University of Southern California (USC) scientists help to uncover why human intelligence declines with age, pointing to a newly discovered cellular target.


The principal investigator on the study, Dr. Michael Bonaguidi (image: usc.edu).

Brain &amp; Neurons

A new U.S. Army study shows that waist circumference and belly fat are far stronger determinants of circulating testosterone levels than aging.


An image from a previous publication authored by Dr. Karl E. Friedl, one of the U.S. Army scientists on the current study. 

Aging &amp; Longevity

Model: Eight-week-old C57BL/6J mice treated with 300 mg/kg/day of D-galactose by subcutaneous injections for eight weeks
Dosage: 100 mg/kg/day of NMN in drinking water for eight weeks and 5 × 10 5 hUC-MSCs suspended in 150 µL of PBS via tail vein injection on the first day of weeks five through seven

NMN Enhances Stem Cell Therapy’s Effects on Immune Aging in Latest Study

Combining NMN with umbilical cord–derived stem cells improved motor and cognitive function while reducing markers of immune aging in mice with chemically induced aging.

(An image of human umbilical cord-derived mesenchymal stem cells under a microscope | NAD.com)

NMN with a stem cell therapy reduced markers of immune aging and improved coordination and memory performance in mice with chemically induced aging-like changes.

Immunity

Model: Apoe−/− C57BL/6J mice fed a high-fat diet
Dosage: 1 × 109 CFU per 0.1 mL of Bacteroides uniformis administered to mice via oral gavage for 12 weeks and 25 mg/kg of pentadecanoic acid via oral gavage three times per week for eight weeks

New Study: Gut Bacteria Metabolite Reduces Arterial Plaque Burden by 50%

Researchers identified pentadecanoic acid, a gut-bacteria-produced metabolite, that lowered LDL cholesterol and limited arterial plaque buildup in mice.

(A depiction of various gut bacteria in the intestines | NAD.com)

A gut bacterial metabolite reduced arterial plaque buildup by about 50% in mice, revealing a potential link between gut microbes and cholesterol regulation.

Cardiovascular

A new scientific review questions how much researchers actually know about fasting’s ability to enhance cellular recycling—particularly in humans.

The spherical structure depicts an autophagolysosome. 

Search Result: MIT

Beyond Neurons: New Study Pinpoints Immature Brain Cells Behind Age-Related Drops in Intelligence

Why Low Testosterone Isn’t Just About Getting Older: New U.S. Army Findings Point to Belly Fat

NMN Enhances Stem Cell Therapy’s Effects on Immune Aging in Latest Study

New Study: Gut Bacteria Metabolite Reduces Arterial Plaque Burden by 50%

Does Fasting Really Trigger Autophagy? New Study Challenges Popular Longevity Belief