Aside from diet and exercise, senolytics — compounds that remove age-promoting cells — may rejuvenate the immune system and reduce the risk of neurodegeneration and dementia. 

Brain &amp; Neurons

Model: 5xFAD mice
Dosage: 5-µL sprayed into each nostril at concentrations of 30 × 109/100 µL once weekly for two weeks

Exploring a Nasal Spray that Might Delay Alzheimer’s Progression by Years

Researchers use nano-sized vesicles derived from neural stem cells to preserve cognition as well as reduce brain inflammation and plaque buildup in an Alzheimer’s mouse model.

(An aged woman using an intranasal spray to avert Alzheimer's disease progression | NAD.com)

Model: Male Monkeys 
Dosage: 20 mg/kg/day of metformin

Supplementation of metformin — a first-line treatment for type 2 diabetes and the second-most prescribed medication in the U.S. — improves the learning and memory of older monkeys. 

Model: Six to seven-year-old female sheep
Dosage: 100 mg/kg of fisetin on two consecutive days per week for eight weeks by intravenous infusion

Latest Findings: Fisetin Confers Anti-Aging Impact Against Brain Senescence

Researchers find that fisetin cuts inflammation-promoting senescent brain cells and reduces brain injury in aged sheep.

(The image shows the green fluorescence labeled senescence protein p16 and neurons labeled red with their overlapping orange coloration indicating senescent neurons in the cortex)

Explore the cutting-edge research revealing Fisetin's remarkable anti-aging effects on combating brain senescence. Discover the latest findings and their implications at NAD.com.

Unlocking the Power of Fisetin: Latest Findings on Its Anti-Aging Impact Against Brain Senescence | NAD

Model: C57BL/6 mice
Dosage: 400 mg/kg/day injected intraperitoneally for 14 consecutive days

NAD+ Precursor Nicotinamide Enhances Nerve Insulation for Rapid Electrical Signaling

Researchers uncover that nicotinamide stimulates the production of the lipid-rich multilayer membrane — myelin — that allows nerves to rapidly propagate signals in mice.

(A depiction of degenerating myelin, which insulates neurons to rapidly propagate electrical signals in the brain | News-medical.net)

Discover how a Greek study highlights the role of NAD precursor nicotinamide in boosting nerve insulation for faster electrical signal propagation. Explore the implications for nerve health and function.

Search Result: Microglia

Israeli Scientists Proclaim ‘A Healthy Mind Is a Healthy Immune System,’ Revealing How to Slow Brain Aging

Exploring a Nasal Spray that Might Delay Alzheimer’s Progression by Years

Metformin Slows Brain Aging in Older Monkeys, New Research Shows

Latest Findings: Fisetin Confers Anti-Aging Impact Against Brain Senescence

NAD⁺ Precursor Nicotinamide Enhances Nerve Insulation for Rapid Electrical Signal Propagation: Greek Study