Model: Young (2- to 4-month-old) and aged (9- to 10-month-old) C57Bl/6JR mice, APP/PS1 mice, and 5xFAD mice 
Dosage: 0.2 mg/mL of doxycycline in drinking water starting at least 7 days before surgery and ceased 2 days before the partial cellular reprogramming window for engram tagging, after which it was immediately reintroduced

Gene Therapy Restores Cognitive Function in Aging and Alzheimer’s Disease

Delivering a gene therapy targeting ensembles of neurons that store memories restores learning and memory capabilities in mouse models of aging and Alzheimer’s disease.

(The study’s principal investigator, Professor Johannes Gräff | 24 Heures)

A partial cellular reprogramming gene therapy targeting memory trace cells restores facets of learning and memory in aged mice and those modeling Alzheimer’s disease.

Brain &amp; Neurons

Approved Human Study Sets Up Pivotal Test for Aging Theory from Harvard’s David Sinclair

In a major proving ground test for the longevity field, the FDA has given its approval for a human trial for a gene therapy attempting a near-total rejuvenating reset of cells.

(David Sinclair, Michael Ringel, Sharon Rosenzweig-Lipson, and Jerry McLaughlin of Life Biosciences | Longevity.technology)

The FDA has greenlighted Life Biosciences’ first human trial testing whether their gene therapy can confer a near-total rejuvenating reset of cells.

Clinical Trials

Based on current scientific evidence, Dutch researchers have ranked existing anti-aging interventions based on how likely they are to protect against DNA damage and aging. 


On the far right, one of the researchers, Dr. Jan H.J. Hoeijmakers (image: amazinggerasmusmc.nl). 

DNA Repair

Elon Musk Says Figuring Out How to Reverse Aging ‘Highly Likely’

The business magnate and SpaceX CEO, Elon Musk, now believes that death is a kind of engineering bug that determined aging scientists can eventually fix.

The high-profile American entrepreneur, Elon Musk, now says figuring out human lifespan extension is highly likely.

Aging &amp; Longevity

Model: Female New Zealand white rabbits 
Dosage: 20 mg/kg of fisetin

Fisetin reduces susceptibility to a heart condition called atrial fibrillation (AF) and eliminates age-promoting senescent cells in aged rabbits.  

On the right is Principal Investigator Gideon Koren, MD (image: brownhealth.org).

Search Result: Genes

Gene Therapy Targeting Memory-Encoding Neurons Restores Cognitive Function in Aging and Alzheimer’s Disease

FDA Greenlights Life Biosciences’ Human Study, Setting Up Pivotal Test for Aging Theory from Harvard’s David Sinclair

NAD+ Ranked #2 Most Powerful Way to Reverse DNA Damage & Aging

Elon Musk Says Figuring Out How to Reverse Aging ‘Highly Likely’

Natural Compound Fisetin Combats Heart Disease by Eliminating Senescent Cells: New Brown University Study