Advanced Alzheimer’s Can Be Reversed With NAD+ Restoration, Study Shows in Mice

Researchers at Case Western Reserve University have shown that late-stage neurodegeneration may be biologically reversible, at least in the right conditions, in mice.

(Case Western Reserve University | Cleveland 19)

Brain &amp; Neurons

Mitochondria-Made Molecule Reverses Memory Loss with Advanced Age

A naturally occurring compound, α-lipoic acid, helped elderly mice think like younger mice by restoring energy balance and calming brain inflammation, according to Second Hospital of Hebei Medical University researchers.

(Alpha-lipoic acid’s molecular structure | Sasha’s of Saratoga)

Andrew Huberman’s Updated Supplement Stack for 2026

Stanford neuroscientist Andrew Huberman’s updated supplement list includes the NAD+ precursor NMN, along with other compounds for sleep and cognitive performance.

Dr. Andrew Huberman’s new supplement stack for 2026 includes NMN, along with supplements supporting sleep, testosterone synthesis, and cognitive function.

Aging &amp; Longevity

Harvard: Microbiome Depletion Rejuvenates the Aging Brain

Harvard researchers find that aged mice lacking gut bacteria exhibit a brain more like that of young mice. 

The Principal Investigator of the study, Dr. Lee Rubin (image: harvard.edu). 

<p>Model: 11-month-old male C57BL/6J mice </p>
<p>Dosage: 30 mg/kg/day of NTX-748 (based on a small molecule called 78c) for 4 months, administered orally</p>


Blocking NAD+ Breakdown Improves Cognitive and Physical Performance

Buck Institute scientists find that blocking the CD38 enzyme, which elevates NAD+ (nicotinamide adenine dinucleotide), counteracts age-related cognitive and physical decline in mice.  

Study conducted at the Buck Institute for Research on Aging (image: linkedin.com).

Search Result: Learning and memory

Advanced Alzheimer’s Can Be Reversed With NAD+ Restoration, Study Shows in Mice

Mitochondria-Made Molecule Reverses Memory Loss with Advanced Age

Andrew Huberman’s Updated Supplement Stack for 2026

New Harvard Study: Microbiome Depletion Rejuvenates the Aging Brain

Blocking NAD+ Breakdown Improves Cognitive and Physical Performance: New Study