Could Aging Leave a "Memory" That Spreads and Even Passes to the Next Generation?

A new aging model posits that aging imprints signatures across molecular, tissue, and organ system levels, and these signatures may also transmit across generations.

(A new theory posits that imprinted cellular signatures of aging can transmit between generations | NAD.com)

A new theory posits that aging imprints molecular-, cellular-, tissue-, and organ system-level signatures that may transmit across generations.

Aging &amp; Longevity

Dark Chocolate Compound Linked to Slower Aging, Study Finds

Elevated circulating theobromine—derived from cocoa—was associated with a slower pace of aging, according to two assessments.

(The molecular structure of theobromine | Forbes)

A compound derived from dark chocolate, theobromine, circulating at higher levels, is associated with a reduced pace of aging.

Epigenetics

Model: Cybrids composed of Rho0 cells with human platelet mitochondrial DNA from participants between 7 days old and 99 years old 
Dosage: 5 mM of n-Acetyl-L-Cysteine and 3 mM of nicotinamide riboside, with medium changed every three days until the cell population reached between 1 and 10 million

New Study: Combining NR with NAC May Slow Telomere Shortening

New research suggests that nicotinamide riboside (NR) combined with N-acetyl cysteine (NAC) prevents telomere shortening linked to genetic sequences within the cell’s powerhouse (mitochondria) in human cells.

(Telomeres [highlighted in gold] at the ends of a chromosome | NAD.com)

A new study suggests the NAD+ precursor NR combined with the antioxidant NAC may counteract telomere shortening, a hallmark of aging.

Model: Ten-month-old male EFAD mice 
Dosage: 14.4 ppm of alfatradiol in diet for five months

USC Study: Longevity-Promoting Drug Counteracts a Genetic Predisposition to Alzheimer's

The drug alfatradiol, also known as 17ɑ-estradiol, reduces cognitive errors on a test of memory and lowers neuronal plaques in mice genetically predisposed to Alzheimer’s disease.

(The University of Southern California | College Matchpoint)

Researchers unveil data suggesting the drug alfatradiol improves signs of frailty, reduces cognitive errors, and reduces neuronal plaques in mice with a genetic predisposition to Alzheimer’s disease.

Brain &amp; Neurons

Cornell and UPenn scientists find that mice introduced to the wild as infants age faster than lab mice, but what does this mean for humans?


Search Result: Genetics

Could Aging Leave a “Memory” That Spreads and Even Passes to the Next Generation?

Dark Chocolate Compound Linked to Slower Aging, Study Finds

New Study: Combining NR with NAC May Slow Telomere Shortening

USC Study Suggests Longevity-Promoting Drug Counteracts a Genetic Predisposition to Alzheimer’s

Do Humans Age Like Mice? New Study Reveals Surprising Similarities