Making CAR-T Cells Young Again: Restoring NAD+ to Rejuvenate Immunotherapy in Aging

A combined treatment of NMN with 78c (a small molecule that inhibits an NAD+-degrading enzyme) enhances the effects of the anti-cancer CAR-T cell therapy in aged mice and human cells.

(A CAR-T cell [red] attacking a cancer cell [blue] | Crown Bioscience Blog)

Cancer

Ranked fourth on the Rejuvenation Olympics leaderboard, 30-year-old Siim Land lists the supplements he takes to stay young. 


Aging &amp; Longevity

NAD+ Supercharges Immune System Recovery in Older Mice

Researchers from the University of California, Berkeley, found that young mice need NAD+ breakdown, while old mice need NAD+ boosting.

Immunity

The most comprehensive brain model reveals that combining NAD+ (nicotinamide adenine dinucleotide) supplementation with diet and exercise powerfully modulates brain aging. 


Model: 10-month-old and 22-month-old naturally aged mice / Rats with Partial Discectomy (PDE)-induced Temporomandibular Joint Osteoarthritis (TMJOA).
Dosage: 0.25% αKG and  0.75% αKG
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Longevity Compound Thwarts Age-Related Joint Degeneration: New Study Reveals

Researchers found that alpha-ketoglutarate (αKG) can treat osteoarthritis by preserving cartilage and reducing joint inflammation. 

Search Result: Metabolite

Making CAR-T Cells Young Again: Restoring NAD+ to Rejuvenate Immunotherapy in Aging

Fourth Slowest Ager in World Siim Land’s 2025 Longevity Supplement Protocol

NAD+ Supercharges Immune System Recovery In Older Mice, Hurts Blood Stem Cells of Young Mice

Most Comprehensive Study Places NAD+ at Forefront of Countering Brain Aging

Longevity Compound Thwarts Age-Related Joint Degeneration: New Study Reveals