Model: Primary hippocampal neurons from non-transgenic C57BL/6 (nTg) and triple-transgenic 3xTg-AD mice; age groups: young (2–6 mo), middle (8–11 mo), and old (17–28 mo).
Dosage: Nicotinamide 2 mM + EGCG 2 µM applied to cultured neurons for 16 h (in vitro).

Study shows that brief nicotinamide + EGCG treatment restores neuronal energy in 16–24 hours, restores autophagy, reduces amyloid-beta buildup, and boosts neuron survival by ~22% in aging/Alzheimer’s lab models.

Brain &amp; Neurons

The plant-based compound Harmine counteracts the cellular aging triggered by sleep deprivation in animal models and human cells.

Study conducted at the Leibniz Institute on Aging. 

Aging &amp; Longevity

A Harvard-Trained Doctor’s Top 5 Anti-Aging Supplements

An aging research aficionado, Dr. Josh Helman, shares five supplements that can help fight the effects of aging: nitric oxide, NMN, honokiol, modified citrus pectin, and creatine.

(Harvard-trained aging expert, Dr. Josh Helman | Jupiter Medical Center)

Harvard-trained aging expert Dr. Josh Helman unveils his top five supplements to fight against aging.

Seragon Biosciences has launched its new sleep and longevity optimizer, Enlivien, featuring technology based on a Harvard University collaboration. 


Making CAR-T Cells Young Again: Restoring NAD+ to Rejuvenate Immunotherapy in Aging

A combined treatment of NMN with 78c (a small molecule that inhibits an NAD+-degrading enzyme) enhances the effects of the anti-cancer CAR-T cell therapy in aged mice and human cells.

(A CAR-T cell [red] attacking a cancer cell [blue] | Crown Bioscience Blog)

Search Result: Mitochondria

Nicotinamide + Ergothioneine Reboot Autophagy and Ease Hallmarks of Brain Aging

Scientist May Have Discovered a New Drug that Makes Up for Lost Sleep

A Harvard-Trained Doctor’s Top 5 Anti-Aging Supplements

Enlivien: A New Dawn for Sleep and Longevity

Making CAR-T Cells Young Again: Restoring NAD+ to Rejuvenate Immunotherapy in Aging