithin A was administered by intraperitoneal injection three times per week (Monday, Wednesday, and Friday) for 8 weeks.

Study shows that urolithin A preserves memory and cognitive function during aging when treatment begins before age-related decline, but does not reverse cognitive impairment once it is established.

Brain &amp; Neurons

Finalist Teams Awarded $1 Million in XPrize Healthspan Contest to Transform Healthy Aging

The XPrize Healthspan—which will split $101 million among teams developing therapeutics to restore muscle, cognitive, and immune function in older adults—has named 10 teams receiving $1 million each.

(XPrize announced the finalists for its XPrize Healthspan competition | XPrize)

The XPrize Healthspan competition has named its top 20 finalist groups that will submit their aging intervention therapies for human trial testing.

Aging &amp; Longevity

Model: Aged C57B/6 mice (between 18-25 months old) 
Dosage: 5 mg/kg/day of ABT-263 was fed to mice while 50 mg/kg/day of dichloroacetate and metformin were injected. For lifespan, they were administered for five consecutive days, followed by a two-day intermission, then an additional five consecutive days, followed by a 6-week intermission.

The combination of dichloroacetate, metformin, and ABT-263 eliminates cancer cells and age-promoting senescent cells while improving endurance and extending lifespan in mice. 


The study was led by Dr. Irina Conboy (image: berkeley.edu). 

Search Result: Mitochondria

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Urolithin A Preserves Memory During Aging When Treatment Begins Early, Study Shows

10 Finalist Teams Awarded $1 Million in XPrize Healthspan Contest to Transform Healthy Aging

Drug Combo Targets Cancer and Senescent Cells to Prolong the Lifespan of Mice, New Study Shows