Advanced Alzheimer’s Can Be Reversed With NAD+ Restoration, Study Shows in Mice

Researchers at Case Western Reserve University have shown that late-stage neurodegeneration may be biologically reversible, at least in the right conditions, in mice.

(Case Western Reserve University | Cleveland 19)

Brain &amp; Neurons

Mitochondria-Made Molecule Reverses Memory Loss with Advanced Age

A naturally occurring compound, α-lipoic acid, helped elderly mice think like younger mice by restoring energy balance and calming brain inflammation, according to Second Hospital of Hebei Medical University researchers.

(Alpha-lipoic acid’s molecular structure | Sasha’s of Saratoga)

Participants: Older adults with elevated HbA1c
Dosage: Nicotinamide (250 mg), palmitoylethanolamide (600 mg), oleoylethanolamide (400 mg), and spermidine (8 mg)

In older adults, the combination of nicotinamide, palmitoylethanolamide (PEA), oleoylethanolamide (OEA), and spermidine counters cardiovascular and metabolic aging. 

Study conducted by People Science Inc. (image: prnewswire.com)

Clinical Trials

Andrew Huberman’s Updated Supplement Stack for 2026

Stanford neuroscientist Andrew Huberman’s updated supplement list includes the NAD+ precursor NMN, along with other compounds for sleep and cognitive performance.

Dr. Andrew Huberman’s new supplement stack for 2026 includes NMN, along with supplements supporting sleep, testosterone synthesis, and cognitive function.

Aging &amp; Longevity

Model: 14- to 15-month-old male C57BL/6J mice
Dosage: 50 mg injection of 3′-deoxyadenosine (cordycepin) because it was shown not to be absorbed if administered orally

In mice, cordycepin—a molecule found in cordyceps mushrooms—prolongs lifespan and improves memory, strength, cardiac function, hormone levels, and metabolism. 


Cordyceps mushrooms (image: antioxi-supplements.com). 

Search Result: Metabolism

Advanced Alzheimer’s Can Be Reversed With NAD+ Restoration, Study Shows in Mice

Mitochondria-Made Molecule Reverses Memory Loss with Advanced Age

Supplement Combo that Mimics Fasting Counters Aging, New Study Shows

Andrew Huberman’s Updated Supplement Stack for 2026

Cordyceps Mushroom Molecule Prolongs Lifespan If Taken At Correct Time of Day, New Study Shows