Mitochondria-Made Molecule Reverses Memory Loss with Advanced Age

A naturally occurring compound, α-lipoic acid, helped elderly mice think like younger mice by restoring energy balance and calming brain inflammation, according to Second Hospital of Hebei Medical University researchers.

(Alpha-lipoic acid’s molecular structure | Sasha’s of Saratoga)

Brain &amp; Neurons

Harvard: Microbiome Depletion Rejuvenates the Aging Brain

Harvard researchers find that aged mice lacking gut bacteria exhibit a brain more like that of young mice. 

The Principal Investigator of the study, Dr. Lee Rubin (image: harvard.edu). 

Model: 22-month-old male C57BL/6NIH mice 
Dosage: 400 mg/kg of NR for eight weeks, administered in food

Treating aged mice with the NAD+ (nicotinamide adenine dinucleotide) precursor NR (nicotinamide riboside) improves memory and reduces pro-inflammatory immune cells.

Senior members of the research team, Dr. Bruce R. Troen and Dr. Kenneth L. Seldeen (image: buffalo.edu).  

The longevity gene klotho prolongs the lifespan of mice while preventing muscle, bone, and brain aging. 

Miguel Chillón, PhD, and Laura Rodriguez-Estevez, researchers from Universitat Autònoma de Barcelona in Spain, who conducted the study (image: uab.cat) 

Aging &amp; Longevity

Model: 10-month-old and 22-month-old naturally aged mice / Rats with Partial Discectomy (PDE)-induced Temporomandibular Joint Osteoarthritis (TMJOA).
Dosage: 0.25% αKG and  0.75% αKG
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Longevity Compound Thwarts Age-Related Joint Degeneration: New Study Reveals

Researchers found that alpha-ketoglutarate (αKG) can treat osteoarthritis by preserving cartilage and reducing joint inflammation. 

Search Result: Microglia

Mitochondria-Made Molecule Reverses Memory Loss with Advanced Age

New Harvard Study: Microbiome Depletion Rejuvenates the Aging Brain

NAD+ Supplement Improves Memory & Brain Immune Cells, New Study Reveals

One-Time Anti-Aging Gene Therapy Treatment Prolongs Life by 20%, New Study Shows

Longevity Compound Thwarts Age-Related Joint Degeneration: New Study Reveals