Implanting DNA “rivers” into older mice significantly extends their lifespan and reduces age-promoting senescent cells in multiple vital organs. 

Professor of Molecular Immunology at Oxford University, and one of the researchers on the study, Dr. Michael Dustin (image: kennedy.ox.ac.uk). 

DNA Repair

Model: Male COX7RP transgenic mice with systemic overexpression of COX7RP, aged under standard laboratory conditions and compared with age-matched wild-type controls.
Dosage: Not applicable. COX7RP activity was increased via genetic overexpression rather than drug administration.

Boosting mitochondrial efficiency by increasing COX7RP activity extended lifespan in mice while improving energy production and reducing inflammation.

Aging &amp; Longevity

University of California (UC) Berkeley scientists moderately extend the lifespan of old mice by giving them oxytocin (sometimes called the "love hormone") and a compound that inhibits inflammation.  

Model: UM-HET3 Mice 
Dosage: 0, 75, 150, 300, 600, and 1200 ng epicatechin/mg food; 0, 0.075, 0.15, 0.3, 0.6, and 1.2 ng halofuginone/mg food; and 0, 37.5, 75, 150, 300, and 600 ng mitoglitazone/mg food, all given ad libitum in food starting at seven months old

Three Compounds Show Promise for Male Longevity

Data from a rigorous longevity study show promise for three new compounds, adding to the repertoire of mouse lifespan-extending substances.

(The three compounds’ effects on median lifespan extension | Rapamycin Longevity News)

The world’s most rigorous longevity study presents data showing promise for three new lifespan-extending compounds in male mice.

Model: Male C57BL/6 mice 
Dosage: 10 mg/kg of glyburide via intragastric injections or 500 mg/kg of NMN by oral water supply daily starting at 12 months of age until death

Common Diabetes Medication Might Extend Life, Suggests New Study

Researchers show that glyburide, an anti-diabetes drug, extends lifespan and reduces frailty in naturally aged mice.

(The chemical structure of glyburide, a diabetes medication | PubChem)

Search Result: Median Lifespan Extension

Newly Discovered DNA “Rivers” More Than Double Lifespan: Oxford University

New Study Shows Increasing Mitochondrial Protein Improves Energy Production and Extends Lifespan

New UC Berkeley Study: “Love Hormone” and Anti-Inflammatory Combo Extend Life

Three Compounds Show Promise for Male Longevity

Common Diabetes Medication Might Extend Life, Suggests New Study