In the largest study of its kind, Viennese scientists analyzed over 25, 000 human tissue slices with AI to determine the architectural changes that occur with aging and how to predict disease. 


Aging &amp; Longevity

By examining chemical tags on DNA that modulate our genes, scientists have discovered which genes are most affected by aging across more than a dozen human tissues.

The study was led by Dr. Nir Eynon from the Australian Regenerative Medicine Institute (image: vu.edu.au). 

Epigenetics

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<p class="PDq2pG_selectionAnchorContainer" data-start="0" data-end="125">Model: 4-week-old <span class="hover:entity-accent entity-underline inline cursor-pointer align-baseline"><span class="whitespace-normal">SM/J</span></span> mice (with <span class="hover:entity-accent entity-underline inline cursor-pointer align-baseline"><span class="whitespace-normal">C57BL/6J</span></span> comparison mice)</p>
<p data-start="127" data-end="279" data-is-last-node="" data-is-only-node="">Dosage: Weekly intraperitoneal injections of 40 mg/kg Navitoclax or 5 mg/kg Dasatinib + 50 mg/kg Quercetin from 4 to 6–8 or 17 weeks of age.</p>
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Dasatinib and Quercetin Delay Early-Onset Disc Degeneration in Mice

Researchers find that clearing senescent cells preserves disc structure and slows early-onset disc degeneration in mice.


<p><span style="font-weight: 400;">Model: 5xFAD mouse model for Alzheimer’s disease </span></p>
<p><span style="font-weight: 400;">Dosage: Oral administration of 457 mg/kg/day of glucosamine for 2 weeks </span></p>


Supplementing with glucosamine, a compound found in our cartilage, increases the risk of mortality from dementia in certain individuals while also worsening memory in mice that model dementia. 

Study led by Dr. Ramon Sun on the far right (image: mbi.ufl.edu). 

Brain &amp; Neurons

Cellular reprogramming, an innovative age-reversal technology, stimulates the regeneration of heart cells after a heart attack in mice. 

Search Result: Green Tea

Researchers Pull the Strings of Artificial Intelligence to Measure Aging: New Study

Scientists Find a Gene That Is Altered Across All Tissues Tested

Dasatinib and Quercetin Delay Early-Onset Disc Degeneration in Mice

Common Joint Health Supplement May Progress Dementia, New Study Finds

New Age-Reversing Tech Helps Heart Regenerate, Scientists Find