Ranked fourth on the Rejuvenation Olympics leaderboard, 30-year-old Siim Land lists the supplements he takes to stay young. 


Aging &amp; Longevity

NAD+ Supercharges Immune System Recovery in Older Mice

Researchers from the University of California, Berkeley, found that young mice need NAD+ breakdown, while old mice need NAD+ boosting.

Immunity

The most comprehensive brain model reveals that combining NAD+ (nicotinamide adenine dinucleotide) supplementation with diet and exercise powerfully modulates brain aging. 


Model: 10-month-old and 22-month-old naturally aged mice / Rats with Partial Discectomy (PDE)-induced Temporomandibular Joint Osteoarthritis (TMJOA).
Dosage: 0.25% αKG and  0.75% αKG
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Longevity Compound Thwarts Age-Related Joint Degeneration: New Study Reveals

Researchers found that alpha-ketoglutarate (αKG) can treat osteoarthritis by preserving cartilage and reducing joint inflammation. 

Skin &amp; Muscle

Model: C57BL/6N mice 
Dosage: 1 g/kg carvedilol in food for one week followed by four weeks of PAGln treatment, consisting of 50 mg/kg per day by injection, and the same PAGln treatment for four weeks followed by 50 mg/kg per day of ABT263 via oral gavage for five days

New Study Suggests Combining Senolytics with Blood Pressure Medication Counteracts an Aging Gut

Carvedilol, a blood pressure medication, and the senolytic agent ABT-263 both attenuate cellular senescence—an age-related, dysfunctional cellular state—driven by a gut bacterial metabolite in mice.

Search Result: Metabolite

Fourth Slowest Ager in World Siim Land’s 2025 Longevity Supplement Protocol

NAD+ Supercharges Immune System Recovery In Older Mice, Hurts Blood Stem Cells of Young Mice

Most Comprehensive Study Places NAD+ at Forefront of Countering Brain Aging

Longevity Compound Thwarts Age-Related Joint Degeneration: New Study Reveals

Combining Senolytics with Blood Pressure Medication Counteracts Gut Aging and Promotes Longevity, Suggests New Study