The most comprehensive brain model reveals that combining NAD+ (nicotinamide adenine dinucleotide) supplementation with diet and exercise powerfully modulates brain aging. 


<p>Model: C57BL/6N mice<br />
Dosage: 1 g/kg carvedilol in food for one week followed by four weeks of PAGln treatment, consisting of 50 mg/kg per day by injection, and the same PAGln treatment for four weeks followed by 50 mg/kg per day of ABT263 via oral gavage for five days</p>


New Study Suggests Combining Senolytics with Blood Pressure Medication Counteracts an Aging Gut

Carvedilol, a blood pressure medication, and the senolytic agent ABT-263 both attenuate cellular senescence—an age-related, dysfunctional cellular state—driven by a gut bacterial metabolite in mice.

Aging &amp; Longevity

Will Interventions that Delay Aging in Animals Work for Humans?

Researchers have shown that using certain agents targeting hallmarks of aging (like inflammation) can extend lifespan in mice, yet human trials are just beginning to uncover whether they work in humans.

(Aged individuals may benefit from aging interventions that work in animal models | NAD.com)

Scientists find that limiting folate (vitamin B9) beginning at mid-age leads to slowed aging in mice. 

Is reducing vitamin B9 intake good or bad in older age?

With over 246 million data points, obtained from 108 participants, scientists show that we rapidly age around 45 and 60. 

Stanford researchers find that our biological age accelerates during mid-life and retirement age. 

Search Result: Metabolites

Most Comprehensive Study Places NAD+ at Forefront of Countering Brain Aging

Combining Senolytics with Blood Pressure Medication Counteracts Gut Aging and Promotes Longevity, Suggests New Study

Will Interventions that Delay Aging in Animals Work for Humans?

How Not Eating Leafy Greens Can Make You Age Slower

Epic New Stanford Study Reveals Two Critical Phases of Rapid Aging in Our Lifetime